DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mrp4 and abcc3

DIOPT Version :9

Sequence 1:NP_650086.2 Gene:Mrp4 / 41387 FlyBaseID:FBgn0263316 Length:1316 Species:Drosophila melanogaster
Sequence 2:XP_009304645.1 Gene:abcc3 / 323301 ZFINID:ZDB-GENE-050517-16 Length:1540 Species:Danio rerio


Alignment Length:1390 Identity:487/1390 - (35%)
Similarity:743/1390 - (53%) Gaps:165/1390 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAK------ 71
            |...:..||.:.|.:...:..||.|..||.|||:...|...|:.:...|...|:.:.:|      
Zfish   204 PETTAGFLSRMTFWWFTRMAIKGYKSPLENKDLWSLNKNDSSELVVPGLLNQWEVEKSKAHSSDD 268

  Fly    72 ---------------------NETPRLGR-----------------ALTKVFGFHLFITGVFLLA 98
                                 ||:|....                 ||.:.||.:..|...|.|.
Zfish   269 QNVKEQVTFTKPGSGAESNHVNESPEEAEVLLSKQQQKSRQPSFLWALLRAFGPYFLIGSAFKLL 333

  Fly    99 QEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIA 163
            |:.:|.: .|..|..::|:...:|.........|..:...|:....|.|.:.......||::|..
Zfish   334 QDLITFI-NPQLLRMLIAFTKQSDVPSWWGYALAFLMFGTSLLQTLILHQHFQYCFVTGMRLRTG 397

  Fly   164 LSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIG 228
            :...||||||.::..|...:|||:||||:|.|..||..:...::.||.|||::....:.::..:|
Zfish   398 IIGAIYRKALVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAPLQIFLALFFLWQNLG 462

  Fly   229 ISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVV 293
            .|.:.|||:|:|.:||.:::..:|...::......|:|:::||||::||:|:|:||||..|...:
Zfish   463 PSVLAGVAVMVLLIPFNAFIAMKTRTYQVEQMKYKDDRIKLMNEILNGIKVLKLYAWEPSFRDKI 527

  Fly   294 EMTRFNEMLCIKQVNYIRGI-------------LISFAMFLSRIFTSSSLIAFVLLGNILNAEKA 345
            ...|..|:..:::..|:..:             |.|||:|::           |...|:|:||||
Zfish   528 LQIRQKELHVLRKTAYLSALSTMAWTSAPFLVALTSFAVFVN-----------VDEKNVLDAEKA 581

  Fly   346 FFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAES-PNG 409
            |...:.:||||..:.| .||.||...:..||::||:.|::..|.......:..|..:.|.| .||
Zfish   582 FVSLSLFNILRFPLNM-LPQVISSIVQASVSLKRLQDFLNHDELDPESVDRKSNTTEYAVSVVNG 645

  Fly   410 DSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGEL 474
                         :||     |.... :..|::||:.:.:..|:||:|.||.||:|||.|:|||:
Zfish   646 -------------KFS-----WAKRD-QVILDNINVLVPQGSLLAVVGHVGCGKTSLISALLGEM 691

  Fly   475 PGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTI 539
            ....|.:.|.||.:|..|:.|:...|:|.|||||..:.:.:||.|::.|||..|.|:||.||.|.
Zfish   692 EKLDGQISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTE 756

  Fly   540 VGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSELVILV 602
            :||:|.:|||||:.|:|||||:|..||:|||||||||||.||.:|:||..:  .|.|:.:..|||
Zfish   757 IGEKGINLSGGQRQRVSLARALYSEADVYLLDDPLSAVDAHVAKHIFDHVIGPEGALKGKTRILV 821

  Fly   603 THQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDL---DEI-------- 656
            ||.:.||.|.:.|:::..||:|.||:|..:.|....||:.|.  |...||:   ||:        
Zfish   822 THGISFLPQVNNILVLVDGRVSEMGSYQDLLRQNGAFAEFLR--NYSLEDIIEDDELTVSFDEEE 884

  Fly   657 ----DGAGGDGLDLL-NVP-------------SLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEA 703
                :.|..:..|:: |.|             |:.....:|.|..:|..      ..:|....|.
Zfish   885 EEFPEDALSNHTDMVDNEPVVNEARRQFMRQMSIMSNDVENPKKMSRRR------RCSERKHPET 943

