DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and Abcc8

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	XP_036008753.1	Gene:	Abcc8 / 20927	MGIID:	1352629	Length:	1597	Species:	Mus musculus

Alignment Length:	1451	Identity:	441/1451 - (30%)
Similarity:	718/1451 - (49%)	Gaps:	229/1451 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPRERSSP--LSSLMFCFALP---VLFKGRK-------KTLEQKDL-----------YRALKEH 52
            :.|||...|  |..|...|..|   :|.||..       ||..:|.:           .|||..:
Mouse   199 KTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHRKPIDLRAIGKLPIAMRALTNY 263

  Fly    53 KSDSLGDRLCAAWDEQVAKNETPRLG-----RALTKVFGFHLFITGVFLLAQEFLTKVTQPICLI 112
            :      |||||:|.|..|:...:.|     |||...||..|.::..|.:..:.| ....|:|:.
Mouse   264 Q------RLCAAFDAQARKDTQSQQGARAIWRALCHAFGRRLVLSSTFRILADLL-GFAGPLCIF 321

  Fly   113 GVMAYFA-GNDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLGLL--------------------HL 156
            |::.:.. .|...:.|.|......::...|   :|:.|:|.:|                    ..
Mouse   322 GIVDHLGKENHVFQPKTQFLGVYFVSSQEF---LGNAYVLAVLLFLALLLQRTFLQASYYVAIET 383

  Fly   157 GMKMRIALSSLIYRKALRLSRT--ALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAV 219
            |:.:|.|:.:.||.|.:.||.:  ::|:.|.||:.||::.|..:..........||..|:::|..
Mouse   384 GINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVG 448

  Fly   220 TYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYA 284
            ..|:|..:|:|::.|.|:::|..|.|.::..:.|..:..|...::||::..||::.||:::|:||
Mouse   449 VILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYA 513

  Fly   285 WEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLS-RIFTSSSL-IAFVLL---GNI----- 339
            ||..|...|||||..||..::          :||::.| .||.:::: ||.||:   |::
Mouse   514 WENIFCSRVEMTRRKEMTSLR----------AFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKE 568

  Fly   340 --LNAEKAFFVTAYYNILRRSVTMFF--PQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNA 400
              .:...||...:.::||   ||..|  ...:....:.||||::|..|:...|  :|:    :..
Mouse   569 SDFSPSVAFASLSLFHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAE--IRE----EQC 624

  Fly   401 NQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSL----------------------------- 436
            ..:..:|.|.:.|...:|..::...: .||.|...|
Mouse   625 APREPAPQGQAGKYQAVPLKVVNRKR-PAREEVRDLLGPLQRLTPSMDGDADNFCVQIIGGFFTW 688

  Fly   437 ----EPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTL---------------- 481
                .|||.:|.:::.|.:|..::|.||.|||||:.|.|||:...||.:
Mouse   689 TPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPRY 753

  Fly   482 -----------------RINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDF 529
                             |..|..:||:|:|||...||.:||.|...::|.||:.|::.|:|:.|.
Mouse   754 CLRTSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDI 818

  Fly   530 ELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYL 594
            ::||.||:|.:||||.:|||||:.|||:|||:|:..::..||||.||:|.|:..||....:...|
Mouse   819 DILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELL 883

  Fly   595 RSE--LVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLD-FAQLLTAPNKDAEDLDEI 656
            |.:  .|:||||:||:|..||.|:.|..|.|...||....:||... |....|..|:..::|::
Mouse   884 RDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEK- 947

  Fly   657 DGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQE-------TRVEG 714
                        ...:.|:..:.|:...|..|......:.|...:|.:.:.:|       .....
Mouse   948 ------------ETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDDNLSSVLHQRA 1000

  Fly   715 KIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVD---------KNVDGQTDIN 770
            ||......:||:| :...::..:||..|...::..|.||:|:.|.|         :|.....:..
Mouse  1001 KIPWRACTKYLSS-AGVLLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECA 1064

  Fly   771 TDPQDMY--YFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRIL 833
            .| |.:|  .|..|....:...:|.::......::.:.:||.::...|..|.|.||.|.|.|.||
Mouse  1065 LD-QSVYAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSIL 1128

  Fly   834 NRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSR 898
            ||||.|...:|:.:||.:..:.:..|..:..:.||....|.:|:..|.||::.|:|::::...||
Mouse  1129 NRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASR 1193

  Fly   899 DVKRLEAVARSPIYSHLSATITGLPTIRALGAQ---KELIAEFDNLQDLHSSGYYTFL-ATNRAF 959
            |:::|:...:.|:.||.:.|:.||.||||...:   ::.:.|:.:..::.|    .|| |.||..
Mouse  1194 DLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIAS----LFLTAANRWL 1254

  Fly   960 GY------------YLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAE 1012
            ..            |:.....|......::..::...|.|.|||.:|.|:.::..:.|.:|..|:
Mouse  1255 EVRMPGPAAVLPQEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLAD 1319

  Fly  1013 LENTMTAVERVVEYDEIEPEGEFDSREG-KKPS---PSWPEKGEIIAEDLCLRYFPDPQAKYVLK 1073
            :|..:.||:|:  :..::.|.|  |.|| ..||   .:||::|:|..::|.:||  |...|.|||
Mouse  1320 MEIQLGAVKRI--HTLLKTEAE--SYEGLLAPSLIPKNWPDQGKIQIQNLSVRY--DSSLKPVLK 1378

  Fly  1074 ALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQE 1137
            .:|..|.|.:|:||.||||:||||...|.||: ...||.|.||..|.|.:.|..|||::|||.|:
Mouse  1379 HVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQD 1443

  Fly  1138 PVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLA 1202
            ||||||::|:||||.::.:|:.||:|||..:||.::..||.||.:.|:|||.|||.|||||.|||
Mouse  1444 PVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLA 1508

  Fly  1203 RAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLV 1267
            ||.:|:..:.:||||||::|..|:.::|..:.:.|.|.||:|||||::||:.:|.|:|:..|.::
Mouse  1509 RAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAIL 1573

  Fly  1268 EFGSPYELLTSSESKIFHGMV 1288
            ||..|.:||:..:| :|...|
Mouse  1574 EFDKPEKLLSQKDS-VFASFV 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	437/1437 (30%)
		ABC_membrane	93..359	CDD:294371	76/300 (25%)
		ABCC_MRP_domain1	422..622	CDD:213217	89/267 (33%)
		ABC_membrane	735..978	CDD:294371	69/269 (26%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	109/221 (49%)
Abcc8	XP_036008753.1	MRP_assoc_pro	224..1594	CDD:188098	433/1426 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650