DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mrp4 and pgp-8

DIOPT Version :9

Sequence 1:NP_650086.2 Gene:Mrp4 / 41387 FlyBaseID:FBgn0263316 Length:1316 Species:Drosophila melanogaster
Sequence 2:NP_509811.2 Gene:pgp-8 / 181277 WormBaseID:WBGene00004002 Length:1243 Species:Caenorhabditis elegans


Alignment Length:1316 Identity:298/1316 - (22%)
Similarity:564/1316 - (42%) Gaps:255/1316 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 LFITGVFL-----LAQEFLT----KVTQPICLIGVMAYFAGNDP-DRSKA-QLWAAGLIAGSVFS 142
            ||:.||..     |.|.|::    :|:|....|......|..|| |..|| :::.|.:....:..
 Worm    39 LFVIGVVSAICTGLTQPFMSYTFGEVSQAFVRITAAVNNASLDPSDLEKAYEMFHADMNNVVIHF 103

  Fly   143 VCIGHPYM-LGLLHLGMKMRIALSS---LIYRKALRLSR--TALGDT-TVGQVVNLLSNDVGRF- 199
            ..:|..:| .|.:...:...|..::   |.::..|||.:  ....|| :.|.:..:|::::.|| 
 Worm   104 GLVGCAFMFFGFIQFSLFKYIGDNTTYRLRHKFILRLLKKDAKYFDTISTGYLSTVLNDNLERFR 168

  Fly   200 ----DLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTA 260
                :.:...:.:.....:......|..:......|:|...|::            :.:|...:.
 Worm   169 EAFNEKIAFIICFSTDFAIGTALAFYTSWTLASYGSVFAFGIVI------------SGLLNSTSM 221

  Fly   261 LRTDERVRMMNEIISGIQVIKMYAWEKPF---GKVVEMTRFN-EMLCIKQVNYIRGILISFAMFL 321
            ::::|:..|.......|....:.:::...   |:..|:.::: |:...::....|...::.:..|
 Worm   222 MKSNEKQSMHYSNAGAIAFQALCSFKTVISLNGQTQELEKYSAELKEGEKFGSRRAFFLATSRGL 286

  Fly   322 SRIFTSSSLIAFVLLGNILNAEKAFFVTA--YYNILRRSVTMFFPQGISEFAELLVSVRRL-EAF 383
            |..|.::      |.|.||      :|.|  .||....:|.:     ::.|..:|.|...| |||
 Worm   287 SHFFCNA------LNGTIL------YVGADLIYNKTMNTVAI-----VTLFHYMLFSAFSLGEAF 334

  Fly   384 MH-----------RP--ETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHS 435
            :|           .|  :....|...::| ||..|..:     .|...:.::.|:..:..:.|..
 Worm   335 LHISYLLNAINSATPIFDVLTSDDDMIEN-NQDNEQTD-----SNKTIQGMLSFNNVKFAYPSRP 393

  Fly   436 LEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSY----------- 489
            ....|..|:..:.:.:.:|::|..|:|||:::|.:|.....:|||::|..|:.:           
 Worm   394 DVDILRGISFDVKQGECIALVGASGSGKSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQLRNAI 458

  Fly   490 --AAQEPWLFTGTVRQNILFGLD--WDKHRYRTVVKKCALERDFEL-LPFGDKTIVGERGASLSG 549
              .:|||.||..|:.:||.||..  .....|..:.|..|.  ||.. :..|.|||||||||.|||
 Worm   459 GVVSQEPVLFNTTIEENIRFGNPNATSSEIYEALRKANAY--DFVCNIKDGLKTIVGERGAQLSG 521

  Fly   550 GQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADL 614
            |||.||::||.:.:...|.|||:..||:|: .........::........|::.|:|..:...|.
 Worm   522 GQKQRIAIARVLVKNPAILLLDEATSALDS-ASERAVQLALKKASEGRTTIIIAHRLSTIRHCDK 585

  Fly   615 IVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDLDE-IDGAGGDGLDLLNVPSLSRRGSK 678
            |::|..|:|:.:|::..:.....:::.|:.|...|::.::| |:|.|.:.:.....|:|: .|..
 Worm   586 IMVMSNGKIAEVGSHEELISMDREYSNLVRAQFFDSQSVEEDINGQGAEEVIQKTPPNLN-DGEP 649

