DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and mrp-3

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_001359552.1	Gene:	mrp-3 / 181677	WormBaseID:	WBGene00003409	Length:	1505	Species:	Caenorhabditis elegans

Alignment Length:	1358	Identity:	436/1358 - (32%)
Similarity:	724/1358 - (53%)	Gaps:	121/1358 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSMKADELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAW- 65
            |::|.      |.|.::.:|..:..:...::..|.::||...|::....:...:.|..|....|
Worm   189 QNLKC------PEENANFISRQLLLWFTQIISLGYERTLVADDVFEMDSQMDQEYLKARWKTEWL 247

  Fly    66 -------DEQVA---KNETPRLGRALTKVFG-FHLF----------------------------- 90
                   ::||.   |.|..|.|.....:.| |:.:
Worm   248 KQTEKAREKQVKLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSVIVTLWQIMKWEI 312

  Fly    91 ITGVFLLAQEFLTKVTQPICLIGVMAYF-AGNDPDRSKAQLWAAGL-IAGSVFSVCIGHPYMLGL 153
            :.|.|:.....|.:...|..|..::.:. ..|.|..:...| |.|| :||.:.|:.: :.|.:.:
Worm   313 LGGSFIKFLSDLLQFANPTFLNYLILFIETPNAPLINGIGL-AVGLFLAGQIKSLFM-NTYFIAM 375

  Fly   154 LHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIA 218
            ..:|.|::..||..:|.|:|.||.||..:.|||::||:||.||.||.::...:...|.:|.::|.
Worm   376 TRVGAKIQTMLSCAVYEKSLLLSNTARRERTVGEMVNILSIDVDRFRMITPQIQQYWSSPFQIII 440

  Fly   219 VTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMY 283
            ...|:...||::...|:.:|:..:|....:...|...:||.....|||:|::||:::||:|:|:.
Worm   441 CMVLLSQTIGVAVWAGIVVMISIVPINICVSMITKRWQLRLMKYKDERIRLINEVLNGIKVVKLS 505

  Fly   284 AWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFL---SRIFTS-SSLIAFVLLG--NILNA 342
            |||....:.:|..|..|:..|||    ..:|.:||..|   :.:|.: ||...|||:.  |:|..
Worm   506 AWETAMEETIERVRDKELKMIKQ----SALLKTFADCLNVGAPVFVALSSFTVFVLIDPKNVLTP 566

  Fly   343 EKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESP 407
            ..||...:.:|:||..: |...:.:::..:|:||.:|:..|:...|.   |.:.:
Worm   567 NIAFVSLSLFNLLRGPL-MMAAELVAQTVQLVVSNKRVRTFLCEKEV---DTAAI---------- 617

  Fly   408 NGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILG 472
              |......:..|.:|.......|:|.... .|.||....|.::||.|:|.||:|||||:.|.||
Worm   618 --DKEIRGELYTNTVEIHSGSFAWDSAEAR-ILSDIEFLAGSKELVTVVGSVGSGKSSLLLAALG 679

  Fly   473 ELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDK 537
            |:....|.:.:.||.:|.:|:||:...::::|:|...|.:...|:.|::.|||:.|.:.||.||.
Worm   680 EMEKVCGYVGVRGSVAYLSQQPWILNQSLKKNVLMQADLNDVLYKKVIESCALKEDLKQLPDGDD 744

  Fly   538 TIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSELVI 600
            |.:||:|.:|||||||||:||||||:..|:|.|||||||||.|||:|:||..:  .|.|.....|
Worm   745 TEIGEKGINLSGGQKARIALARAVYQSKDVYFLDDPLSAVDAHVGKHIFDNVIGPNGMLSHTTRI 809

  Fly   601 LVTHQLQFLEQADLIVIMDKGRISAMGTYSSM-----KRSGL-----DFAQLLTAPNKDA---ED 652
            |||:...||:::..|::|..|||...|||:.:     .|..|     ::||...:..:::   |:
Worm   810 LVTNCTSFLQESGKIIVMKDGRIKHCGTYNELLTDVEAREYLQEVDNEYAQAQESSGEESGGEEN 874

