DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and ABCC2

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_000383.2	Gene:	ABCC2 / 1244	HGNCID:	53	Length:	1545	Species:	Homo sapiens

Alignment Length:	1400	Identity:	489/1400 - (34%)
Similarity:	754/1400 - (53%)	Gaps:	153/1400 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAK 71
            :|...||...:|.|||:.:.:...::.||.|:.|..:|::...:|.|:.:|..:.     |...|
Human   188 NESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKF-----ETHMK 247

  Fly    72 NETPRLGRAL-------------TKVFGFH----------------------------------- 88
            .|..:..|||             .::.|.:
Human   248 RELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMK 312

  Fly    89 -LFITGVFLLAQEFLTKVTQPIC------LIGVMAYFAGNDPDRSKAQLWAAGLIAGSVF----- 141
             ||.|...:|.:.||.|:...|.      |:.::..||.   ||. ..||...|.|..:|
Human   313 ALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFAS---DRD-TYLWIGYLCAILLFTAALI 373

  Fly   142 -SVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLIN 205
             |.|:...:.| ...||:|:|.|:.:.:|:|||.||..|..:.|||:.|||:|.|..:...|...
Human   374 QSFCLQCYFQL-CFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNF 437

  Fly   206 VHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMM 270
            :|.||.:.|:::...:.::.|:|.|.:.||.:|:|.:|..:.|..::..::::.....|:|:::|
Human   438 MHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIM 502

  Fly   271 NEIISGIQVIKMYAWEKPFGKVVEMTR---------FNEMLCIK-QVNYIRGILISFAMFLSRIF 325
            |||:|||:::|.:|||..|...|:..|         |:::.|:. .|..:..:|:|...|
Human   503 NEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTF----- 562

  Fly   326 TSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETK 390
               |:...|...|||:|:|||.....:||||..::| .|..||...:..||..|||.::...:.
Human   563 ---SVYVLVDSNNILDAQKAFTSITLFNILRFPLSM-LPMMISSMLQASVSTERLEKYLGGDDL- 622

  Fly   391 VRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAV 455
              |.|.:::      ..|.|         ..::||:....|| |..|.|:.|:||.:...:||||
Human   623 --DTSAIRH------DCNFD---------KAMQFSEASFTWE-HDSEATVRDVNLDIMAGQLVAV 669

  Fly   456 IGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVV 520
            |||||:||||||.|:|||:....|.:.|.|:.:|..|:.|:..||::.|||||.::::.||:.|:
Human   670 IGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVL 734

  Fly   521 KKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHL 585
            :.|||..|.|:||.||...:||:|.:||||||.|||||||.|:..|||||||||||||.|||:|:
Human   735 EACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHI 799

  Fly   586 FDQCM--RGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLL----- 643
            |::.:  .|.|:.:..:||||.:.||.|.|.||::..|.|...|:||::.....:||:.|
Human   800 FNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLR 864

  Fly   644 -TAPNKDA---EDLDEIDGAGGDGLDLLNVP----------------SLSRRGSKNSK--PSTRN 686
             |.|.::|   :..:|.|...|....:..:|                :|||....|.:  .|.||
Human   865 HTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRN 929

  Fly   687 NSFT-SLSSMA--ESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILC 748
            :..| :::|:.  |.:.:...|..:|....||:...:|.||| .....|.|||::...:...:..
Human   930 SLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYL-QAIGLFSIFFIILAFVMNSVAF 993

  Fly   749 SAADYFLSYWV-DKNVDGQTDINTDPQDMY--YFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHN 810
            ..::.:||.|. |..:...||.....:||.  .:.||.:|..:|..:.........:.:|..||.
Human   994 IGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHK 1058

  Fly   811 AMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYY 875
            .:...|.||.|.||:|.|:|||:|||:.|:..:|:.||..:...:..||.::..:|:||:..|.:
Human  1059 QLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVF 1123

  Fly   876 LILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDN 940
            .|:.:.|.||:..::.||:.|||.::||::|.|||||||.|.|::|||.|||...|:..:...:.
Human  1124 TIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEV 1188

  Fly   941 LQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQSPGE-VGLAITQAMGMTGMVQ 1004
            ..|.:....::::.:||.....|:....|.:....|...|......|: ||..::.|:.:|..:.
Human  1189 RIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLN 1253

  Fly  1005 WAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAK 1069
            |.:|.::|:|..:.||||:.||.::|.|..:.:  .|:|.|.||.||:|...:..:||  .|:..
Human  1254 WLVRMTSEIETNIVAVERITEYTKVENEAPWVT--DKRPPPDWPSKGKIQFNNYQVRY--RPELD 1314

  Fly  1070 YVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISI 1133
            .||:.:...|...||:|:|||||||||||.|.||| |....|.|.||..|.|.:||.|||.|::|
Human  1315 LVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTI 1379

  Fly  1134 IPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQL 1198
            |||:|:|||||:|.|||||..|:|.::|.|||...||..::.|..||..:::|.|.|.|:|||||
Human  1380 IPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQL 1444

  Fly  1199 VCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDA 1263
            :||.||:||::::||:|||||.||.:||.|||.||:::|..|||:||||||:||||||:|:|:|.
Human  1445 LCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDN 1509

  Fly  1264 GHLVEFGSPYELLTSSESKIFHGMVMETGQNTFDS 1298
            |.::|.|||.|||.....  |:.|..|.|....:|
Human  1510 GKIIECGSPEELLQIPGP--FYFMAKEAGIENVNS 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	482/1372 (35%)
		ABC_membrane	93..359	CDD:294371	87/287 (30%)
		ABCC_MRP_domain1	422..622	CDD:213217	101/201 (50%)
		ABC_membrane	735..978	CDD:294371	75/245 (31%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	119/221 (54%)
ABCC2	NP_000383.2	SunT	8..1537	CDD:331423	487/1393 (35%)
ABCC2	NP_000383.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..284		4/30 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151615
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.760