  Fly   704 SLQMQETRVE----------GKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYW 758
            ..:.:|.:||          |::.|.:|.||:.:... .:..|:.||..........|:::||.|
Zfish   944 PTEKKEPKVEKLIQAETTETGRVKLQVYWEYVKAIGP-LLALFICFLYGCQSAAAIGANFWLSEW 1007

  Fly   759 VDKNVDGQTDINTDPQDMY-----YFAALNVA--VVVFTIVRTMLFYKMAMRSSTQLHNAMYQGI 816
            .:..:..:|      |:|.     .:|||.::  |::.:|......|. .:|::...|..|...:
Zfish  1008 TNDALHNRT------QEMLQTRVGVYAALGISQGVLILSICLLCRAYS-TLRAARHTHQHMLNSV 1065

  Fly   817 TRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDV-VQLFLTLLGIIVVICITNPYYLILTL 880
            .||...||...||||:|||||||:..:|.::|. .:|: ::.|...:.:::|..:..|.:||:.:
Zfish  1066 LRAPQAFFEATPSGRVLNRFSKDVDTIDSLIPD-NIDIWMRTFWYTVNVLMVCSVLTPIFLIVIV 1129

  Fly   881 ALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLH 945
            .|.:.:::::.||:.|||.:||||:|:|||||||.|.:|||...|||.|.....:...||..|.:
Zfish  1130 PLMLFYWWVQRFYVATSRQLKRLESVSRSPIYSHFSESITGTSVIRAYGRNAAFVLMSDNKVDEN 1194

  Fly   946 SSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQ--SPGEVGLAITQAMGMTGMVQWAMR 1008
            ...||..:.:||..|..:: |....||:....:.:....  |||.|||:::.|:.:|..:.|.:|
Zfish  1195 QKSYYPGIVSNRWLGVRIE-FIGNCIVLFAALFAVTGKDKLSPGLVGLSVSYALQVTMSLNWMVR 1258

  Fly  1009 QSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLK 1073
            .:::||:.:.|||||.||.|.:.|..::..| |||.|.||..|.:...|..:||  ......|||
Zfish  1259 MTSDLESNIVAVERVKEYSETQTEAPWEVLE-KKPPPDWPPLGNVEFVDYSVRY--REGLDLVLK 1320

  Fly  1074 ALNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQE 1137
            .::.::|..||:||||||||||||:...||| |....|.|.||:...:::||.|||||::|||||
Zfish  1321 NISLKVRGGEKIGIVGRTGAGKSSMTLCLFRLLEAAAGEIVIDDVKISEIGLHDLRSKLTIIPQE 1385

  Fly  1138 PVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLA 1202
            ||||||::|.||||||.|:|.::|.|||...|:..::.....|:.:.||||.|.|||||||||||
Zfish  1386 PVLFSGTLRMNLDPFERYSDEEVWKALELSHLQKFVTNQAAKLELECSEGGENLSVGQRQLVCLA 1450

  Fly  1203 RAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLV 1267
            ||:||:.|:||:|||||.||.:||.|||:|||::|:||||.|||||||||||..||||:|.|.:.
Zfish  1451 RALLRKTRILVLDEATAAVDLETDDLIQSTIRTEFQDCTVFTIAHRLNTIMDYTRVLVLDKGQIA 1515

  Fly  1268 EFGSPYELLTSSESKIFHGMVMETG 1292
            ||.:|..|:  ::..:|.||..:.|
Zfish  1516 EFDTPTNLM--NQKGLFFGMAKDAG 1538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mrp4NP_650086.2 CFTR_protein 12..1277 CDD:273530 483/1373 (35%)
ABC_membrane 93..359 CDD:294371 83/278 (30%)
ABCC_MRP_domain1 422..622 CDD:213217 92/201 (46%)
ABC_membrane 735..978 CDD:294371 79/250 (32%)
ABCC_MRP_domain2 1051..1272 CDD:213211 125/221 (57%)
abcc3XP_009304645.1 MRP_assoc_pro 10..1539 CDD:188098 487/1390 (35%)
ABC_membrane 330..595 CDD:279056 83/276 (30%)
ABCC_MRP_domain1 640..841 CDD:213217 95/219 (43%)
ABC_membrane 985..1253 CDD:279056 87/276 (32%)
ABCC_MRP_domain2 1300..1520 CDD:213211 125/221 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586013
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.760

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