Protein Alignment Mrp4 and pgp-14

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_510128.1
• Gene: pgp-14 / 181416
• WormBaseID: WBGene00004008
• Length: 1327
• Species: Caenorhabditis elegans
• Alignment Length: 1448
• Identity: 331/1448 - (22%)
• Similarity: 580/1448 - (40%)
• Gaps: 325/1448 - (22%)

  Fly    10 PEN--------PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSD-SLGDRLCAAW 65
            |:|        |.:||:.|       |:|.|               |:.:.||| .:...|.|.:
 Worm     7 PDNRGFDDQRRPSQRSTVL-------AIPAL---------------AVNDPKSDPKIASDLPANY 49

  Fly    66 ---DEQVAKNETPRLGRALTKVFGFHL---------------FITGVFLLAQEF----------- 101
               |:...|..||.|   |.|:..:.|               .|.|:|...::|
 Worm    50 VDDDDDAPKMYTPSL---LEKILNYALCRGDIANQQLEAQPVSIPGLFRYGKKFDYLLLFIGTIC 111

  Fly   102 --LTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFSVCIGHP--------------YM 150
              ::.|:|||                       ..|::|.|.:..:.:|              |
 Worm   112 AIISGVSQPI-----------------------LALVSGRVTNALLVYPPTSKQFRNKANENVY- 152

  Fly   151 LGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQ-----VVNLLSNDVGRFDL--------- 201
               :.||:.:.|::::.|.....:...|.:    :.|     |.::|..:.|.||.
 Worm   153 ---IFLGIGIFISITNFIQYMCFQHCCTRV----MAQMRHRFVYSVLRQNAGWFDKNHSGTITTK 210

  Fly   202 -----------------VLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVA----IMLLFLPFQ 245
                             ||:....:.||   .|.|.|:....:. |.|.|||    |.:..|..|
 Worm   211 LNDSMERIREGIGDKLGVLLRGFAMLIA---AIVVAYIYEWRLA-SMMLGVAPTCCICMSLLARQ 271

  Fly   246 SY---------LGK-----RTSVLRLRTALRTDERVRMMNEIISGIQVIKMYA-----WEKPFGK 291
            ..         :||     ..|::.:||....:.:..|:....:.::..:.:|     |...||.
 Worm   272 MTSTTIKELIGVGKAGSIAEESLMGVRTVQAFNGQEEMVGRYEAELEKGRKFAVWKGFWSGFFGG 336

  Fly   292 VVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILR 356
            :.....|:.:.|        |:|....:....|.|:...:..|::..:|.|
 Worm   337 LFFFWLFSFLGC--------GMLYGAYLLKVGIITTPGDVFIVVMSMLLGA-------------- 379

  Fly   357 RSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENL 421
                 :|...||....:|::.|...|.:::...:|........|.::.::..|           .
 Worm   380 -----YFLGLISPHMMVLLNARVSAASIYQTIDRVPKIDPYSKAGKRLQNVVG-----------R 428

  Fly   422 IEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRING- 485
            ::|.....|:.|......|..:||.:.....||::|..|.|||:.:..:......|:|.:.|:|
 Worm   429 VKFENVHFRYPSRKDAKILNGLNLVVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEAGNVTIDGT 493

  Fly   486 ------------SYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDF-ELLPFGDK 537
                        :.....|||.||..|:..|:|.|...........|.|.|...|| |.:|.|..
 Worm   494 DVRELNIEWLRNTVGIVQQEPILFNDTIHNNLLIGNPGSTRETMIEVCKMANAHDFIEKMPKGYD 558

  Fly   538 TIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILV 602
            |::|:.|..||||||.|:::||.:.|...:.|||:..||:|.. ...:....:....:....|::
 Worm   559 TLIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQ-SESIVQSALNNASKGRTTIMI 622

  Fly   603 THQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAP--NKDAEDLDEIDGAGGDGLD 665
            .|:|..:.:||.||..:||.|...|.:..:.|.|..:..|:.|.  ..|.|..:|.:   .:.:|
 Worm   623 AHRLSTIREADKIVFFEKGVIVEAGNHEELVRLGGRYFDLVKAQQFKADPEATEEFE---EEEID 684