  Fly   679 NSKPSTRNNSFTSLSSMAESMAQEA-------SLQMQETRVEG-------KIGLGLYKEY----- 724
            ..:.....:|...:.|....:.:|.       |:.:..:.::|       :|.:..||.|     
 Worm   650 LEELLKETSSDIEIKSNIWEVLRECRPDAFLLSMAVIGSAIQGCNFPILSQIIVQTYKAYAMDGE 714

  Fly   725 --LTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQDMYYFAALNVAVV 787
              ||.|..|..:|.::.:.....:.|                           .::|        
 Worm   715 NILTYGHFWAAMFLVLGVIRPITLYC---------------------------QFFF-------- 744

  Fly   788 VFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNT---NPSGRILNRFSKDLGQL----DE 845
                     |.|::.:.||:|....:|.:......|::.   :|: |::||.:.|...:    |.
 Worm   745 ---------FGKVSEKLSTRLRIKSFQHLLSLPCAFYDDPKHSPT-RLVNRLNTDPSNIKAAVDA 799

  Fly   846 VLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIF---YYIREFYLKTSRDVKRLEAVA 907
            .|.|:::.:|...|.:|    :.|.   |...|||.:.:.|   ||.:..|.||:....:.::||
 Worm   800 RLGSLLMSMVSFSLAIL----IACY---YSWKLTLQVVLFFPVLYYAKFLYKKTTTISIKEDSVA 857

  Fly   908 RSPIYSHLSATITGLPTIRALGAQK---ELIAEF--------------DNLQDLHSSGYYTFL-A 954
            ...........:..:.|::||..:.   .|:.|:              ..|.:..|:|....: |
 Worm   858 FENSNKIAIEVLDNMKTVKALNMEARVINLVMEYLAVLKTSYPRRSVVMGLANGFSAGCSQIVYA 922

  Fly   955 TNRAFGYYL---------DCFCTLYIVIIILNYFINPPQSPGEVGLAIT------QAMGMTGMVQ 1004
            .:..||.||         |    :|:.:|.|:|..|      ..|.||:      :|:...|:: 
 Worm   923 ISFKFGTYLILQKEVIPMD----MYLSLITLSYTSN------MAGSAISYMPDFRKAIHSAGLI- 976

  Fly  1005 WAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAK 1069
                     .|..|       |....|   |:|..|.:..    .|||:..|::...|...|...
 Worm   977 ---------FNLFT-------YPATMP---FNSDTGSRSI----TKGEVNGENVKFHYHQRPDYT 1018

  Fly  1070 YVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSY--NEGIITIDERDTADMGLFDLRSKIS 1132
             ||.::|.::...:.:.|||.:|:|||::| :|..:.|  ::|.|.||..:..::.|..|||.:.
 Worm  1019 -VLDSVNLKVEAGKTLAIVGPSGSGKSTII-SLLEMFYRADQGFIKIDNDNVENINLDHLRSNLG 1081

  Fly  1133 IIPQEPVLFSGSMRYNL--DPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQ 1195
            ::.|.||||:.|:|.|:  ......:..::.:||:.......:.:||.||.:.:.:.|:..|.||
 Worm  1082 LVSQGPVLFNCSIRDNILYGLTRNISQTEIENALQIANAFNFVFQLPQGLDTIVGDRGAQLSGGQ 1146

  Fly  1196 RQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLV 1260
            :|.:.:.|||||..::|::||||:.:|.:::.::|..:.:.....:.:.:||||:||:::|.:.|
 Worm  1147 KQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALDTASERLSTIVVAHRLSTIINADSIAV 1211

  Fly  1261 MDAGHLVEFGSPYELL 1276
            :..|.:||.|:..:||
 Worm  1212 LRNGKVVEQGTHNQLL 1227

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mrp4NP_650086.2 CFTR_protein 12..1277 CDD:273530 298/1316 (23%)
ABC_membrane 93..359 CDD:294371 52/294 (18%)
ABCC_MRP_domain1 422..622 CDD:213217 65/215 (30%)
ABC_membrane 735..978 CDD:294371 51/279 (18%)
ABCC_MRP_domain2 1051..1272 CDD:213211 69/224 (31%)
pgp-8NP_509811.2 PTZ00265 29..1241 CDD:240339 298/1316 (23%)
ABC_membrane 44..326 CDD:294371 54/310 (17%)
ABC_MTABC3_MDL1_MDL2 382..617 CDD:213216 69/237 (29%)
ABC_membrane 685..953 CDD:279056 61/323 (19%)
ABC_MTABC3_MDL1_MDL2 1005..1240 CDD:213216 69/225 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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