Protein Alignment Mrp4 and Tap1

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_114444.2
• Gene: Tap1 / 24811
• RGDID: 3817
• Length: 725
• Species: Rattus norvegicus
• Alignment Length: 576
• Identity: 138/576 - (23%)
• Similarity: 248/576 - (43%)
• Gaps: 73/576 - (12%)

  Fly   740 LCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQDMYYFAALNVAVVVFTIVRTML------FY 798
            |.|...||....:..:.::..:..|......|.|.    ||.....:.:.|:..|.|      .|
  Rat   166 LVLVLLILSCLGEMAIPFFTGRITDWILQDKTAPS----FARNMWLMCILTVASTALEFAGDGIY 226

  Fly   799 KMAM-RSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLL 862
            .:.| ...:::|..:::.:......||..||:|.|.:|.::|...:.|.:.    |.:.|||..|
  Rat   227 NITMGHMHSRVHGEVFRAVLHQETGFFLKNPTGSITSRVTEDTSNVCESIS----DKLNLFLWYL 287

  Fly   863 G---IIVVICITNPYYL--ILTLALAIIFYYIREF-YLKTSRDVKRLEAVARSPIYSHLSATITG 921
            |   .::...|...:||  :..|:|.::|...|.. .:..|..||..|::|:|...: |.| ::.
  Rat   288 GRGLCLLAFMIWGSFYLTVVTLLSLPLLFLLPRRLGKVYQSLAVKVQESLAKSTQVA-LEA-LSA 350

  Fly   922 LPTIRALG-----AQK--ELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIIL--N 977
            :||:|:..     |||  :.:.|...|....:..|.|.:.|....|..|.      :.|:.|  .
  Rat   351 MPTVRSFANEEGEAQKFRQKLEEMKPLNKKEALAYVTEVWTMSVSGMLLK------VGILYLGGQ 409

  Fly   978 YFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKK 1042
            ..:....|.|.:...:...:..|..|:..:.....::.::.|.|::.||.:..|
  Rat   410 LVVRGAVSSGNLVSFVLYQLQFTRAVEVLLSIYPSMQKSVGASEKIFEYLDRTP----------- 463

  Fly  1043 PSP------SWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINA 1101
            .||      ....||.:..:|:...|...|..: ||:.|.|.:.|.:...:||..|:|||: :.|
  Rat   464 CSPLSGSLAPLNMKGLVKFQDVSFAYPNHPNVQ-VLQGLTFTLYPGKVTALVGPNGSGKST-VAA 526

  Fly  1102 LFRLSYNE--GIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDAL 1164
            |.:..|..  |.:.:|...........|.::::.:.|||:||..|.|.|:    .|...:. ..:
  Rat   527 LLQNLYQPTGGKVLLDGELLVQYDHHYLHTQVAAVGQEPLLFGRSFRENI----AYGLTRT-PTM 586

  Fly  1165 EEVKLKPL-------ISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVD 1222
            ||:....:       ||..|.|..:::.|.|:..|.||||.|.||||::|:.|:|::|:||:.:|
  Rat   587 EEITAVAMESGAHDFISGFPQGYDTEVGETGNQLSGGQRQAVALARALIRKPRLLILDDATSALD 651

  Fly  1223 PQTDALIQATI--RSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELL 1276
            ......:|..:  ..::...|||.|..:|:....:..:|.:..|.:.|.|:..:|:
  Rat   652 AGNQLRVQRLLYESPEWASRTVLLITQQLSLAERAHHILFLKEGSVCEQGTHLQLM 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	138/576 (24%)
		ABC_membrane	93..359	CDD:294371
		ABCC_MRP_domain1	422..622	CDD:213217
		ABC_membrane	735..978	CDD:294371	60/259 (23%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	65/231 (28%)
Tap1	NP_114444.2	3a01208	2..717	CDD:273363	138/576 (24%)
		ABC_membrane	177..435	CDD:279056	59/273 (22%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518	352..397		11/44 (25%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518	430..464		7/44 (16%)
		P-loop_NTPase	469..697	CDD:304359	64/234 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000