DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mrp4 and Abcc4

DIOPT Version :9

Sequence 1:NP_650086.2 Gene:Mrp4 / 41387 FlyBaseID:FBgn0263316 Length:1316 Species:Drosophila melanogaster
Sequence 2:XP_038948894.1 Gene:Abcc4 / 170924 RGDID:620266 Length:1382 Species:Rattus norvegicus


Alignment Length:1404 Identity:589/1404 - (41%)
Similarity:844/1404 - (60%) Gaps:153/1404 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 ELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQV--A 70
            |:..||.:.::..|.|.|.:..|:...|.|:.||:.|::..|.|.:|..||:.|...||::|  |
  Rat     7 EVKPNPLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKEVLRA 71

  Fly    71 KNET--PRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAA 133
            |.:.  |.|.:|:.|.:.....|.|:|.|.:| .|:|.|||.|..::.||...|.|.|.|...|.
  Rat    72 KKDARKPSLTKAIVKCYWKSYLILGIFTLIEE-TTRVVQPIFLGKIIDYFEKYDSDDSAALHTAY 135

  Fly   134 GLIAGSVFSVC------IGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLL 192
            |..|  |.|:|      :.|.|...:...||::|:|:..:|||||||||.:|:|.||.||:||||
  Rat   136 GYAA--VLSLCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLL 198

  Fly   193 SNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRL 257
            ||||.:||.|.|.:|:||..||:.|.||.|:::|||||.:.|:||:::.||.||.:||..|.||.
  Rat   199 SNDVNKFDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAGLAILVILLPLQSCIGKLFSSLRS 263

  Fly   258 RTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLS 322
            :||..||.|:|.|||:|:|:::||||||||.|..::...|..|:..|...:|:||:.::.....:
  Rat   264 KTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGSSYLRGMNMASFFIAN 328

  Fly   323 RIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRP 387
            ::....:...:|||||.:.|...|.....|..:|.:||:|||..|...:|.:|||||::.|:...
  Rat   329 KVILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVSEAVVSVRRIKNFLLLD 393

  Fly   388 ETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKL 452
            |...|          ||:.|:    .|..|    :....|.|.|:.....|||:.::......:|
  Rat   394 ELPER----------KAQEPS----DGKAI----VHVQDFTAFWDKALDTPTLQGLSFTARPGEL 440

  Fly   453 VAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYR 517
            :||:||||||||||:.|:|||||..||.:.::|..:|.:|:||:|:||||.|||||..::|.||.
  Rat   441 LAVVGPVGAGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRKYEKERYE 505

  Fly   518 TVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVG 582
            .|:|.|||::|.:||..||.|::|:|||:||||||||::||||||:.||||||||||||||..||
  Rat   506 KVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVG 570

  Fly   583 RHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPN 647
            :|||..|:...|..::.||||||||:|:.|..|:|:..|.:...|||:...:||:||..||...|
  Rat   571 KHLFQLCICQTLHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKEN 635

  Fly   648 KDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESM-----------AQ 701
            ::||...              ||         ..|:.||.:|:..|..::..           ||
  Rat   636 EEAEPSP--------------VP---------GTPTLRNRTFSEASIWSQQSSRPSLKDGVPDAQ 677

  Fly   702 EA----SLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDK- 761
            :|    :.|.:|:|.||:||...||.|.::|:|||.|.|:|.|.|..|:.....|::||:|.:: 
  Rat   678 DAENTQAAQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNLMGQVFYVLQDWWLSHWANRQ 742

  Fly   762 -----------NVDGQTDINTDPQDMYY---FAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAM 812
                       ||.|..|::      :|   :..|....|:|.|.|::|.:.:.:.:|..|||.|
  Rat   743 GALNDTKNANGNVTGTLDLS------WYLGIYTGLTAVTVLFGIARSLLVFYVLVNASQTLHNRM 801

  Fly   813 YQGITRAAMYFFNTNP------------------------------------------------- 828
            ::.|.:|.:.||:.||                                                 
  Rat   802 FESILKAPVLFFDRNPIELTQLEVFRVVDGALDSHRHLSHPHPWPQNGSLQASVTSVTGSDVIRF 866

  Fly   829 --------SGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAII 885
                    .||||||||||:|.:|::||...||.:|..|.::.:|.|.....|:.||..:.|:||
  Rat   867 PEVLLLALPGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSII 931

  Fly   886 FYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYY 950
            |..:|.::|:|||||||||:..|||::||||:::.||.||||..|::.....||..|||||..::
  Rat   932 FVVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWF 996

  Fly   951 TFLATNRAFGYYLDCFCTLYIVIIIL-NYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELE 1014
            .||.|:|.|...||..|.::::::.. :..:......|:||||::.::.:.||.||::|||||:|
  Rat   997 LFLTTSRWFAVRLDAICAVFVIVVAFGSLVLAKTLDAGQVGLALSYSLTLMGMFQWSVRQSAEVE 1061

  Fly  1015 NTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRI 1079
            |.|.:||||:||.::|.|..::.|  |:|.|.||.:|.|:.:::...|..|  ...|||.|...|
  Rat  1062 NMMISVERVIEYTDLEKEAPWECR--KRPPPGWPHEGVIVFDNVNFTYSLD--GPLVLKHLTALI 1122

  Fly  1080 RPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGS 1144
            :..|||||||||||||||||:||||||..||.|.||:..|.::||.|||.|:||||||||||:|:
  Rat  1123 KSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGT 1187

  Fly  1145 MRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILREN 1209
            ||.|||||.|::|.:||.|||||:||..|.:||..:.::::|.|||||||||||||||||||::|
  Rat  1188 MRKNLDPFNEHSDEELWKALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKN 1252

  Fly  1210 RVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYE 1274
            |:|::|||||||||:||.|||..||.||..|||||||||||||:|||:::|:|:|.|.|:..||.
  Rat  1253 RILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYV 1317

  Fly  1275 LLTSSESKIFHGMVMETGQNTFDSLLKVAEKAHLESMKP 1313
            ||.:.|| :|:.||.:.|:....:|.:.|::.:.....|
  Rat  1318 LLQNPES-LFYKMVQQLGKGEAAALTETAKQVYFRRNYP 1355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mrp4NP_650086.2 CFTR_protein 12..1277 CDD:273530 578/1362 (42%)
ABC_membrane 93..359 CDD:294371 116/271 (43%)
ABCC_MRP_domain1 422..622 CDD:213217 107/199 (54%)
ABC_membrane 735..978 CDD:294371 98/315 (31%)
ABCC_MRP_domain2 1051..1272 CDD:213211 138/220 (63%)
Abcc4XP_038948894.1 MRP_assoc_pro 6..1334 CDD:188098 585/1381 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345055
Domainoid 1 1.000 229 1.000 Domainoid score I2384
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H74563
Inparanoid 1 1.050 1102 1.000 Inparanoid score I217
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm44390
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X771
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.810

Return to query results.
Submit another query.