Protein Alignment Mrp4 and mrp-8

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_499598.2
• Gene: mrp-8 / 190710
• WormBaseID: WBGene00003414
• Length: 1461
• Species: Caenorhabditis elegans
• Alignment Length: 1345
• Identity: 435/1345 - (32%)
• Similarity: 701/1345 - (52%)
• Gaps: 139/1345 - (10%)

  Fly     8 ELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVA-- 70
            ::.:.|.|:||.||.:.||:..|::..|.|:.|..:.|:...:...|:.|..|..|.:|::.|
 Worm   172 KIEQTPEEKSSFLSKIFFCWLNPLIRAGAKQPLTNESLHNLNENATSEWLYTRWRAEFDKEKAGR 236

  Fly    71 -KNETP------RLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKA 128
             ..||.      |:.||..      :.:|...|.|.  :.....||.|..::.|.:.:|...|..
 Worm   237 KSGETSIVWPFIRIQRATI------ITLTLARLTAD--IVHYLNPILLKQLIDYVSLHDQPLSFG 293

  Fly   129 QLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLS 193
            ...|..:.:.|.....:.:..:.|:....:..:..||:.|..|.||||.:|..:.|.|:::|..:
 Worm   294 IAIACIMFSCSTTRSLLQNYQIAGMCRQAVYYQTVLSNAILHKILRLSPSARSNRTAGEILNHAA 358

  Fly   194 NDVGRFDLVLINVHYL---WIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVL 255
            .|:   ::::.:|.||   |..|.::.....::.:.:|.::|.||.||:||:|......:...:.
 Worm   359 VDI---EIIVHSVPYLQNMWSVPFQVTLAMTMLAITLGWAAMAGVCIMILFIPLNLCTSRFIKLS 420

  Fly   256 RLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMF 320
            :.:.....|||.::.||:::||:|:|:||||:.|...:...|      .|:|..:|.:.|
 Worm   421 QQKQMKIKDERTKLSNEMLNGIKVVKLYAWEESFEDQINRLR------AKEVKMLRNVCI----- 474

  Fly   321 LSRIF-----TSSSLIA------FVLLG---NILNAEKAFFVTAYYNILRRSVTMFFPQGISEFA 371
            ||||.     .|..|:|      :||..   |.|....||.....:|.||:.:.| ....|:...
 Worm   475 LSRIVDVANAASPFLVAIGSFTCYVLWSPDENGLTPSVAFVALTIFNQLRQPMRM-VANLINTLV 538

  Fly   372 ELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSL 436
            :..||.:||..|::..|.:           :|.|...|          |.|.|......|:....
 Worm   539 QARVSNKRLRQFLNDEEME-----------RKTEVALG----------NAIVFKNASLNWKGPQN 582

  Fly   437 EPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTV 501
            .|.|:|::..:...:|:|::|.||.|||||:.|:|.|:....|.:::.||.:|..|..|:|..|:
 Worm   583 PPVLKDLSATIKPGQLIAIVGSVGGGKSSLLSAVLDEMVLLDGRVKVGGSIAYVPQHSWIFNKTI 647

  Fly   502 RQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRAD 566
            ::|||||.:...:.|..||..|.|:.||.....|:.|:|||.|.:||||||||||||||||:..|
 Worm   648 KENILFGNELSNYFYDQVVGSCQLKTDFRHFQQGENTMVGENGITLSGGQKARISLARAVYQDKD 712

  Fly   567 IYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTY 629
            ||||||||||||.||||.|||:.:  .|.|||:..:||||.||:.:..|.|.:::.|:|...|::
 Worm   713 IYLLDDPLSAVDAHVGRALFDKVIGPDGLLRSKTRVLVTHNLQYTKYVDTIYVIEDGQIVQHGSF 777

  Fly   630 SSMKRSGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGS----KNSKPSTRNNSFT 690
            ..:......|.:|.:......||:.:.:....:......||.|....:    |:|:....|:.|:
 Worm   778 EDIAYVDGPFGRLWSECENSDEDVADEEAESSEASVTPPVPVLENGDNGAIEKSSQIDRTNSHFS 842

  Fly   691 SLSSMAESMAQEASLQMQETRVEGKIGLGLYKEYL-TSG---SSWFMIFFMV-FLCLATQILCSA 750
            ..|..:|...|:....::..:: |::...:|:.|: |.|   ||.|:|||:. |..:..:.|
 Worm   843 EKSRKSEEKPQKVEKNVENVQL-GRVKKSVYQLYIKTMGIFNSSAFLIFFIAHFTVMIMRSL--- 903

  Fly   751 ADYFLSYWVDKN-------------------VDGQTDINTDPQDMYYFAA--------LNVAVVV 788
               :||.|.::|                   |||...:.|   .:..:|.        |.:|..|
 Worm   904 ---WLSDWSNENAAIKKATLSSVDYLNSTSSVDGPVSVET---RLIVYAGFGGLEMLLLALAFTV 962

  Fly   789 FTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLD 853
            .||        .::|:|..||:.:...:..|.:.||:|.|:|||:||.|:||..:|::..::.:
 Worm   963 LTI--------GSLRASYGLHSPLIHALLVAPISFFDTTPTGRIINRLSRDLDVIDKLQDNIRM- 1018

  Fly   854 VVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSAT 918
            ..|..|....|:|:|.|:.|.:|:....|.:|:|::..:|:.|||.:||||:..||||.|.::.:
 Worm  1019 CTQTLLNACMILVLISISTPIFLVCAAPLILIYYFVMIYYIPTSRQLKRLESANRSPILSTIAES 1083

  Fly   919 ITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCF---CTLYIVI---IILN 977
            |.|..:|||....:..........|..:...|....:||.....|:..   |.|:..:   :...
 Worm  1084 IHGASSIRAFDKTERTTTALSTNVDKFAQCRYLSHMSNRWLATRLELLGNTCVLFASLSATLSTK 1148

  Fly   978 YFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKK 1042
            ||   ..:||..||:::.|:.:|.::...:|..:|:|:.:.:||||.||.::|||..:...:..:
 Worm  1149 YF---GLTPGMAGLSVSYALTITEVLNICVRSVSEIESNIVSVERVNEYQKLEPEAPWRIEKSLE 1210

  Fly  1043 PSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSY 1107
            ....||.||:|..:...:||  ......|||.::.:|...|::|::||||:|||||..||:|:..
 Worm  1211 NEEKWPVKGKIELDGFSMRY--RKNLPLVLKNIDLKIEGGERIGVIGRTGSGKSSLTMALYRMIE 1273

  Fly  1108 NE-GIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKP 1171
            .| |.|.||:.:...:||..||||:.|||||||:|||::|:|||||.:|:|.::|:.||..:||.
 Worm  1274 GESGTIKIDDVEIDTIGLHQLRSKLIIIPQEPVVFSGTLRFNLDPFNQYSDDQIWNCLEICQLKQ 1338

  Fly  1172 LISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSK 1236
            ...|....|...|:|||.|.|||:|||:||.||:||..|::::|||||:||..||.::|..||..
 Worm  1339 FAQEDDKTLDRYIAEGGKNMSVGERQLLCLCRALLRGARIVILDEATASVDTVTDGIVQRAIRQH 1403

  Fly  1237 FRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSES 1281
            |...|.::|||||:||:||||::|:|||.:.||.:|..||.:.:|
 Worm  1404 FPQSTTISIAHRLDTIVDSDRIVVLDAGRVAEFDTPSNLLLNPDS 1448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	435/1340 (32%)
mrp-8	NP_499598.2	MRP_assoc_pro	177..1451	CDD:188098	435/1340 (32%)