DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and abc2

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_593943.3	Gene:	abc2 / 2543193	PomBaseID:	SPAC3F10.11c	Length:	1478	Species:	Schizosaccharomyces pombe

Alignment Length:	1342	Identity:	442/1342 - (32%)
Similarity:	699/1342 - (52%)	Gaps:	134/1342 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKNETPRLGRALTKVF 85
            |.:.|.:..|::..|.:..|.:.|.:......:|.:|.......|.....|.::
pombe   199 SRISFGWLSPLMKFGYRNYLTESDAWSLPPAERSSNLTIVFEKNWISHAKKKKS----------- 252

  Fly    86 GFHLFITGVFLLAQEFLTKVTQPICLI-GVMAYFAGN-----------------DPDRSKAQLWA 132
              .|::.||..|....||.|...:.|: .|:|:...|                 .|.:....|..
pombe   253 --SLYMWGVLFLNHWKLTVVIIVLKLVQDVVAFIQPNLIRKIVIFVSSYSSEHPQPPQVGFSLAI 315

  Fly   133 AGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVG 197
            |..:...|.:..:...:.||:: |||:.|..|.:.||||:||||..|....:||.:||.:|.|..
pombe   316 AMFLTNVVQTALLQQYFQLGMV-LGMRWRSELITAIYRKSLRLSSAARQSRSVGDIVNYMSVDTQ 379

  Fly   198 RF-DLVLINVHYLWI---APLELI-AVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRL 257
            :. ||.:    :|::   .|.::: |:|.|.:| :|..::.|..:..|..|....:.......:.
pombe   380 KVCDLTM----FLFVIVSGPFQIVLALTNLYHL-VGYGALSGAFVTFLLFPCNVVIASIFKRFQN 439

  Fly   258 RTALRTDERVRMMNEIISGIQVIKMYAWEKPF-GKVVEMTRFNEMLCIKQVNYIRGILISFAMFL 321
            |.....|.|.:.|.|||:.|:.||:||||..| .|::::....|:..:|::..:..| .:|....
pombe   440 RQMKNKDARSQFMTEIINNIRSIKLYAWENIFLQKLLQLRNTRELRMLKKIGIVNTI-GNFTWLF 503

  Fly   322 SRIFTSSSLIA--FVLLG--NILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEA 382
            :.|..|::...  .||.|  .:|:.:..|...:.:|:|:..:|| .|..:|...|..|::.|:..
pombe   504 APILVSAATFGTFIVLYGKTRVLSVDIVFACLSLFNLLQFPLTM-LPIVVSSVLEASVAISRIYG 567

  Fly   383 FMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWE---SHSLEPTLEDIN 444
            |:...|.         ::|.....|....|.|     ..:|..:....|.   .::.||||.||:
pombe   568 FLTAGEL---------DSNAVQRYPANKEPSG-----VCLEIKKGTFSWSGPGQNAAEPTLRDID 618

  Fly   445 LQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGL 509
            ....|.:|..::|.||.|||||::|.||.:...||::...||.:||||:||:...|:::||||||
pombe   619 FVARRGELCCIVGKVGMGKSSLLEACLGNMQKHSGSVFRCGSIAYAAQQPWILNATIQENILFGL 683

  Fly   510 DWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPL 574
            :.|...|...::.|.|.||||:|..||:|.|||:|.|||||||||||||||||.|:|||||||.|
pombe   684 ELDPEFYEKTIRACCLLRDFEILADGDQTEVGEKGISLSGGQKARISLARAVYSRSDIYLLDDIL 748

  Fly   575 SAVDTHVGRHLFDQCM--RGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGL 637
            ||||.||.|.|....:  :|.|||..|||.|:.|..|::|.:|.::..|:|...|:
pombe   749 SAVDQHVNRDLVRNLLGSKGLLRSRCVILSTNSLTVLKEASMIYMLRNGKIIESGS--------- 804

  Fly   638 DFAQLLTAPNKD----AEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAES 698
             |.||.::|:..    ..:..:.|.|...|.|.....|.|...|.....|:.:.|..::|:..::
pombe   805 -FTQLSSSPDSQLFQLLSEFSKKDTASSTGADTPLSRSQSVITSSTDVTSSASRSSDTVSNYPKA 868

