DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and Abcc3

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_542148.2	Gene:	Abcc3 / 140668	RGDID:	71101	Length:	1523	Species:	Rattus norvegicus

Alignment Length:	1373	Identity:	494/1373 - (35%)
Similarity:	753/1373 - (54%)	Gaps:	140/1373 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PEN------PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQ 68
            |||      |...:...|.|.|.:...:...|.::.||..||:...:|..|..:..||..||.:|
  Rat   199 PENLDTNPCPEASAGFFSRLSFWWFTKLAILGYRRPLEDSDLWSLSEEDCSHKVVQRLLEAWQKQ 263

  Fly    69 VA--------------------------KNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQ 107
            ..                          |.:.|...|||.:.|...|.:...|.|.|:.|:.:..
  Rat   264 QTQASGPQTAALEPKIAGEDEVLLKARPKTKKPSFLRALVRTFTSSLLMGACFKLIQDLLSFINP 328

  Fly   108 PICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVF-----SVCIGHPYMLGLLHLGMKMRIALSSL 167
            .  |:.::..|. :||   .|..|...|:||.:|     ...|.|.:...:..:.:::|.|:..:
  Rat   329 Q--LLSILIRFI-SDP---TAPTWWGFLLAGLMFVSSTMQTLILHQHYHCIFVMALRIRTAIIGV 387

  Fly   168 IYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSM 232
            ||||||.::.:...:.|||::|||:|.|..||..|...::.||.|||::|...|.::..:|.|::
  Rat   388 IYRKALTITNSVKREYTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSAL 452

  Fly   233 FGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTR 297
            .|||:::|.:|....:..:....:::.....|.|:::|:||::||:|:|:||||..|.:.||..|
  Rat   453 AGVAVIVLLIPLNGAVSMKMKTYQVQQMKFKDSRIKLMSEILNGIKVLKLYAWEPTFLEQVEGIR 517

  Fly   298 FNEMLCIKQVNYIRGILISFAMFLSRIFTSSSLIAFVLLG--------NILNAEKAFFVTAYYNI 354
            .:|:..:::..|::.  ||..:::...|    ::..:.||        |:|:|||||...:.:||
  Rat   518 QSELQLLRKGAYLQA--ISTFIWVCTPF----MVTLITLGVYVCVDKNNVLDAEKAFVSLSLFNI 576

  Fly   355 LRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPE 419
            |:..:.: .||.||...:..||::|::.|:::.|.   |...|:   :|..||      |..|..
  Rat   577 LKIPLNL-LPQLISGMTQTSVSLKRIQDFLNQDEL---DPQCVE---RKTISP------GRAITI 628

  Fly   420 NLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRIN 484
            :...||     | |..|.|||..:|:|:.:..||||:||||.|||||:.|:|||:....|.:.:.
  Rat   629 HNGTFS-----W-SKDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGAVSVK 687

  Fly   485 GSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSG 549
            ||.:|..|:.|:...|:::|:|||...:..||:..::.|||..|.::||.||:|.:||:|.:|||
  Rat   688 GSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSG 752

  Fly   550 GQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSELVILVTHQLQFLEQA 612
            ||:.|:|||||||..|:|:||||||||||:||.:|:|||.:  .|.|..:..:||||.:.||.|.
  Rat   753 GQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQT 817

  Fly   613 DLIVIMDKGRISAMGTYSSMKRSGLDFAQLLT--AP--NKDAED------------LDEIDGAGG 661
            |.|:::..|:|:.||.||.:.:....||..|.  ||  |::|.:            |::......
  Rat   818 DFIIVLADGQITEMGHYSELLQHDGSFANFLRNYAPDENQEANEGVLQHANEEVLLLEDTLSTHT 882

  Fly   662 DGLD------------LLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVE- 713
            |..|            :..:.|||..|...::|..:..:.:....:..:..:|....::|...|
  Rat   883 DLTDTEPAIYEVRKQFMREMSSLSSEGEGQNRPVLKRYTSSLEKEVPATQTKETGALIKEEIAET 947

  Fly   714 GKIGLGLYKEYLTSGSSWFMIFFMVFLCL---ATQILCSAADYFLSYWV-DKNVDGQTDINTDPQ 774
            |.:.|.:|.:|..|..    :...:|:||   ....:...|:.:||.|. |....||.: ||..:
  Rat   948 GNVKLSVYWDYAKSVG----LCTTLFICLLYAGQNAVAIGANVWLSAWTNDVEEHGQQN-NTSVR 1007

  Fly   775 DMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKD 839
             :..:|.|.:...:..::........|::::..||.|:.....||...||:|.||||||||||||
  Rat  1008 -LGVYATLGILQGLLVMLSAFTMVVGAIQAARLLHTALLHNQIRAPQSFFDTTPSGRILNRFSKD 1071

  Fly   840 LGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLE 904
            :..:||||...:|.:...|.|.:..||||..:.|.:.::.|.||:.:.:::.||:.|||.:||||
  Rat  1072 IYVIDEVLAPTILMLFNSFYTSISTIVVIVASTPLFCVVVLPLAVFYGFVQRFYVATSRQLKRLE 1136

  Fly   905 AVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLD----C 965
            :|:||||:||.|.|:||...|||.|..::.....|...|.:....|.::|:||..|.:::    |
  Rat  1137 SVSRSPIFSHFSETVTGTSVIRAYGRVQDFKVLSDAKVDSNQKTTYPYIASNRWLGVHVEFVGNC 1201

  Fly   966 ---FCTLYIVI--IILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVE 1025
               |..|:.||  ..||        ||.|||:::.|:.:|..:.|.:|..::||:.:.|||||.|
  Rat  1202 VVLFSALFAVIGRNSLN--------PGLVGLSVSYALQVTLSLNWMIRTLSDLESNIIAVERVKE 1258

  Fly  1026 YDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGR 1090
            |.:.|.|..:.....:.|. .||..|.:...:..:||  .|..:.|||.|...::..||||||||
  Rat  1259 YSKTETEAPWVLESNRAPE-GWPRSGVVEFRNYSVRY--RPGLELVLKNLTLHVQGGEKVGIVGR 1320

  Fly  1091 TGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEE 1154
            |||||||:...||| |...||.|.||..:.|.:||.||||:::||||:|:||||::|.|||||..
  Rat  1321 TGAGKSSMTLCLFRILEAAEGEIFIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGR 1385

  Fly  1155 YNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATA 1219
            |:|..:|..||...|...:|..|.||..:.||||.|.|||||||||||||:||::||||:|||||
  Rat  1386 YSDEDIWRTLELSHLSAFVSSQPTGLDFQCSEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATA 1450

  Fly  1220 NVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIF 1284
            .:|.:||.|||.|||::|.||||||||||||||||.:||||:|.|.:.||.||..|:.:  ..||
  Rat  1451 AIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAA--GGIF 1513

  Fly  1285 HGMVMETG 1292
            :||..:.|
  Rat  1514 YGMAKDAG 1521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	487/1354 (36%)
		ABC_membrane	93..359	CDD:294371	83/278 (30%)
		ABCC_MRP_domain1	422..622	CDD:213217	94/201 (47%)
		ABC_membrane	735..978	CDD:294371	87/255 (34%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	127/221 (57%)
Abcc3	NP_542148.2	MRP_assoc_pro	7..1522	CDD:188098	494/1373 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660