DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and abcc5

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_001182542.1	Gene:	abcc5 / 336147	ZFINID:	ZDB-GENE-050517-17	Length:	1426	Species:	Danio rerio

Alignment Length:	1398	Identity:	454/1398 - (32%)
Similarity:	729/1398 - (52%)	Gaps:	171/1398 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ADELPENPRERS---------SPLSSL-----------MFCF-------ALPVLFKGRKKTLEQK 43
            |.||.|:...||         .|:.|.           :|.|       :|.|| ..:|..|..:
Zfish    63 AKELEEDAAGRSKYHHSVCVLKPIRSTSKYQHPVDNAGLFSFMTFNWLTSLAVL-AHKKGQLFLE 126

  Fly    44 DLYRALKEHKSDSLG-DRLCAAWDEQV-AKNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVT 106
            |:: |:.:.:|..:. .||...|:|:: ::.....|.|.:.......|.::.:.|:..: |...:
Zfish   127 DIW-AVSQFESCEINRRRLAGLWEEEIRSRGNDASLRRVVWHFCRTRLLLSILCLMVTQ-LAGFS 189

  Fly   107 QPICLI-GVMAYFAGNDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLGL-LHLGMKMRIALSSLIY 169
            .|..:: .::.|...::||.....|...||:|..:.. ...|.....| ...|.::|.|:.::.:
Zfish   190 SPAFVVWRLLEYTQRSEPDLPYGLLLVLGLLATELIR-SWSHALTWALNYRTGTRLRGAILTMAF 253

  Fly   170 RKALRLSRTALGDTTVGQVVNLLSNDVGR-FDLVLINVHYLWIAPLELIAVTYLMY--LEIGISS 231
            .|.|||  .:|.:.::|:::|:.|.|..| |:...:.   ..:|...|:||..:.|  ..:|.:|
Zfish   254 HKILRL--RSLREKSMGELINMCSGDGQRMFEAAAVG---SLLAGGPLVAVLGMAYNLFVLGPTS 313

  Fly   232 MFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMT 296
            :.|.|:.:||.|...:..:.|:..|.:....||:||:.||||::.|:.||||||.|.|.:.|...
Zfish   314 LLGSAVFILFYPTMMFSSRLTAYFRRKGVAVTDQRVQKMNEILNYIKFIKMYAWVKAFSQAVRRI 378

  Fly   297 RFNEMLCIKQVNYIRGILISFAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTM 361
            |..|...:::..|.:.|.:..|..:..|.:.::....:|||..|.|.:||.|...:|.:..::.:
Zfish   379 RDEERQILERTGYFQSITVGVAPIVVVIASVATFSTHMLLGYDLTAAQAFTVVTVFNAMTFALKV 443

  Fly   362 FFPQGISEFAELLVSVRRLEAFMHRPETKV-----RDKS---KVKNANQKAE--------SPNG- 409
             .|..:...:|..|::.|.::.:...|.|:     |:.|   ::..|:...|        ||.|
Zfish   444 -TPFSVKSLSEASVAIDRFKSLLLMAEVKMIRELPRNPSVAVEMSGASLAWETGGHSAQPSPRGT 507

  Fly   410 ---------------DSPKGNGIPEN------LIEFSQFQARWE----------SHSLEPTLEDI 443
                           |.||.:.|.|.      |.:.|...|...          |..|:.||..|
Zfish   508 PHVGTRGCRKKRRQRDVPKHHAILEEETHGQLLNDVSGEMASSPKDQTLHVPTISQRLQRTLHCI 572

  Fly   444 NLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFG 508
            :|.:.:.|||.|.|.||:||:|||.||||::....||:.::|.::|.||:.|:...:.|.|||||
Zfish   573 DLSIQKGKLVGVCGSVGSGKTSLISAILGQMTLLEGTVAVDGDFAYVAQQAWILNASFRDNILFG 637

  Fly   509 LDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDP 573
            .:.::.||:.::..|.|..|..:||.||.|.:|||||:|||||:.|||||||:|....||:||||
Zfish   638 KEMEEERYQAILSACCLRPDLAMLPSGDLTEIGERGANLSGGQRQRISLARALYSNRGIYILDDP 702

  Fly   574 LSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLD 638
            |||:|.|||.|:|:..::..||.:.||.||||||:|...|.:::|..|.|:..|::..:.....|
Zfish   703 LSALDAHVGNHIFNNAIKKQLRGKTVIFVTHQLQYLVDCDDVIVMRDGSIAEQGSHEDLMNVNGD 767

  Fly   639 FA------QLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAE 697
            :|      ||...|                   ::.||: .:.||...||..:        |.|.
Zfish   768 YAAMFNNLQLGETP-------------------IIEVPN-KKSGSSLKKPLEK--------SKAG 804

