Protein Alignment Mrp4 and mrp-4

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_509658.1
• Gene: mrp-4 / 181202
• WormBaseID: WBGene00003410
• Length: 1573
• Species: Caenorhabditis elegans
• Alignment Length: 1416
• Identity: 484/1416 - (34%)
• Similarity: 750/1416 - (52%)
• Gaps: 173/1416 - (12%)

  Fly     6 ADELPE-----------NPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGD 59
            ||..||           :|...||.|:.:...:...:...|.||.||..|||...:...|:.|..
 Worm   200 ADASPEGYKYLSAARNPSPETTSSFLNRITMWWFNSLCSLGVKKPLEVSDLYSLNEADTSNLLVP 264

  Fly    60 RLCAAWDEQVAKNE-------------------------TPRLGRALTKVFG------------- 86
            :....||:|..|.|                         ||.|....|..:|
 Worm   265 KWYNLWDKQSKKFEETAARRRIGSNASRTNRRRTSSNDTTPLLNDQSTDDYGSVPAGQSTQKMPS 329

  Fly    87 -----FHLF----ITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVF- 141
                 |.:|    ||.:|:.....:.....|:.|..::.:     .:..:..:|...::|.::|
 Worm   330 IIWTLFLMFKWDVITAMFVKLLSDVLLFCNPLLLKSLIRF-----TEELERPMWQGVVLAFTMFF 389

  Fly   142 -----SVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDL 201
                 |:.:.|.:.| :..:|.:::..|::.:|||.||||..|..:.|||::|||::.||.||..
 Worm   390 SAELSSILLSHYFYL-MYRVGTRVQTCLTAAVYRKTLRLSNAARREKTVGEIVNLMAIDVDRFQQ 453

  Fly   202 VLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLR---LRTALRT 263
            :.......|..|.::....:|::.::|:|...|||:|:|..|....:   |.::|   :......
 Worm   454 ITPQTMQYWSNPFQIGLALFLLFQQLGVSVFSGVAVMVLLFPINFVI---TMIIRKWQIAQMYYK 515

  Fly   264 DERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIR---GILISFAMFLSRIF 325
            |||.:|:||:::||:|||:||||.|..:|:|..|..|:..||:..::|   .:|.:.:.||..:.
 Worm   516 DERTKMVNEVLNGIKVIKLYAWEPPMEQVIEDLREQELGLIKKAAFLRTFSDMLNTASPFLVALS 580

  Fly   326 TSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETK 390
            |.::.| ::...|:|..|.||.....:|.||..::. ..:.|::..:::||.|||:.|:
 Worm   581 TFATFI-YIDPKNVLTPEIAFVSLTLFNQLRSPMSQ-VAELITQTVQVVVSNRRLKEFL------ 637

  Fly   391 VRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWES--HSLEPTLEDINLQLGRRKLV 453
            |.::..|:..:.:|...|           ::|...:....|||  |...|||.:|:..:.|.:||
 Worm   638 VSEELNVEAIDHRARDNN-----------DVICLKEACLSWESAEHQPVPTLTNISFSVNRGQLV 691

  Fly   454 AVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRT 518
            .::|.|||||||::||::||:...||::.::|...|..|:||:...|:||||.||..:|::.|..
 Worm   692 TIVGRVGAGKSSMLQALMGEMEKLSGSISMHGRLCYVPQQPWMQNNTLRQNITFGKQFDEYFYSR 756

  Fly   519 VVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGR 583
            |:..|||.||.::||.||.|.:||:|.:||||||||||||||||:..||||||||:||||.|||.
 Worm   757 VLDACALYRDLQILPLGDNTEIGEKGINLSGGQKARISLARAVYQNHDIYLLDDPMSAVDAHVGS 821

  Fly   584 HLFDQCM--RGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAP 646
            .||...:  .|.||::..||||::|.|||::|||::|::|:|...|.|..:.:.|. |.|||...
 Worm   822 QLFGSVIGPEGMLRNKTRILVTNELSFLEKSDLIIVMNEGKIEYSGKYDDLMQQGA-FEQLLIEC 885

  Fly   647 NKDAEDLDEIDGA---------------GGDG-----LDLLNVPSLS-----------------R 674
            .|:..:..|.:.:               |||.     .|::..|.:.                 |
 Worm   886 EKEERERREAEASADEDDENSEPGGIMIGGDSDFEYDDDVMASPIIDHVLGTSHMSTVSGIINRR 950

