DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and ybt1

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_594585.1	Gene:	ybt1 / 2542640	PomBaseID:	SPAC9E9.12c	Length:	1427	Species:	Schizosaccharomyces pombe

Alignment Length:	1358	Identity:	375/1358 - (27%)
Similarity:	647/1358 - (47%)	Gaps:	185/1358 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SMKADELPENPRERSSPLSSLMFCFAL--PVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCA-A 64
            ::|..::.....|::..:.||:|.:..  .:::|..||.:...|:         .:|.|..|. .
pombe   182 TVKFSKVARPSPEQTCSIFSLIFTYGWLNGIIWKSWKKPITLTDV---------PALPDTECTQI 237

  Fly    65 WDEQVAKNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQ 129
            |..:.|||:...|...:.......:.:. |||......|....|:.:..::.|......|...:.
pombe   238 WYSRFAKNDRKSLMHTILLSLKSTILLM-VFLSVLVSSTLFVTPLAIKKLLQYLQNPKSDEGNSP 301

  Fly   130 -LWAAGLIAGSVFSVCIGHPYMLGL-----LHLG----MKMRIALSSLIYRKALRLSRTAL---- 180
             ||        ||.:.|| ||:..:     :|:.    ::::.|::.:||:|.| .|:|..
pombe   302 FLW--------VFVLLIG-PYLASVVKELYVHVSRRFMLRIKAAITQMIYKKVL-TSKTLFVAVD 356

  Fly   181 -GDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPF 244
             ....:..|.|||:.||.....:...:..:..||||:....|.:|..:|.|:..|:.:.:|...|
pombe   357 GSKINLDYVYNLLAKDVDNIGEMREFIGIIARAPLEMGVSMYFLYQLLGWSAYVGLLLAILSSSF 421

  Fly   245 QSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKP-FGKVVEMTRF--NEMLCIKQ 306
            ...:..:.|.|.......:|||:|:..|::..|::.|::.||:| ..::.|...|  |.|..:..
pombe   422 PLLVASKISRLTSIANTSSDERIRLTTELLKSIKITKLFGWERPMLSRIQEKRSFEVNNMYSLTL 486

  Fly   307 VNYIRGILISFAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFA 371
            .:.|....:..|.|:|...|.:  |...::|:.|....||...:.:.:||... ::......:|.
pombe   487 FDIIFKSGMKIAPFISMFITFA--IYTKIMGHQLTPATAFTSISMFGLLRYQF-IWLASVSRQFI 548

  Fly   372 ELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFS-QFQARWESHS 435
            :..||::|::.|::                            ||.:.::.||.| .|.....|.|
pombe   549 QFKVSLKRVDNFVY----------------------------GNMVNDSSIESSDSFVFENTSLS 585

  Fly   436 LEPT-------LEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGEL---PGESGTLRINGSYSYA 490
            ..||       |:::|..:.|.:...|:|..|:|||:|..|:||||   .|:..|..|:...:|.
pombe   586 WSPTPSTALFQLKNLNFTIPRNQFTLVVGSTGSGKSTLAMALLGELHVISGKMTTPSISQRIAYV 650

  Fly   491 AQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARI 555
            .|..||..||:|.|||||..:|:.||..::|.|.|:.|...:..||.|.:...|:|||||||.|:
pombe   651 PQAAWLRNGTIRSNILFGEPYDEERYFQIIKACCLDSDLNSMNDGDLTYIHSNGSSLSGGQKQRV 715

  Fly   556 SLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQC-MRGYLRSELVILVTHQLQF-LEQADLIVIM 618
            |||||:|..|::|:.||..||:|....|.:::.| :...|:.:.:||.||.:.. |..|:.::::
pombe   716 SLARALYSNAEVYIFDDIFSALDVSTSRKIYESCFLSTLLQHKTIILFTHNVSLCLPIAENVIVL 780

  Fly   619 DKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPS--LSRRGSKNS- 680
            ....                 |||::     .:.:.|:            |||  .|....|::
pombe   781 KNST-----------------AQLVS-----PDSIQEL------------VPSTFFSSNTKKDNI 811