  Fly   653 LDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKIG 717
            .|.:.|:...|..:..:..||:...|.||           ||:.|....:|.:..:|..: |::.
Worm   875 SDILPGSIASGSRMSRLSRLSKISRKKSK-----------SSIVEKKKPDALITKEEAAI-GRVN 927

  Fly   718 LGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAA---DYFLSYWVDKNVD-GQTDINTDPQDMYY 778
            .|:|..|.   .:..::.:::...:|..:..|.|   ..:|:.|.|.|:| ...|..:....:..
Worm   928 PGVYLLYF---KAMGIVTYVLPYAIAVVLNVSFALGRSLWLTAWSDANIDINHPDTMSVGARLGV 989

  Fly   779 FAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQL 843
            :|...:..|:|.....:|.....:.:|..||..:...:.|..:.:|:..|.|||:||.:||:..:
Worm   990 YAGFGITEVIFLFFSLVLLLIGGVAASKNLHKPLLHNVLRNPLSYFDITPIGRIINRLAKDMEVV 1054

  Fly   844 DEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVAR 908
            |..|.|....:|...:.::..::::..|.|.::.:.:.:.||::::.::.:|::|.::|:.::.|
Worm  1055 DLRLSSSFRFLVMALINMVQTVLIVSYTTPLFIAIIIPVFIIYFFVLKYSIKSTRQLQRIASLTR 1119

  Fly   909 SPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLH-SSGYYTFLATNRAFGYYLDCFCTLYIV 972
            |||:|:.|.|:.|:.|:||.....|.:...|...:.| ...||:.:| ||.....|:....:.|.
Worm  1120 SPIFSNFSETLQGISTVRAFQWSDEFVRRNDEHLNTHVKCSYYSQMA-NRWLSIRLELLGNIVIF 1183

  Fly   973 IIILNYFINPPQ--SPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEF 1035
            ...:...|....  :.|.:||:::.::.:|.|:...:||..|:|..:.:|||:.||.:.:.|.|:
Worm  1184 SAAILAIIGKESGITAGMLGLSVSYSLNITFMLNMFVRQINEVETNVVSVERIDEYSKTKSEAEW 1248

  Fly  1036 DSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLIN 1100
            .......|| :||..|.:..||...||  ..:...|||.::..|.|.:|||:.||||||||||..
Worm  1249 RLDNNNLPS-NWPTGGAVNIEDYSCRY--RDELDLVLKQISLNILPGQKVGVCGRTGAGKSSLAL 1310

  Fly  1101 ALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDAL 1164
            ||||: ...:|.|:||:..|:.:||.|||.|::|||||.|||:.::|:|:||..::.|.:||.||
Worm  1311 ALFRIVEAADGNISIDQTITSHIGLHDLREKLTIIPQENVLFANTLRFNIDPKGQFTDQQLWLAL 1375

  Fly  1165 EEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALI 1229
            |...||..:..||:.|:|.::|||.|||||||||:||.||:||:::|||:|||||.:|.:||.::
Worm  1376 ENSNLKAHVELLPHKLESPVAEGGENFSVGQRQLLCLTRALLRKSKVLVLDEATAGIDNRTDTMV 1440

  Fly  1230 QATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGM 1287
            |||||.||.|.|::||||||:||:|.||::|||||.:||.|.|.|||.:..|: |:|:
Worm  1441 QATIREKFADSTIITIAHRLHTIIDYDRIIVMDAGRIVEDGIPGELLKNRNSQ-FYGL 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	430/1336 (32%)
		ABC_membrane	93..359	CDD:294371	85/273 (31%)
		ABCC_MRP_domain1	422..622	CDD:213217	88/201 (44%)
		ABC_membrane	735..978	CDD:294371	58/247 (23%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	119/221 (54%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	436/1358 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5384
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720