DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and mrp-1

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_001024719.2	Gene:	mrp-1 / 180409	WormBaseID:	WBGene00003407	Length:	1534	Species:	Caenorhabditis elegans

Alignment Length:	1388	Identity:	467/1388 - (33%)
Similarity:	732/1388 - (52%)	Gaps:	157/1388 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ELPEN--------PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSL------- 57
            :.|.|        |...:|.|:.|.|.:...:.:.|.||:||::||:...:..|::::
Worm   195 DTPSNGYIGKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIEN 259

  Fly    58 ------GDRLCAAWDEQVAKN-------ETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPI 109
                  |.|      .::.||       ..|.:...:.|.:.|.|...|.:.|..:.|..|. |.
Worm   260 LIPEVEGYR------RKIKKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVA-PE 317

  Fly   110 CLIGVMAYFAG-NDPDRSKAQLWAAGLIA-----GSVFSVCIGHPYMLGLLHLGMKMRIALSSLI 168
            .|..::::... |.|      :|....||     .|:....|.|.|...:..|||.:|..|:|.:
Worm   318 LLRQLISFIEDKNQP------MWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAV 376

  Fly   169 YRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMF 233
            |.|.|.||..|....|.|.:|||:|.|:.|...:...:...|.|||:::...|.::..:|:|.:.
Worm   377 YTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLA 441

  Fly   234 GVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRF 298
            |..|::|.:||.|::..:....::......|||::||:||::|::|:|:|:|||...|:|...|.
Worm   442 GFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVRE 506

  Fly   299 NEMLCIKQVNYIR-GILISFAM--FLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVT 360
            .|:..:|:::|:. ...:|:|.  ||..:.|....:.:....|:|..:..|...|.:||||..:.
Worm   507 KEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLA 571

  Fly   361 MF---FPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLI 422
            :|   |.|.:    :...|..||:.|.                  .||..:..:....|..::.|
Worm   572 VFAMVFSQAV----QCSASNTRLKEFF------------------AAEEMSPQTSIAYGGTDSAI 614

  Fly   423 EFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSY 487
            :.......|.|...:..|.||...:.|.:|||::|.||:|||||:.|:|||:...||::::|||.
Worm   615 KMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSV 679

  Fly   488 SYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQK 552
            :|..|..|:...::|.||||...:|...|:.|::.|||.:|.|.||..|:|.:||:|.:||||||
Worm   680 AYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQK 744

  Fly   553 ARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM---RGYLRSELVILVTHQLQFLEQADL 614
            .|:|||||||:.|:|.||||||||||:|||:|:|:..:   .|.|.::..:|:||.|.:|:..|.
Worm   745 QRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQ 809

  Fly   615 IVIMDKGRISAMGTYSSMKRSGLDFAQLL---------------------TAPNKDAEDLDEIDG 658
            ::::....||.||||..:..|...|::.|                     ...|:...|||::..
Worm   810 VIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSP 874

  Fly   659 AGGDGLDLLNVPSLSRRGSKNS---KPSTRNNSFTSLSSMAESMAQEASL--------------- 705
            |....:.......:.:...||:   :.....:..|:.||:.:|..:|:.|
Worm   875 AIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQ 939

  Fly   706 ----QMQETRVE-GKIGLGLYKEYLTS-GSSWFMIFFMVFLCLATQILCSAADYFLSYWVD--KN 762
                .:::..|| ||:...:|..|..: |....::||:|:  :|:.:|...::.:|:.|.|  |.
Worm   940 TKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVY--VASSMLGVFSNLYLARWSDDAKE 1002

  Fly   763 V-------DGQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAA 820
            :       ..:|.|.     :..:|.|.:.........:::.....:.:|..||..:.:.|.|:.
Worm  1003 IALSGNGSSSETQIR-----LGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSP 1062

  Fly   821 MYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAII 885
            |.||:..|.|||||||.||:..:|..:|..|...::..::.:.||.:|....|..:.|.|.|.|:
Worm  1063 MAFFDVTPLGRILNRFGKDVDGVDTDIPRTMSMFIRTAVSSIEIIAIILWATPLAISLLLPLFIV 1127

  Fly   886 FYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYY 950
            ::.:..||:.|||.:||||:.:|||||||...:|.|..:|||.|...:.|.|..:..|.:.:.||
Worm  1128 YFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYY 1192

  Fly   951 TFLATNRAFGYYLDCFCTLYIVIIILN------YFINPP-QSPGEVGLAITQAMGMTGMVQWAMR 1008
            ..:..||.....|:....|    |:|:      ||.:.| .|.|.|||:::.|:.:|..:.||:|
Worm  1193 PSIVANRWLAVRLEMVGNL----IVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVR 1253

  Fly  1009 QSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLK 1073
            .::|||..:.||||:.||.....||  ::.:...|. ||||.|||..::..:||  .|....||.
Worm  1254 MTSELETNIVAVERINEYTITPTEG--NNSQSLAPK-SWPENGEISIKNFSVRY--RPGLDLVLH 1313

  Fly  1074 ALNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQE 1137
            .:...|.||||:|||||||||||||..|||| :..:.|.|.||..:.||:.|..|||:::|:||:
Worm  1314 GVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQD 1378

  Fly  1138 PVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLA 1202
            ||||||:||.|||||..::|.::|:||....|...:..|..||...|||||.|.|||||||:|||
Worm  1379 PVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLA 1443

  Fly  1203 RAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLV 1267
            ||:||:.:|||:|||.|.||.:||:|:|.|||.:|:|||||||||||||:|||||:||:|.|.:.
Worm  1444 RALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVA 1508

  Fly  1268 EFGSPYELLTSSESKIFHGMVME 1290
            ||.:|.:||::.:. ||:.|..:
Worm  1509 EFDTPKKLLSNPDG-IFYSMAKD 1530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	462/1369 (34%)
		ABC_membrane	93..359	CDD:294371	81/274 (30%)
		ABCC_MRP_domain1	422..622	CDD:213217	89/202 (44%)
		ABC_membrane	735..978	CDD:294371	75/257 (29%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	125/221 (57%)
mrp-1	NP_001024719.2	MRP_assoc_pro	23..1531	CDD:188098	467/1388 (34%)
		ABC_membrane	309..570	CDD:294371	79/267 (30%)
		ABCC_MRP_domain1	614..815	CDD:213217	89/200 (45%)
		ABC_membrane	976..1248	CDD:279056	84/282 (30%)
		ABCC_MRP_domain2	1293..1513	CDD:213211	125/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830