DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and Abcc10

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_001101671.1	Gene:	Abcc10 / 316231	RGDID:	1306696	Length:	1494	Species:	Rattus norvegicus

Alignment Length:	1358	Identity:	436/1358 - (32%)
Similarity:	688/1358 - (50%)	Gaps:	153/1358 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PENPRER------SSPLSSLMFCFALPVLFKGRKKTLEQ-KDLYRALKEHKSDSLGDRLCAAWDE 67
            ||: :||      .|.||...:.:..|:|.:|.:..|.| :|..|..:......|.....|.|
  Rat   207 PES-QEREVAEDGESWLSRFSYAWLAPLLARGVRGELRQPQDTCRLPRRLHPAYLARAFQAHW-- 268

  Fly    68 QVAKNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWA 132
                .|..:|.|||...||......|:..:....| ..:.|:.|..::.:........|...|:.
  Rat   269 ----KEGAQLWRALYGAFGCCYIALGLLKMVGTML-GFSGPLLLSLLVGFLEEGQEPLSHGLLYV 328

  Fly   133 AGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVG 197
            .||.:|||.|..:.:.|...:..:.::.|:|:.|::|||.|:|..:.   ...|:|:|||..|..
  Rat   329 LGLASGSVISAVLQNQYGYEVRKVTLQARVAVLSILYRKTLKLGPSR---PPTGEVLNLLGTDSE 390

  Fly   198 RFDLVLIN----VHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLR 258
            |    |:|    .|..|..||:|....||:|.::|::.:.|:.:.||.:|....:..|.......
  Rat   391 R----LLNFAGSFHEAWGLPLQLAITLYLLYEQVGVAFLAGLVLALLLVPVNKVIATRIMANNQE 451

  Fly   259 TALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSR 323
            .....|.||::|.|::|||:|:|.:.||:..|..|:..|..|:..::.:.|:....:.....|..
  Rat   452 MLRHKDARVKLMTELLSGIRVLKFFRWEQALGDRVKACRTQELGRLRVIKYLDAACVYLWAALPV 516

  Fly   324 IFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPE 388
            :......|.:||||:.|.|.|.|...|..::|...:.. ||..|:...|..||:.|::.|:..|
  Rat   517 VICIVIFITYVLLGHQLTATKVFTALALVHMLILPLNN-FPWVINGLLESKVSLDRIQRFLDLP- 579

  Fly   389 TKVRDKSKVKNANQKAESPNG-DSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKL 452
                           :.||.. .||.....|..::|..:....|:...........:||:.:..|
  Rat   580 ---------------SYSPEAYYSPDPPTEPSTVLELHEALFSWDPTGTSQKTFISHLQVKKGML 629

  Fly   453 VAVIGPVGAGKSSLIQAILGELPGESGTLRING---SYSYAAQEPWLFTGTVRQNILFGLDWDKH 514
            |.::|.||.|||||:.||.|||....|.:.::.   .:..|.||||:...|:|.|:|||..:|..
  Rat   630 VGIVGKVGCGKSSLLAAITGELHRLCGWVAVSDLSKGFGLATQEPWIQCATIRDNVLFGKTFDAQ 694

  Fly   515 RYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDT 579
            .||.|::.|||..|..:||.||:|.|||:|.:|||||:|||:||||||:...:|||||||:|||.
  Rat   695 LYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKTLYLLDDPLAAVDA 759

  Fly   580 HVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLT 644
            .|..||..:|:.|.|.....:|.||:.::||:|||:::|:.||:...|..|       :...|:.
  Rat   760 DVANHLLHRCILGVLGHTTRLLCTHRTEYLERADLVLLMEAGRLVRAGPPS-------EILPLVQ 817

  Fly   645 APNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESM--AQEAS--L 705
            |......|.:::..:|                   ..||..|     |....|.:  ||..|  |
  Rat   818 AAPTALADKEQVTDSG-------------------QSPSVHN-----LEKTTEELDVAQNTSGRL 858