  Fly   681 -KPSTRNNSFTSLSSMAES--------MAQEASLQMQETRVEGKIGLGL-YKEYLTSGSSWFMIF 735
             :.:...:||:..|::|.|        .|..:|:.:          ||| |.:|.  ||:.: |.
pombe   812 EEENLEPHSFSFDSTLASSSDNDEQRDFASNSSIVL----------LGLHYLKYF--GSNKY-IL 863

  Fly   736 FMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKM 800
            ..:.|.:.:|:..::..::::.|...:: ....:.:....::.:|.|.....:..:.|.:.|.|.
pombe   864 GSILLVMMSQVSLASIHFWIALWSGNSL-FSLKLPSSFSFLWGYAILLFIYFLMDLSRAITFAKG 927

  Fly   801 AMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEV----LPSVMLDVVQLFLTL 861
            ...:|..:|:.:.:.:..:.:::|....:||||||||||:...|.:    |..::|.|:.:.:|:
pombe   928 GRTASENIHDILSERVLYSPLHWFEKTAAGRILNRFSKDMYATDNLLWASLEGMLLCVMAILITM 992

  Fly   862 LGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIR 926
            |.:.:|:    |.:::....::::.|.....|.|..:.:..|::...||:::.|..|:.|:..||
pombe   993 LNVTLVM----PIFMVPAAFVSLLVYLHGYAYSKAQKQLTSLQSSRTSPVFTMLGETLGGITVIR 1053

  Fly   927 ALGAQKELIAEFDN---LQDLHSSGYYTFLATNRAFGYYLD------CFCTLYIVIIILNYFINP 982
            |.  :||.|.|.:|   :.|:....|.:| |.||......|      .|.|..|.::..|.
pombe  1054 AF--KKEKIFEHENMAFIDDMIQPLYISF-AINRWLAIRTDGISGLVGFSTGLIALLRQNI---- 1111

  Fly   983 PQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSW 1047
              .||.||.::..|:|....|...:|.:.|:...:....|:.||..:..|....|...|..:..|
pombe  1112 --PPGLVGFSLNSAIGFNISVLVFVRANNEILTYINNFRRLYEYMLLPSEKNESSCLTKPMNKEW 1174

  Fly  1048 PEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLS-YNEGI 1111
            |..|.:..::|.:.|.....|  ||:.:|..|.|.||:.||||||:|||::...|.|.: ...|.
pombe  1175 PTLGHVSIKNLTVSYSIGQAA--VLEDINLEILPKEKIAIVGRTGSGKSTMGLTLLRFTMIMSGA 1237

  Fly  1112 ITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISEL 1176
            :.:|..|...:.|..||.:||:|||:|||.||::|.||||||||.|.:|.:.|:....:.|:...
pombe  1238 VEVDGIDINSLDLEVLRQRISLIPQDPVLISGTVRSNLDPFEEYGDGELNEILKTASCESLVQAS 1302

  Fly  1177 PNG--------LQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATI 1233
            ...        |.:.:..||.|||.||||::.||||::|::|::::||:||:||..||..||..:
pombe  1303 NKNSLDAFAIHLDTPVDSGGVNFSSGQRQILALARALVRKSRIVILDESTASVDDTTDRRIQQML 1367

  Fly  1234 RSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMET 1291
            |:.|:..|||.||||:.||:|.|:|||:|:|..||||||..|.|  :.:.|..|..|:
pombe  1368 RAAFKHATVLCIAHRIKTIVDYDKVLVLDSGKTVEFGSPKSLYT--QRRAFWKMCKES 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	370/1333 (28%)
		ABC_membrane	93..359	CDD:294371	68/283 (24%)
		ABCC_MRP_domain1	422..622	CDD:213217	79/212 (37%)
		ABC_membrane	735..978	CDD:294371	56/255 (22%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	99/229 (43%)
ybt1	NP_594585.1	CFTR_protein	192..1416	CDD:273530	371/1339 (28%)
		ABC_membrane	266..537	CDD:294371	68/282 (24%)
		ABCC_MRP_domain1	577..782	CDD:213217	76/204 (37%)
		ABC_membrane	866..1094	CDD:294371	53/235 (23%)
		ABCC_MRP_domain2	1178..1406	CDD:213211	99/229 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810