DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and Abcc12

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_766500.3	Gene:	Abcc12 / 244562	MGIID:	2441679	Length:	1366	Species:	Mus musculus

Alignment Length:	1387	Identity:	448/1387 - (32%)
Similarity:	723/1387 - (52%)	Gaps:	157/1387 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPENPRERSSP--------LSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAW 65
            :|..||.|.:|        ||...|.:..||:.:..|.||....|........||....|....|
Mouse    33 IPVRPRARLAPNPVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDSSDINAKRFQILW 97

  Fly    66 DEQVAK--NETPRLGRALTK-------------VFGFHLFITGVFLLAQEFLTKVTQ-------- 107
            :|::.:  .|...|||.:.|             :....:...|..:|..:.|..:|.
Mouse    98 EEEIKRVGPEKASLGRVVWKFQRTRVLMDVVANILCIVMAALGPTVLIHQILQHITSISSGHIGI 162

  Fly   108 PICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKA 172
            .|||  .:|.|.   .:.:|...||   :|.::            .....:::::|||:||:...
Mouse   163 GICL--CLALFT---TEFTKVLFWA---LAWAI------------NYRTAIRLKVALSTLIFENL 207

  Fly   173 LRLSRTALGDTTVGQVVNLLSND-VGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVA 236
              ||...|...:.|:|:|:||:| ...|:..|.......|..|.::...|..:: :|.:::.|::
Mouse   208 --LSFKTLTHISAGEVLNILSSDSYSLFEAALFCPLPATIPILMVVCAVYAFFI-LGSTALVGIS 269

  Fly   237 IMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEM 301
            :.|:|:|.|.::.|..|..|......||:||:.|||.::.|::|||||||:.|...:...|..|.
Mouse   270 VYLIFIPIQMFMAKLNSTFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEESFINTIHDIRKREK 334

  Fly   302 LCIKQVNYIRGILISFAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQG 366
            ..:::..|::....:.|..:|.|...|:....:.|...|.|..||.|.|.:|:::.|:.: .|..
Mouse   335 KLLEKAGYVQSGNSALAPIVSTIAIVSTFTCHIFLKRKLTAPVAFSVIAMFNVMKFSIAI-LPFS 398

  Fly   367 ISEFAELLVSVRRLE---------AFMHRPETKVRDKSKV-----------KNANQKAESPNGDS 411
            :...||..||:||::         :::.:||    |...:           :..|:|::.|....
Mouse   399 VKAVAEASVSLRRMKKILIAKSPPSYITQPE----DPDTILLLANATLTWEQEINRKSDPPKAQI 459

  Fly   412 PKGNGIPENLIEFSQFQAR---------WESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLI 467
            .|.:...:...|....|:|         |:|.|.:..|.:|:..:.:.|::.:.|.||:||||||
Mouse   460 QKRHVFKKQRPELYSEQSRSDQGVASPEWQSGSPKSVLHNISFVVRKGKVLGICGNVGSGKSSLI 524

  Fly   468 QAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELL 532
            .|:||::..:.|.:.:||..:|.:|:.|:|.|.||:|||||..::..||:..|..|.|::|...|
Mouse   525 SALLGQMQLQKGVVAVNGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNSL 589

  Fly   533 PFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSE 597
            |:||.|.:||||.:|||||:.|||||||||....:|||||||||||.|||:|:|::|::..|:.:
Mouse   590 PYGDLTEIGERGVNLSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEECIKKTLKGK 654

  Fly   598 LVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRS------------GLDF---------AQ 641
            .|:||||||||||..|.:::::.|.|...||:..:...            ||.|         |.
Mouse   655 TVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHIYNVAM 719

  Fly   642 LLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQ 706
            :.|.....|:..::...|.||..|            :..:|.|  ..|...::.|..:.|..|.|
Mouse   720 VETLKESPAQRDEDAVLASGDEKD------------EGKEPET--EEFVDTNAPAHQLIQTESPQ 770

  Fly   707 MQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAA--DYFLSYWVDK-------N 762
                  ||.:....|..|: ..|..:::.|:| |||...::.|:|  .::|..|:|:       :
Mouse   771 ------EGIVTWKTYHTYI-KASGGYLVSFLV-LCLFFLMMGSSAFSTWWLGIWLDRGSQVVCAS 827

  Fly   763 VDGQTDINTDP--QD----MY---YFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITR 818
            .:.:|..|.|.  ||    ||   |.|:: |:|::|.|::...|....:.:|:.|||.::..|.|
Mouse   828 QNNKTACNVDQTLQDTKHHMYQLVYIASM-VSVLMFGIIKGFTFTNTTLMASSSLHNRVFNKIVR 891

  Fly   819 AAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALA 883
            :.|.||:|.|:||::||||||:.:||..||....:.:|.|..::.|:|::....|..|::...||
Mouse   892 SPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVIMAAVFPVVLVVLAGLA 956

  Fly   884 IIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSG 948
            :||..:...:.:..:::|::|.::|||.:||::::|.||..|.|...:.:.|::|..|.|.:||.
Mouse   957 VIFLILLRIFHRGVQELKQVENISRSPWFSHITSSIQGLGVIHAYDKKDDCISKFKTLNDENSSH 1021

  Fly   949 YYTFLATNRAFGYYLDCFCTLYIVIIILNYFIN-PPQSPGEVGLAITQAMGMTGMVQWAMRQSAE 1012
            ...|....|.|...:|....:...::.|...:: ...|....||:::..:.::|::|..:|...|
Mouse  1022 LLYFNCALRWFALRMDILMNIVTFVVALLVTLSFSSISASSKGLSLSYIIQLSGLLQVCVRTGTE 1086

  Fly  1013 LENTMTAVERVVEYD-EIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALN 1076
            .:...|:.|.:.||. ...||.....:.|..|. .||.:|||..:|..:||  ......||..||
Mouse  1087 TQAKFTSAELLREYILTCVPEHTHPFKVGTCPK-DWPSRGEITFKDYRMRY--RDNTPLVLDGLN 1148

  Fly  1077 FRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVL 1140
            ..|:..:.||||||||:|||||..||||| ....|.|.|||.|...:||.|||:|:::|||:|||
Mouse  1149 LNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIIIDEVDICTVGLEDLRTKLTMIPQDPVL 1213

  Fly  1141 FSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAI 1205
            |.|::||||||...:.|..||..||...::..|.:||..||::::|.|.|||||:|||:|:|||:
Mouse  1214 FVGTVRYNLDPLGSHTDEMLWHVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCMARAL 1278

  Fly  1206 LRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFG 1270
            ||.::::::|||||::|.:||.|:|:||:..|:.||||||||||||:::.|.||||:.|.::||.
Mouse  1279 LRNSKIILLDEATASMDSKTDTLVQSTIKEAFKSCTVLTIAHRLNTVLNCDLVLVMENGKVIEFD 1343

  Fly  1271 SPYELLTSSESKIFHGMVMETG 1292
            .|..|....:|.....:..|.|
Mouse  1344 KPEVLAEKPDSAFAMLLAAEVG 1365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	444/1367 (32%)
		ABC_membrane	93..359	CDD:294371	72/274 (26%)
		ABCC_MRP_domain1	422..622	CDD:213217	95/208 (46%)
		ABC_membrane	735..978	CDD:294371	80/260 (31%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	114/221 (52%)
Abcc12	NP_766500.3	MRP_assoc_pro	43..1366	CDD:188098	444/1377 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..492		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..749		5/34 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841703
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660