  Fly   706 QMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVD-----KNVDG 765
            ..:|::.||.:.|.:|:.|..:..|......::.| |..|...:.||::|::|:.     :|...
  Rat   859 VQEESKSEGAVALHVYRAYWRAMGSGLATAILISL-LLMQATRNGADWWLAHWLSQLKAGRNSSE 922

  Fly   766 QTDINTDPQDMYYFAA----------------------------LNVAVVV------FTIVRTML 796
            :...::.|:.|.:|:.                            |.|...:      .|::|.:|
  Rat   923 ERPASSSPRSMGFFSPRLLLFSPGNLYIPLHKATSNGSSDVHFYLTVYATIAGVNSLCTLLRAVL 987

  Fly   797 FYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTL 861
            |...|::::..||:.:...:..|.:.|:::.||||:|||||.|:..:|:.||.::..::...:.|
  Rat   988 FAAGALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGL 1052

  Fly   862 LGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIR 926
            ||::.|:....|:.|:|...|:.|:|.::..|..:.|:::||.::..||:||||:.|:.|||.:|
  Rat  1053 LGLLAVLGSGLPWLLLLLPPLSFIYYGVQRRYRASFRELRRLGSLTLSPLYSHLADTLAGLPVLR 1117

  Fly   927 ALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLY---IVIIILNYFINPPQ---- 984
            |.||......|...|.:|:....:...||.:    :||....|.   :|..|....:...|
  Rat  1118 AAGATYRFEEENQRLLELNQRCQFASYATMQ----WLDIRLQLMGAAVVSAIAGIALVQHQQGLA 1178

  Fly   985 SPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYD-EI--EPEGEFDSREGKKPSP- 1045
            :||.|||.::.|:.:||::...:....:.|..|.:|||:.||. :|  ||.|:      ...||
  Rat  1179 NPGLVGLVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDIPQEPHGQ------PPQSPH 1237

  Fly  1046 ---SWPEKGEIIAEDLCLRYFPD-PQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFR-L 1105
               ||..:|.:..:|:.|.|.|. |.|   |..:.||:.|.||:|||||||:|||||...||| |
  Rat  1238 QRVSWLTQGSVEFQDVVLVYRPGLPNA---LDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLL 1299

  Fly  1106 SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLK 1170
            ..:.|.:.:|..||:.:.|.:|||::::|||||.||||::|.||||...:.|..||.|||:..|.
  Rat  1300 EPSAGQVLLDGVDTSQLELAELRSQLAVIPQEPFLFSGTVRENLDPQGLHEDRALWQALEQCHLS 1364

  Fly  1171 PLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRS 1235
            .:...: .||..::.|.|.:.|:|||||:|||||:|.:.::|.:|||||:||.:||.|:|.||..
  Rat  1365 EVAMAI-GGLDGELGERGRDLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICR 1428

  Fly  1236 KFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETGQ 1293
            :|.:.||||||||||||::||||||:.||.:||..||..|.....| :|..::..:.|
  Rat  1429 RFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQPHS-LFRQLLQSSQQ 1485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	431/1338 (32%)
		ABC_membrane	93..359	CDD:294371	73/269 (27%)
		ABCC_MRP_domain1	422..622	CDD:213217	87/202 (43%)
		ABC_membrane	735..978	CDD:294371	73/284 (26%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	111/222 (50%)
Abcc10	NP_001101671.1	CFTR_protein	211..1485	CDD:273530	433/1351 (32%)
		ABC_membrane	290..552	CDD:294371	73/269 (27%)
		ABCC_MRP_domain1	599..802	CDD:213217	87/202 (43%)
		ABC_membrane	957..1190	CDD:294371	68/236 (29%)
		PBP2_NikA_DppA_OppA_like	<1201..>1274	CDD:294989	25/81 (31%)
		ABCC_MRP_domain2	1246..1465	CDD:213211	111/222 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345117
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.650