DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mrp4 and Abcc12

DIOPT Version :9

Sequence 1:NP_650086.2 Gene:Mrp4 / 41387 FlyBaseID:FBgn0263316 Length:1316 Species:Drosophila melanogaster
Sequence 2:XP_008770597.1 Gene:Abcc12 / 291923 RGDID:735100 Length:1378 Species:Rattus norvegicus


Alignment Length:1398 Identity:444/1398 - (31%)
Similarity:719/1398 - (51%) Gaps:175/1398 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAK-- 71
            |..||.:.:..||...|.:..||:.:..|.||....|........||....||...|||::.:  
  Rat    41 LAPNPVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDSSDVNAKRLQILWDEEIERVG 105

  Fly    72 NETPRLGRALTK-------------VFGFHLFITGVFLLAQEFLTKVTQ--------PICLIGVM 115
            .|...|||.:.|             :....:...|..:|..:.|..||.        .|||  .:
  Rat   106 PERASLGRVVWKFQRTRVLMDVVANILCIIMAALGPTVLIHQILQHVTNISSGHIGISICL--CL 168

  Fly   116 AYFAGNDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTAL 180
            |.||   .:.:|...||   :|.::            .....:::::|||:||::..  ||...|
  Rat   169 ALFA---TEFTKVLFWA---LAWAI------------NYRTAIRLKVALSTLIFKNL--LSFKTL 213

  Fly   181 GDTTVGQVVNLLSND-VGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPF 244
            ...:.|:|:|:||:| ...|:..|.......|..|.::...|..:: :|.:::.|:.:.|:|:|.
  Rat   214 THISAGEVLNVLSSDSYSLFEAALFCPLPATIPILMVVCAVYAFFI-LGSTALVGICVYLIFIPI 277

  Fly   245 QSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNY 309
            |.::.|..|..|......||:||:.|||.::.|::||||||||.|...:...|..|...:::..|
  Rat   278 QMFMAKLNSAFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEKSFMNTIHDIRKREKKLLEKAGY 342

  Fly   310 IRGILISFAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELL 374
            ::....:.|..:|.|...|:....:.|...|.|..||.|.|.:|:::.|:.: .|..:...||..
  Rat   343 VQSGNSALAPIVSTIAIVSTFTCHIFLKRTLTAPVAFSVIAMFNVMKFSIAI-LPFSVKAVAEAS 406

  Fly   375 VSVRRLE---------AFMHRPE-------------------------TKVRDKSKVKNANQKAE 405
            ||:||::         :::.:||                         .|.:|:.:.....|:||
  Rat   407 VSLRRMKKILVAKSPPSYITQPEDPDTILLLANATLTWEQEINRKRGPLKTQDQRRHVFKKQRAE 471

  Fly   406 --SPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQ 468
              |....|.:|...||.           :|.|.:..|.:|:..:.:.|::.:.|.||:||||||.
  Rat   472 LYSEQSLSDQGVASPER-----------QSGSPKSVLHNISFVVRKGKVLGICGNVGSGKSSLIS 525

  Fly   469 AILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLP 533
            |:||::..:.|.:.::|..:|.:|:.|:|.|.||:|||||..::..||:..|..|.|::|...||
  Rat   526 ALLGQMQLQKGVVAVSGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNSLP 590

  Fly   534 FGDKT-------IVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMR 591
            :||.|       .:||||.:|||||:.|||||||||....:|||||||||||.|||:|:|::|::
  Rat   591 YGDLTECHYPHLQIGERGVNLSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEECIK 655

  Fly   592 GYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRS------------GLDF----- 639
            ..|:.:.|:||||||||||..|.:::::.|.|...||:..:...            ||.|     
  Rat   656 KTLKGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEH 720

  Fly   640 ----AQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMA 700
                |.:.|.....|:..::...|.||..|            :..:|.|  ..|..:.:....:.
  Rat   721 IYNVAMVETLKESQAQRDEDAVLASGDERD------------EGKEPET--EEFVDIKAPVHQLI 771