  Fly   699 MAQ---------------EASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILC 748
            ..:               :|:.|..|....||:...:|..|. ...|.|:||......:....:.
pombe   869 TIKGTGRIRKRLTDEDNVKATGQAAEKMERGKVKWKVYWTYF-KACSLFLIFLYFLFIIGGIGMN 932

  Fly   749 SAADYFLSYWVDKNVDGQTDINTDPQDMYY------FAALNVAVVVFTIVRTMLFYKMAMRSSTQ 807
            ...:.:|.:|.:.|    |.:..:|:..:|      |..|:.|::..:.:...:|  .|::|...
pombe   933 VGTNVWLKHWSEVN----TQLGYNPKPYFYLGIYTLFGLLSCALISLSSLTITVF--CAIKSCRY 991

  Fly   808 LHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITN 872
            ||::|.:.:.||.|.||.|.|:||||||||.|:.::|||:..|.:...:....::.::.|||.::
pombe   992 LHDSMVKAVLRAPMSFFETTPTGRILNRFSSDVYRVDEVISRVFMFFFRNLFQIVFVLAVICYSS 1056

  Fly   873 PYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAE 937
            |.::||.:.|..::.|.:.:|.:|||::|||::|.|||:|:|...::.||.||||...:...|:|
pombe  1057 PMFMILIVPLFFLYRYNQVYYTQTSRELKRLDSVTRSPLYAHFQESLGGLSTIRAYDMEDTFISE 1121

  Fly   938 FDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFI--------NPPQSPGEVGLAIT 994
            .|...|.:...::.:.::||.....::....|   ::..:.|.        ||  :.|.|||:::
pombe  1122 NDIRVDTNHRIWFLYFSSNRWQAIRVEAIGAL---VVFSSAFFGVLSAVRGNP--NSGLVGLSLS 1181

  Fly   995 QAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEF---DSREGKKPSPSWPEKGEIIAE 1056
            .|:.:|..:.:.:|||.::|..:.:|||::||..:..|...   |.|    |...||..|.|..:
pombe  1182 YAVQITQSLTFVVRQSVDVETNIVSVERMLEYIGLPSEAPSIIPDHR----PPEGWPSHGAIKFD 1242

  Fly  1057 DLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTA 1120
            ...:||  ......||..::..|:|.||:|||||||||||:|..||||| ....|.|.:|:.:..
pombe  1243 HYSVRY--RENLPLVLNDISVNIKPQEKIGIVGRTGAGKSTLTLALFRLIEPTSGDIQLDDINIT 1305

  Fly  1121 DMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKIS 1185
            .:||.||||:::|||||...|.|::|.||||.....|.::|.|||...||..|..|..||.|:::
pombe  1306 SIGLHDLRSRLAIIPQENQAFEGTIRENLDPNANATDEEIWHALEAASLKQFIQTLDGGLYSRVT 1370

  Fly  1186 EGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLN 1250
            |||:|.|.|||||:||.||:|...|||::|||||.||.:|||::|.|||.:|.|.|:||||||:|
pombe  1371 EGGANLSSGQRQLMCLTRALLTPTRVLLLDEATAAVDVETDAIVQRTIRERFNDRTILTIAHRIN 1435

  Fly  1251 TIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETG 1292
            |:|||:|:||:|.|.:|||.|..:|| .:::.:|:.:..|:|
pombe  1436 TVMDSNRILVLDHGKVVEFDSTKKLL-ENKASLFYSLAKESG 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	438/1325 (33%)
		ABC_membrane	93..359	CDD:294371	77/293 (26%)
		ABCC_MRP_domain1	422..622	CDD:213217	100/204 (49%)
		ABC_membrane	735..978	CDD:294371	70/248 (28%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	114/221 (52%)
abc2	NP_593943.3	MRP_assoc_pro	96..1477	CDD:188098	442/1342 (33%)
		ABC_membrane	272..545	CDD:279056	71/279 (25%)
		ABCC_MRP_domain1	593..798	CDD:213217	100/204 (49%)
		ABC_membrane	928..1190	CDD:279056	78/272 (29%)
		ABCC_MRP_domain2	1237..1456	CDD:213211	114/220 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720