Protein Alignment Mrp4 and Abcc1

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_071617.2
• Gene: Abcc1 / 24565
• RGDID: 3112
• Length: 1532
• Species: Rattus norvegicus
• Alignment Length: 1392
• Identity: 492/1392 - (35%)
• Similarity: 741/1392 - (53%)
• Gaps: 182/1392 - (13%)

  Fly    13 PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAW------------ 65
            |...:|.||.:.|.:...::.:|.::.|:..||:...||..|:.:...|...|
  Rat   209 PESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVKSRKQPV 273

  Fly    66 ---------------------DEQVA--------KNETPRLGRALTKVFGFHLFITGVFLLAQEF 101
                                 :|:|.        |:..|.|.:.|.|.||.:      ||::  |
  Rat   274 RIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPY------FLMS--F 330

  Fly   102 LTKVTQPICLIGVMAYFAG-----------ND---PDRSKAQLWAAGLIAGSVF-SVCIG----H 147
            |.|....:.:      |||           ||   ||      |...|....:| |.|:.    |
  Rat   331 LYKALHDLMM------FAGPEILELIINFVNDREAPD------WQGYLYTALLFVSACLQTLALH 383

  Fly   148 PYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIA 212
            .|.......||:::.|:...:|||||.::.:|...:|||::|||:|.|..||..:...::.:|.|
  Rat   384 QYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 448

  Fly   213 PLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGI 277
            ||::....|.::|.:|.|.:.|||:|:|.:||.:.:..:|...::......|.|:::||||::||
  Rat   449 PLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGI 513

  Fly   278 QVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGI-------------LISFAMFLSRIFTSSS 329
            :|:|:||||..|...|...|..|:..:|:..|:..:             |.:||:|::
  Rat   514 KVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVT------- 571

  Fly   330 LIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVR-- 392
                |...|||:|:|||...|.:||||..:.: .|..||...:..||::||..|:...|.:..
  Rat   572 ----VDEKNILDAKKAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELEPDSI 631

  Fly   393 DKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIG 457
            ::..:|:              |.|:  |.|........| :....|||..|...:....||||:|
  Rat   632 ERWSIKD--------------GGGM--NSITVKNATFTW-ARDEPPTLNGITFAIPDGALVAVVG 679

  Fly   458 PVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKK 522
            .||.|||||:.|:|.|:....|.:.:.||.:|..|:.|:...::|:|||||....:|.|:.|::.
  Rat   680 QVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEA 744

  Fly   523 CALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFD 587
            |||..|.|:||.||.|.:||:|.:||||||.|:|||||||..:|||||||||||||.|||:|:|:
  Rat   745 CALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFE 809

  Fly   588 QCM--RGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSS-MKRSGLDFAQLLTAPNKD 649
            :.:  .|.|:::..|||||.:.:|.|.|:|::|..|:||.||:|.. :.|.|. ||:.:......
  Rat   810 KVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGA-FAEFVRTYANT 873

  Fly   650 AEDL----DEIDGAGGDG------------LDLLNVPSLSRRGSKNSKPS-TRNNSFTSLSSMAE 697
            .:||    |..:|..|.|            .|.:..| |.|..|.:|..| ..|...:|.:.:.:
  Rat   874 EQDLASEDDSKNGVSGLGKESKPVENGILVTDAVGKP-LQRHLSNSSSHSVVTNQQHSSTAELQK 937

  Fly   698 SMAQEASLQMQET--RVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVD 760
            |..:|.:.::.|.  ...|::.|.:|..|: ......:.|..:||.|...:...|::|:||.|.|
  Rat   938 SGVKEETWKLMEADKAQTGQVKLSVYWNYM-KAIGLCISFLSIFLFLCNHVSALASNYWLSLWTD 1001

  Fly   761 KN--VDGQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMR-----SSTQLHNAMYQGITR 818
            ..  |:|..:.......:|....:...|.||.       |.||:.     :|.:||..:.|.:.|
  Rat  1002 DRPAVNGTQENRNFRLSVYGALGILQGVAVFG-------YSMAVSIGGIFASRRLHLDLLQNVLR 1059

  Fly   819 AAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALA 883
            :.|.||...|||.::|||||:|..:|.::|.|:...:....:::|.:::|.:..|...::...|.
  Rat  1060 SPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLG 1124

  Fly   884 IIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSG 948
            :::::::.||:.:||.:||||:|:|||:|||.:.|:.|:..|||...|:..|.:.|...|.:...
  Rat  1125 LVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKA 1189

  Fly   949 YYTFLATNRAFGYYLDC-------FCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWA 1006
            ||..:..||.....|:|       |..|:.||      .....|.|.|||:::.::.:|..:.|.
  Rat  1190 YYPSIVANRWLAVRLECVGNCIVLFAALFAVI------SRHSLSAGLVGLSVSYSLQITAYLNWL 1248

  Fly  1007 MRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYV 1071
            :|.|:|:|..:.||||:.||.|.|.|..:..:|...|| :||..|.:...|.||||..|  ...|
  Rat  1249 VRMSSEMETNIVAVERLKEYSETEKEASWQIQETAPPS-TWPHSGRVEFRDYCLRYRED--LDLV 1310

  Fly  1072 LKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYN-EGIITIDERDTADMGLFDLRSKISIIP 1135
            ||.:|..|...||||||||||||||||...|||::.: ||.|.||..:.|.:||.:||.||:|||
  Rat  1311 LKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIP 1375

  Fly  1136 QEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVC 1200
            |:|||||||:|.|||||.:|:|.::|.|||...||..:|.||:.|..:.:|||.|.|||||||||
  Rat  1376 QDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVC 1440

  Fly  1201 LARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGH 1265
            ||||:||:.::||:|||||.||.:||.|||:|||::|.|.||||||||||||||..||:|:|.|.
  Rat  1441 LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGE 1505

  Fly  1266 LVEFGSPYELLTSSESKIFHGMVMETG 1292
            :.|.|:|.|||  .:..:|:.|..:.|
  Rat  1506 IRECGAPSELL--QQRGVFYSMAKDAG 1530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	491/1390 (35%)
Abcc1	NP_071617.2	MRP_assoc_pro	7..1531	CDD:188098	492/1392 (35%)