  Fly   698 SMAQEAS-------LQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFL 755
            |:.:|.|       |...|.|.:|.:...:||.|:.:...|.:..|::.|.:......:.::::|
Zfish   805 SVKKEKSTTQGDGQLMQVEERGKGSVPWAVYKVYIQALGGWPVFLFILALFILNVGSTAFSNWWL 869

  Fly   756 SYWVDKNVDGQTDINT-----------DPQDMYYFAALNV----AVVVFTIVRTMLFYKMAMRSS 805
            .||: |...|.|.:..           |...|.::||:..    .:::..::|.::|.|..:|:|
Zfish   870 CYWI-KQGSGNTTVQVGNSSVLSESMRDNPLMQHYAAVYTMSMGVMLLLKLLRGIVFVKGTLRAS 933

  Fly   806 TQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICI 870
            ::||:.::|.|.|:.|.||:|.|:.|||||||||:.::|..||.......|..:.:|..:.||..
Zfish   934 SRLHDELFQKILRSPMKFFDTTPTARILNRFSKDMDEVDTRLPFQAEMFTQNVILVLFCLAVIGS 998

  Fly   871 TNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELI 935
            ..|::|:....|.::|..:........|::|||:.|.:||..||::::|.||.|:.|.|.:.|.:
Zfish   999 VFPWFLVAVGPLVLLFTVLHVVSRVFIRELKRLDNVTQSPFLSHIASSIQGLTTVHAYGKEDEFL 1063

  Fly   936 AEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQ-SPGEVGLAITQAMGM 999
            ..:..|.|.:.:.:|.|....|.....||......|.|..|...:...| .|...||||:.|:.:
Zfish  1064 HRYQELLDQNQAPFYLFSCAMRWLAVRLDVISVALISITALMIVLMHGQIPPAYAGLAISYAVQL 1128

  Fly  1000 TGMVQWAMRQSAELENTMTAVERVVEYDE---IEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLR 1061
            ||:.|:.:|.::|.|...|:|||:..|.:   :|.....   :.|.|...||::|||:
Zfish  1129 TGLFQFTVRLASETEARFTSVERIHHYIKSLSLEAPARV---KNKAPPSDWPQEGEIV------- 1183

  Fly  1062 YFPDPQAKY------VLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDT 1119
             |...:.||      :||..:|.:||.||:|||||||:|||||...|:|| ....|.|.||..:.
Zfish  1184 -FDQTEMKYRDNLPLILKKASFTVRPKEKIGIVGRTGSGKSSLGVVLYRLVEPCGGSIKIDGVNI 1247

  Fly  1120 ADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKI 1184
            .|:||.|:|||:||||||||||||::|.|||||.:|::|::|||||...:|..:|:||..|:|::
Zfish  1248 CDIGLADVRSKLSIIPQEPVLFSGTVRSNLDPFSQYSEAQIWDALERTHMKECVSQLPLKLESEV 1312

  Fly  1185 SEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRL 1249
            .|.|.|||||:|||:|:||.:||:.::|::|||||.:..:||.|||.|||:.|:|||.||||||:
Zfish  1313 VENGENFSVGERQLLCVARVLLRQCKILILDEATAAMGTETDCLIQETIRNAFQDCTTLTIAHRV 1377

  Fly  1250 NTIMDSDRVLVMDAGHLVEFGSPYELLTSSESK 1282
            :|::..||::|::.|.:|||..|.:||.:..|:
Zfish  1378 HTVLSCDRIMVLNQGQVVEFDEPSKLLANENSR 1410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	448/1385 (32%)
		ABC_membrane	93..359	CDD:294371	73/270 (27%)
		ABCC_MRP_domain1	422..622	CDD:213217	93/209 (44%)
		ABC_membrane	735..978	CDD:294371	73/257 (28%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	117/227 (52%)
abcc5	NP_001182542.1	intraplasmic N-terminal	1..59
		transmembrane domain 1	59..149		20/87 (23%)
		CFTR_protein	95..1419	CDD:273530	446/1366 (33%)
		ABC_membrane	177..441	CDD:294371	73/270 (27%)
		nucleotide binding domain 1	188..248		12/60 (20%)
		transmembrane domain 2	279..379		34/102 (33%)
		nucleotide binding domain 2	403..450		11/47 (23%)
		ABCC_MRP_domain1	552..751	CDD:213217	91/198 (46%)
		ABC_membrane	851..1132	CDD:294371	81/281 (29%)
		ABCC_MRP_domain2	1180..1400	CDD:213211	117/227 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585983
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.660