DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and Abcc2

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_036965.1	Gene:	Abcc2 / 25303	RGDID:	2366	Length:	1541	Species:	Rattus norvegicus

Alignment Length:	1389	Identity:	475/1389 - (34%)
Similarity:	747/1389 - (53%)	Gaps:	154/1389 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAK---- 71
            :.|...:|.|||:.|.:....:.||.|..|..:|::...:..|:.|:..:..||..:.:.|
  Rat   191 QTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQA 255

  Fly    72 --------------------------------NETPRLGRALTKVFGFHLFITGVF-----LLAQ 99
                                            .|..:.....||.:.....|..:|     ::.:
  Rat   256 FQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKTFHVVILK 320

  Fly   100 EFLTKVTQPI----------CLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFSV------CIGHP 148
            .|:.|:...:          .|||.:        ..|.:.:|...:.|..:|:|      |: ..
  Rat   321 SFILKLIHDLLVFLNPQLLKLLIGFV--------KSSNSYVWFGYICAILMFAVTLIQSFCL-QS 376

  Fly   149 YMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAP 213
            |......|||.:|..:.|.||:|||.||..|....|:|:.|||:|.|..:.......:..:|.:.
  Rat   377 YFQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSV 441

  Fly   214 LELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQ 278
            :::....:.::.|:|.|.:.||.:|:|.:|....|..:...::::.....|:|:::||||:|||:
  Rat   442 IQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIK 506

  Fly   279 VIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTS---SSLIAFVLLGNIL 340
            ::|.:|||..|.:.|:..|..|:..:.:...::.:|| |.:.::.|..|   .|:...|...|:|
  Rat   507 ILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLI-FILQITPILVSVVTFSVYVLVDSANVL 570

  Fly   341 NAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAE 405
            ||||||.....:||||..::| .|...|...:..|||.|||.::...:.......:|.|.
  Rat   571 NAEKAFTSITLFNILRFPLSM-LPMVTSSILQASVSVDRLERYLGGDDLDTSAIRRVSNF----- 629

  Fly   406 SPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAI 470
                         :..::||:....|:. .||.|::|:||.:...:||||:|.||:|||||:.|:
  Rat   630 -------------DKAVKFSEASFTWDP-DLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLVSAM 680

  Fly   471 LGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFG 535
            |||:....|.:.|.||.:|..|:.|:..||::.|||||.::::.:|:.|:|.|||..|.|:||.|
  Rat   681 LGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKACALLPDLEILPGG 745

  Fly   536 DKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSEL 598
            |...:||:|.:||||||.|:|||||.|:.||||:|||||||||.|||:|:|::.:  .|.|..:.
  Rat   746 DMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLAGKT 810

  Fly   599 VILVTHQLQFLEQADLIVIMDKGRISAMGTY---------------SSMKRSGLDFAQLLTAPNK 648
            .|.|||.:.||.|.|.||::.||.|...|:|               :.||.||.:....:   |.
  Rat   811 RIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFMKHSGPEGEATV---NN 872

  Fly   649 DAEDLDEIDG---------AGGDGLDLLNVPSLSRRGSKNSKPSTR-----NNSF----TSLSSM 695
            |:|..|:.||         .....|.:....||.|..|::|:.|:|     .||.    .::...
  Rat   873 DSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSLKNSLKIKNVNVLKE 937

  Fly   696 AESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWV- 759
            .|...:...|..:|....||:...:|.:||.:...|.::|.::|..| ..:....::.:||.|.
  Rat   938 KEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSILFIILFYGL-NNVAFIGSNLWLSAWTS 1001

  Fly   760 -DKNVDGQTDINTDPQDMY--YFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAM 821
             ..|::| |:.::..:||.  .|.||.:|..:..::.|:........:|..||..:...|.||.|
  Rat  1002 DSDNLNG-TNNSSSHRDMRIGVFGALGLAQGICLLISTLWSIYACRNASKALHGQLLTNILRAPM 1065

  Fly   822 YFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIF 886
            .||:|.|:|||:||||.|:..:|::||..:...:..|..:.|.:|:||:..|.:.|:.:.|:|::
  Rat  1066 RFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILY 1130

  Fly   887 YYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYT 951
            ..::.||:.|||.::||::|.:||||||.|.|:||||.|||...|:..:|..:...|::....::
  Rat  1131 ISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFS 1195

  Fly   952 FLATNRAFGYYLD------CFCTLYIVIIILNYFINPPQSPGE-VGLAITQAMGMTGMVQWAMRQ 1009
            ::.:||.....|:      .||:..:::|.....      .|: ||..::.|:.:|..:.|.:|.
  Rat  1196 WITSNRWLAIRLELVGNLVVFCSALLLVIYRKTL------TGDVVGFVLSNALNITQTLNWLVRM 1254

  Fly  1010 SAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKA 1074
            ::|.|..:.||||:.||..:|.|..:.:  .|:|...||..|||...:..:||  .|:...|||.
  Rat  1255 TSEAETNIVAVERISEYINVENEAPWVT--DKRPPADWPRHGEIQFNNYQVRY--RPELDLVLKG 1315

  Fly  1075 LNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEP 1138
            :...|:..||||:|||||||||||.|.||| |....|.|.||..|.|.:||.|||.:::||||:|
  Rat  1316 ITCNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDP 1380

  Fly  1139 VLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLAR 1203
            :|||||:|.|||||.:|:|.::|.|||...|:..:|.|..||.|:::|||.|.|:|||||:||.|
  Rat  1381 ILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGR 1445

  Fly  1204 AILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVE 1268
            |:||::::||:|||||.||.:||:|||.|||.:|..|||:||||||:||||||:::|:|.|.:||
  Rat  1446 AVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVE 1510

  Fly  1269 FGSPYELLTSSESKIFHGMVMETG 1292
            :|||.|||::..|  |:.|..|.|
  Rat  1511 YGSPEELLSNRGS--FYLMAKEAG 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	469/1371 (34%)
		ABC_membrane	93..359	CDD:294371	79/289 (27%)
		ABCC_MRP_domain1	422..622	CDD:213217	98/201 (49%)
		ABC_membrane	735..978	CDD:294371	79/252 (31%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	124/221 (56%)
Abcc2	NP_036965.1	MRP_assoc_pro	7..1533	CDD:188098	475/1389 (34%)
		ABC_membrane	322..589	CDD:279056	78/276 (28%)
		ABCC_MRP_domain1	633..834	CDD:213217	98/201 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..881		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..923		7/21 (33%)
		ABC_membrane	979..1245	CDD:279056	82/273 (30%)
		ABCC_MRP_domain2	1294..1514	CDD:213211	124/221 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345107
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660