DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and Abcc9

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_037172.2	Gene:	Abcc9 / 25560	RGDID:	3787	Length:	1545	Species:	Rattus norvegicus

Alignment Length:	1390	Identity:	432/1390 - (31%)
Similarity:	698/1390 - (50%)	Gaps:	192/1390 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LSSLMFCFALPVLFKGRKKTLEQKDL------------YRALKEHKSDSLGDRLCAAWDEQVAK- 71
            ||...:.:...::....:|.::.|.:            |..|||            |::||..|
  Rat   223 LSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRAVTNYVCLKE------------AYEEQKKKA 275

  Fly    72 ----NETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDR------- 125
                |.||.:..|:.:.||..:.::..|....:.| ....|:|:.|::...  |:|..
  Rat   276 ADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLL-GFAGPLCISGIVQRV--NEPKNNTTRFSE 337

  Fly   126 ---SKAQLWAAGLIAGSVFSVCIGHPYMLG-----LLHLGMKMRIALSSLIYRKALRLSRT--AL 180
               ||..|..|.::|..:|...|.....|.     .:..|:.:|.||.::||.|.||||.:  ::
  Rat   338 TLSSKEFLENAHVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSM 402

  Fly   181 GDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQ 245
            |:.|:||:.||::.:..:....|.....||..|:::|....|:|..:|.|::.|.|:::|..|.|
  Rat   403 GEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQ 467

  Fly   246 SYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYI 310
            .::..:.:..:..|...:.||::..|||:.||:::|:||||..|.|.||.||..|:..:|
  Rat   468 YFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLK----- 527

  Fly   311 RGILISFAMFLS-RIFTSSSL-IAFVLL---------GNILNAEKAFFVTAYYNILRRSVT-MFF 363
                 :||::.| .||.:::: ||.||.         ||.|...:||...:.::||   || :|.
  Rat   528 -----TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHIL---VTPLFL 584

  Fly   364 PQGISEFA-ELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQF 427
            ...:..|| :.::||::|..|:...|.. .|..:........||    ..|..|:....|...|
  Rat   585 LSTVVRFAVKAIISVQKLNEFLLSDEIG-EDSWRTGEGTLPFES----CKKHTGVQSKPINRKQ- 643

  Fly   428 QARW------ESHSLEP----------------------TLEDINLQLGRRKLVAVIGPVGAGKS 464
            ..|:      ::..|.|                      ||.:|::::...:|..::|.||.|||
  Rat   644 PGRYHLDNYEQARRLRPAETEDVAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKS 708

  Fly   465 SLIQAILGELPGESGTLRING-----------------SYSYAAQEPWLFTGTVRQNILFGLDWD 512
            ||:.|||||:....|.:..|.                 |.:||||:|||...||.:||.||..::
  Rat   709 SLLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSSFN 773

  Fly   513 KHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAV 577
            :.||:.|...|:|:.|.:||||||:|.:||||.:|||||:.||.:|||:|:..:|..||||.||:
  Rat   774 RQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSAL 838

  Fly   578 DTHVGRHLFDQCMRGYLRSE--LVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLD-F 639
            |.|:..||..:.:..:|:.:  .|:||||:||:|..||.|:.|..|.:...||...::...:: :
  Rat   839 DIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELY 903

  Fly   640 AQLLTAPNKDAEDLDEIDGAGGDGLDL-LNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEA 703
            ....|..|:..::|::         |: .:..:|.|:..:.:..|                 :||
  Rat   904 EHWKTLMNRQDQELEK---------DMEADQTTLERKTLRRAMYS-----------------REA 942

  Fly   704 SLQMQE------------------TRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSA 750
            ..||::                  .|:..|:.......||||| .:|::|.|:|..|....:..|
  Rat   943 KAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWWYLTSG-GFFLLFLMIFSKLLKHSVIVA 1006

  Fly   751 ADYFLSYWVDK---NVDGQTDINTDPQDMYYFAALNV---AVVVFTIVRTMLFYKMAMRSSTQLH 809
            .||:|:.|..:   |..|:.|      ..:|.|..::   |.:...:|.::....|.:.::..||
  Rat  1007 IDYWLATWTSEYSINDPGKAD------QTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLH 1065

  Fly   810 NAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPY 874
            :.:...|....:.||:|.|.|.||||||.|...:|:.:|..:..:.:..|..|..|.:|....|.
  Rat  1066 HNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPV 1130

  Fly   875 YLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFD 939
            :||....|.:.||:|::::...|:|::.|:...:.|:..|.|.|..||.||||...:........
  Rat  1131 FLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML 1195

  Fly   940 NLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQ 1004
            .|.|.::..|....|.||......| :....||:......|:...:.|.|||.:..|:.:|..:.
  Rat  1196 ELTDTNNIAYLFLSAANRWLEVRTD-YLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLN 1259

  Fly  1005 WAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAK 1069
            |.:|..|:||..|.||::|..:..:|.|....:.:..:....||::|||...|||:||  :...|
  Rat  1260 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRY--ENNLK 1322

  Fly  1070 YVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISI 1133
            .|||.:...|:|.:||||.||||:|||||..|.||: ...:|.|.||..|.:.:.|..|||::||
  Rat  1323 PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSI 1387

  Fly  1134 IPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQL 1198
            |.|:|:|||||:|:||||..:..|.:||:|||..:||.::..||.||.:.::|||.|||||||||
  Rat  1388 ILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQL 1452

  Fly  1199 VCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDA 1263
            .|||||.:|::.:|:||||||::|..|:.::|..:.:.|.|.||:|||||::||:.:|.|:||..
  Rat  1453 FCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKR 1517

  Fly  1264 GHLVEFGSPYELLTSSESKIFHGMV 1288
            |:::|:.:| |.|.:.|..:|...|
  Rat  1518 GNILEYDTP-ESLLAQEDGVFASFV 1541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	428/1377 (31%)
		ABC_membrane	93..359	CDD:294371	83/293 (28%)
		ABCC_MRP_domain1	422..622	CDD:213217	90/246 (37%)
		ABC_membrane	735..978	CDD:294371	67/248 (27%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	111/221 (50%)
Abcc9	NP_037172.2	MRP_assoc_pro	222..1542	CDD:188098	432/1390 (31%)
Abcc9	NP_037172.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..963		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345045
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650