Protein Alignment Mrp4 and Abcc10

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_001334325.1
• Gene: Abcc10 / 224814
• MGIID: 2386976
• Length: 1526
• Species: Mus musculus
• Alignment Length: 1372
• Identity: 425/1372 - (30%)
• Similarity: 679/1372 - (49%)
• Gaps: 156/1372 - (11%)

  Fly    11 ENPRERSSPLSSLMFCFALPVLFKGRKKTLEQ-KDLYRALKEHKSDSLGDRLCAAWDEQVAKNET 74
            |...:..|.||...:.:..|:|.:|.:..|:| :|..|..:......|.....|.|      .|.
Mouse   213 EVAEDGESWLSRFSYAWLAPLLARGVRGELQQPRDTCRLPRRLHPAFLARVFQAHW------KEG 271

  Fly    75 PRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGS 139
            .:|.|||.:.||......|:..:....| ..:.|:.|..::.:........|...|:..||..|:
Mouse   272 AQLWRALYRAFGCCYLALGLLKMVGTML-GFSGPLLLSLLVGFLEEGQEPLSHGLLYVLGLAGGT 335

  Fly   140 VFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLI 204
            |.|..:.:.|...:..:.::.|:|:.|.:|||||:|..:.   ...|:|:|||..|..|    |:
Mouse   336 VISAVLQNQYGYEVRKVTLQARVAVLSTLYRKALKLGPSR---PPTGEVLNLLGTDSER----LL 393

  Fly   205 N----VHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDE 265
            |    .|..|..||:|....||:|.::|::.:.|:.:.||.:|....:..|............|.
Mouse   394 NFAGSFHEAWGLPLQLAITLYLLYQQVGMAFLAGLVLALLLVPVNKVIATRIMASNQEMLRHKDA 458

  Fly   266 RVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTSSSL 330
            ||::|.|::|||:|||.:.||:..|..|:..|..|:..::.:.|:....:.....|..:...:..
Mouse   459 RVKLMTELLSGIRVIKFFRWEQALGDRVKACRTKELGRLRVIKYLDAACVYLWAALPVVICITIF 523

  Fly   331 IAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKS 395
            |.:||:|:.|.|.|.|...|...:|...:.. ||..|:...|..||:.|::.|:..|
Mouse   524 ITYVLMGHQLTATKVFTALALVRMLILPLNN-FPWVINGLLESKVSLDRIQRFLDLP-------- 579

  Fly   396 KVKNANQKAESPNG-DSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPV 459
                    :.||.. .||.....|...:|..:....|:...........:||:.:..||.::|.|
Mouse   580 --------SYSPEAYYSPDPPAEPSTALELHEALFSWDPIGASQKTFISHLQVKKGMLVGIVGKV 636

  Fly   460 GAGKSSLIQAILGELP---GESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVK 521
            |.|||||:.||.|||.   |......::..:..|.||||:...|:|.|||||..:|...||.|::
Mouse   637 GCGKSSLLAAITGELHRLCGWVAVSELSKGFGLATQEPWIQCATIRDNILFGKTFDAQLYREVLE 701

  Fly   522 KCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLF 586
            .|||..|..:||.||:|.|||:|.:|||||:|||:||||||:...:|||||||:|||..|..||.
Mouse   702 ACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALYLLDDPLAAVDADVANHLL 766

  Fly   587 DQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAE 651
            .:|:.|.|.....:|.||:.::||:||::::|:.|::...|..|.:    |...|.:.....:.|
Mouse   767 HRCILGVLSHTTRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSEI----LPLVQAVPTAWAEKE 827

  Fly   652 DLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKI 716
            .:                      .:....||..:...|:...:....:....|..:|::.||.:
Mouse   828 QV----------------------ATSGQSPSVCDLERTTEEELEVEQSTCGCLVQEESKSEGAV 870

  Fly   717 GLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDP-------- 773
            .|.:|:.|..:..|......:|.| |..|...:.||::|::|:.:...|:.....||
Mouse   871 ALHVYRAYWRAMGSGLAAAILVSL-LLMQATRNGADWWLAHWLSQLKAGRNGSREDPASCSPGST 934

  Fly   774 --------------------------------QDMYYFAALNVAVV----VFTIVRTMLFYKMAM 802
                                            .|::::..:...:.    :.|::|.:||...|:
Mouse   935 ALFSPRLLLFSPGNLYTPLLSTPLHKAASNGTADVHFYLIVYATIAGVNSLCTLLRAVLFAAGAL 999

  Fly   803 RSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVV 867
            :::..||:.:...:..|.:.|:::.||||:|||||.|:..:|:.||.::..::...:.|||::.|
Mouse  1000 QAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGLLGLLAV 1064

  Fly   868 ICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQK 932
            :....|:.|:|...|:.::|.::.:|..:.|:::||.::..||:||||:.|:.|||.:||.||..
Mouse  1065 LGSGLPWLLLLLPPLSFVYYSVQGYYRASFRELRRLGSLTWSPLYSHLADTLAGLPVLRAAGATY 1129

  Fly   933 ELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLY---IVIIILNYFINPPQ----SPGEVG 990
            ....|...|.:|:....:...||.:    :||....|.   :|..|....:...|    :||.||
Mouse  1130 RFEEENQRLLELNQRCQFASYATMQ----WLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVG 1190

  Fly   991 LAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSP---SWPEKGE 1052
            |.::.|:.:||::...:....:.|..|.:|||:.||....|: |..|:..:.|..   ||..:|.
Mouse  1191 LVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDVPQ-EPHSQPLQSPHQQRISWLTQGS 1254

  Fly  1053 IIAEDLCLRYFPD-PQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIITID 1115
            :..:|:.|.|.|. |.|   |..:.||:.|.||:|||||||:|||||...||| |..|.|.:.:|
Mouse  1255 VEFQDVVLVYRPGLPNA---LDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPNAGRVLLD 1316

  Fly  1116 ERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLI------- 1173
            ..||:.:.|.:|||::::|||||.||||::|.||||...:.|..||.|||:..|..:.
Mouse  1317 NVDTSQLELAELRSQLAVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCHLSEVAVAMGESQ 1381

  Fly  1174 -----------------SELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANV 1221
                             :.|..||..::.|.|.|.|:|||||:|||||:|.:.::|.:|||||:|
Mouse  1382 ACQRSQREAKNGHWQCSALLTGGLDGELGERGQNLSLGQRQLLCLARALLTDAKILCIDEATASV 1446

  Fly  1222 DPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHG 1286
            |.:||.|:|.||..:|.:.||||||||||||::||||||:.||.:||..||..|.....| :|..
Mouse  1447 DQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQPHS-LFQQ 1510

  Fly  1287 MVMETGQ 1293
            ::..:.|
Mouse  1511 LLQSSQQ 1517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	423/1367 (31%)
Abcc10	NP_001334325.1	MRP_assoc_pro	203..1503	CDD:188098	422/1355 (31%)