  Fly   701 QEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAA--DYFLSYWVD--- 760
            |..|.|      ||.:....|..|: ..|..:::.|:| |||...::.|:|  .::|..|:|   
  Rat   772 QIESPQ------EGIVTWKTYHTYI-KASGGYLVSFLV-LCLFFLMMGSSAFSTWWLGLWLDSGS 828

  Fly   761 ------KNVDGQTDINTDPQD----MY---YFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAM 812
                  ::.:...::|...||    ||   |.|:: ::|:.|.|::...|....:.:|:.|||.:
  Rat   829 QVICAPQSNETACNVNQTLQDTKHHMYQLVYIASM-MSVLTFGIIKGFTFTNTTLMASSSLHNRV 892

  Fly   813 YQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLI 877
            :..|..:.|.||:|.|:||::||||||:.:||..||....:.:|.|..::.|:|::..:.|..|:
  Rat   893 FNKIVSSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFSMVVFILVIMAASFPVVLV 957

  Fly   878 LTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQ 942
            :...|||:|:.:...:.:..:::|::|.::|||.:||:::::.||..|.|...:.:.|::|..|.
  Rat   958 VLAGLAILFFILLRIFHRGVQELKQVENISRSPWFSHITSSMQGLGVIHAYDKKDDCISKFKALN 1022

  Fly   943 DLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFIN-PPQSPGEVGLAITQAMGMTGMVQWA 1006
            |.:||....|....|.|...:|....:...::.|...:: ...|....||:::..:.::|::|..
  Rat  1023 DENSSHLLYFNCALRWFALRMDILMNIVTFVVALLVTLSFSSISASSKGLSLSYIIQLSGLLQVC 1087

  Fly  1007 MRQSAELENTMTAVERVVEY-DEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKY 1070
            :|...|.:...|:.|.:.|| ....||.....:.|..|. .||.:|||..:|..:||  ......
  Rat  1088 VRTGTETQAKFTSAELMREYISTCVPEHTQSFKVGTCPK-DWPSRGEITFKDYRMRY--RDNTPL 1149

  Fly  1071 VLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISII 1134
            ||..||..|:..:.||||||||:|||||..||||| ....|.|.|||.|...:||.:||:|:::|
  Rat  1150 VLDGLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICTVGLEELRTKLTMI 1214

  Fly  1135 PQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLV 1199
            ||:||||.|::||||||...:.|..||..||...::..|.:||..||::::|.|.|||||:|||:
  Rat  1215 PQDPVLFVGTVRYNLDPLGSHTDEMLWHVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLL 1279

  Fly  1200 CLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAG 1264
            |:|||:||.::::::|||||::|.:||.|:|:||:..|:.||||||||||||:::.|.||||:.|
  Rat  1280 CMARALLRNSKIILLDEATASMDSKTDTLVQSTIKEAFKSCTVLTIAHRLNTVLNCDLVLVMENG 1344

  Fly  1265 H-----LVEFGSPYELLTSSESKIFHGMVMETG 1292
            .     ::||..|..|....:|.....:..|.|
  Rat  1345 KVQEVLVIEFDKPEVLAEKPDSAFAMLLAAEVG 1377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mrp4NP_650086.2 CFTR_protein 12..1277 CDD:273530 440/1378 (32%)
ABC_membrane 93..359 CDD:294371 75/274 (27%)
ABCC_MRP_domain1 422..622 CDD:213217 90/206 (44%)
ABC_membrane 735..978 CDD:294371 75/260 (29%)
ABCC_MRP_domain2 1051..1272 CDD:213211 113/226 (50%)
Abcc12XP_008770597.1 CFTR_protein 44..1348 CDD:273530 436/1364 (32%)
ABC_membrane 127..388 CDD:294371 75/283 (27%)
ABCC_MRP_domain1 487..686 CDD:213217 91/209 (44%)
ABC_membrane 802..1084 CDD:294371 78/283 (28%)
ABCC_MRP_domain2 1132..1357 CDD:213211 113/226 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345077
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.660

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