  Fly   666 LLNVPSLSRRGSKNS---------KPSTRNNSFTSLSSMAESMAQEASLQMQETRV---EGKIGL 718
            |.:....|||.|..|         :.::.|:||:.....|::.|:.::....|..:   :|:|..
 Worm   685 LDDTSRSSRRSSMTSARSGSEAFRRGNSLNDSFSGSKRSAQADAENSAFAANEAAIMAEDGQITA 749

  Fly   719 G---LYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQDMY--- 777
            |   ::|.  ..|:..:|....||..:....|.:.|..|  .||   .:|.|.:....:.|:
 Worm   750 GYLDIFKN--AKGNYLYMFLGTVFALIRGLELPALALIF--GWV---FEGFTFVPYGGRMMHRMA 807

  Fly   778 ----YFAALNVAV--------VVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFN-TNPS 829
                .||::.|.|        |:|.:|...|..:..::|   ..|.:||.    |.||.| .:..
 Worm   808 MAVIAFASVGVGVWFSQLASSVLFAVVSENLSMRFRVQS---FRNLLYQD----ASYFDNPAHAP 865

  Fly   830 GRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPY-----YLILTLALAIIFYYI 889
            |:::.|.:.|...:..|:.:.||.|:   ..|..||..|.|...|     .|..:|.|.:.|..|
 Worm   866 GKLITRLASDAPNIKAVVDARMLQVI---YALAAIIANIAIAFIYCWQIGILGTSLILLLAFVMI 927

  Fly   890 REFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQD----------- 943
            ...|..:..:|::::......|...:   |..:.||:.| .:.||.  ||:.|.
 Worm   928 GLAYKISLMNVEQIQNDDAGRIAIEI---IENVKTIQLL-TRCELF--FDHYQTSSKQQKRSELK 986

  Fly   944 ---LHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQW 1005
               :.:..|    :..::|.|::.||  .|.|.|.:.|..:........|: |...:|...::..
 Worm   987 KGMIEAINY----SLTQSFMYFMMCF--TYAVGIRIIYQGDKSSDDTFKGI-IAMMLGAVAVMNS 1044

  Fly  1006 AMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKY 1070
            | :...|.....||...:......:|. ..|..||.:|.    .:|.|:.|::...| |....:.
 Worm  1045 A-QYFPEFVKAKTAAGMLFNIIYRKPR-TGDLMEGDRPE----IRGNILFENVKFSY-PQRPLQP 1102

  Fly  1071 VLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISII 1134
            ::|.|.:.....:.|.:||.:|:|||:.|..|.|. ....|.:.||.:|...:.||.||::::::
 Worm  1103 IMKGLQWTALRGQTVALVGPSGSGKSTNIGMLERFYDVTGGALRIDGQDIRKLSLFHLRTQMALV 1167

  Fly  1135 PQEPVLFSGSMRYNL------DPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSV 1193
            .|||.||:|::|.|:      .|.|:.|     .|||.......::.||.|:.:.:.|.|...|.
 Worm  1168 GQEPRLFAGTIRENVCLGLKDVPLEKIN-----QALELANANRFLANLPAGIDTDVGEKGGQLSG 1227

  Fly  1194 GQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRV 1258
            ||:|.:.:|||::|:.::|::||||:.:|.:::..:|..:.......|.:||||||::|.:||.:
 Worm  1228 GQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSSIQNSDLI 1292

  Fly  1259 LVMDAGHLVEFGSPYELL 1276
            :.:|.|.:.|.|:..:|:
 Worm  1293 VYIDKGKVQEAGNHTQLM 1310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	330/1446 (23%)
		ABC_membrane	93..359	CDD:294371	57/346 (16%)
		ABCC_MRP_domain1	422..622	CDD:213217	61/213 (29%)
		ABC_membrane	735..978	CDD:294371	64/277 (23%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	73/227 (32%)
pgp-14	NP_510128.1	PTZ00265	104..1321	CDD:240339	304/1326 (23%)
		ABC_membrane	109..377	CDD:279056	52/310 (17%)
		ABC_MTABC3_MDL1_MDL2	429..666	CDD:213216	67/237 (28%)
		ABC_membrane	769..1039	CDD:294371	68/297 (23%)
		ABC_MTABC3_MDL1_MDL2	1086..1323	CDD:213216	73/231 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000