  Fly   675 RGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQET-RVE-GKIGLGLYKEYLTSGSSWFMIFFM 737
            |.|.::....|..|.|...:.:.:.|...:.|:..| ||| |::.:..|.:|..:......:.|:
 Worm   951 RISTSTHKQRRRLSTTKSHTHSITSASTQTRQLTGTERVETGRVKMDTYYKYFGAMGMSIAVLFV 1015

  Fly   738 VFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQD----MYYFAALNVAVVVFTIVRTMLFY 798
            :.:..:| |.....:.:|:.|.:.|. .::..||..|.    :..:|.|..:.::...:..:...
 Worm  1016 LGMTTST-IFSMGRNLWLTDWSNDNA-ARSGSNTTGQPIAIRLGVYAGLGFSEIILLFIGMLSLL 1078

  Fly   799 KMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLG 863
            ...:.:|..||..:.:.:.|..|.|::|.|.||||||..||:..:|.:||..:....|..|.::.
 Worm  1079 YGGVSASRNLHAPLMRNLFRVPMAFYDTTPFGRILNRIGKDIETVDVLLPFNVQFFAQCLLQVVS 1143

  Fly   864 IIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRAL 928
            .:::|.|:.|.:.|:.:.|::::..:..:|:.|||.:||||::.|||||||||.:|.|..||||.
 Worm  1144 TLIIIMISTPVFGIVIIPLSVMYLMVMRYYIATSRQLKRLESITRSPIYSHLSESIQGSATIRAY 1208

  Fly   929 GAQKELIAEFDNLQ----DLHSSGYYTFLATNRAFGYYLD----C---FCTLYIVIIILNYFINP 982
                .|:..|..|.    |.|....|.....||.....|:    |   |..|:..:      ...
 Worm  1209 ----HLVDRFCKLSETKVDSHVQCRYLNYVANRWLSVRLEFIGNCIVLFSALFAAL------TRT 1263

  Fly   983 PQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSW 1047
            ..:.|.:||:::.|:.:|.::.:|:||..:||..:.:||||.||.|.|.|.|:.|..||:|..:|
 Worm  1264 TTTSGVIGLSVSYALNITTVLNFAVRQITKLETNIVSVERVKEYAETETEAEWKSEPGKEPPQNW 1328

  Fly  1048 PEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGI 1111
            |.:|.|:..:...||  .|....|:|.||..|:|.|||||||||||||||:..:||| :...||.
 Worm  1329 PSEGRIVMNNYSARY--RPGLNLVVKQLNVEIKPHEKVGIVGRTGAGKSSVTLSLFRIIEAAEGQ 1391

  Fly  1112 ITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISEL 1176
            |.:|..:.|::||.||||.::||||:||||||::|:|||||..|:|..:|..||...||...:..
 Worm  1392 IVVDGINLAEIGLHDLRSNLTIIPQDPVLFSGTLRFNLDPFNHYSDGDIWKTLEMANLKEFATAH 1456

  Fly  1177 PNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCT 1241
            ...|...|:|||.|.|||||||||||||:||:.|||::|||||.||..||||||.|||.:|.:.|
 Worm  1457 NEQLNYIITEGGDNISVGQRQLVCLARALLRKTRVLILDEATAAVDVSTDALIQKTIREEFANAT 1521

  Fly  1242 VLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETG 1292
            |||||||||||||.||::|::.|.:.||.||..||::..|: |:.|....|
 Worm  1522 VLTIAHRLNTIMDYDRIIVLNDGKVGEFDSPANLLSNRNSE-FYSMAKRAG 1571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	475/1382 (34%)
		ABC_membrane	93..359	CDD:294371	78/277 (28%)
		ABCC_MRP_domain1	422..622	CDD:213217	102/203 (50%)
		ABC_membrane	735..978	CDD:294371	72/257 (28%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	124/221 (56%)
mrp-4	NP_509658.1	MRP_assoc_pro	17..1572	CDD:188098	484/1416 (34%)
		ABC_membrane	346..613	CDD:294371	78/276 (28%)
		ABCC_MRP_domain1	658..862	CDD:213217	102/203 (50%)
		ABC_membrane	1012..1259	CDD:294371	72/252 (29%)
		ABCC_MRP_domain2	1332..1552	CDD:213211	124/221 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.730