DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and Abcc5

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_446376.1	Gene:	Abcc5 / 116721	RGDID:	70913	Length:	1436	Species:	Rattus norvegicus

Alignment Length:	1371	Identity:	439/1371 - (32%)
Similarity:	724/1371 - (52%)	Gaps:	143/1371 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPRERSSPLSSLMFCFALPVLFKGRKK-TLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKNET 74
            ::|.:.:...|.:.|.:..|:.....|| .|..:|::...|...||....||...|.|::  ||.
  Rat    98 QHPVDNAGLFSYMTFSWLSPLAQVVHKKGELLMEDVWPLSKYESSDVNCRRLERLWQEEL--NEV 160

  Fly    75 PRLGRALTKVFGF----HLFITGVFLLAQEFLTKVTQPICLI-GVMAYFAGNDPDRSKAQLWAAG 134
            .....:|.:|...    .|.::.|.|:..: |...:.|..:: .::.|....:.:...:.|...|
  Rat   161 GPDAASLRRVVWIFCRTRLILSIVCLMITQ-LAGFSGPAFVVKHLLEYTQATESNLQYSLLLVLG 224

  Fly   135 LIAGSVFSVCIGHPYMLGL-----LHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSN 194
            |:...|.     ..:.|.|     ...|:::|.|:.::.::|.|:|..  :.:.::|:::|:.||
  Rat   225 LLLTEVV-----RSWSLALTWALNYRTGVRLRGAVLTMAFKKILKLKN--IKEKSLGELINICSN 282

  Fly   195 DVGR-FDLVLINVHYLWIAPLELIAVTYLMY--LEIGISSMFGVAIMLLFLPFQSYLGKRTSVLR 256
            |..| |:...:.   ..:|...::|:..::|  :.:|.:...|.|:.:||.|...::.:.|:..|
  Rat   283 DGQRMFEAAAVG---SLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFVSRLTAYFR 344

  Fly   257 LRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFL 321
            .:....||:||:.|||:::.|:.||||||.|.|.:.|:..|..|...:::..|.:.|.:..|..:
  Rat   345 RKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILEKAGYFQSITVGVAPIV 409

  Fly   322 SRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAF--- 383
            ..|.:..:....:.||..|.|.:||.|...:|.:..::.: .|..:...:|..|:|.|.::.
  Rat   410 VVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKV-TPFSVKSLSEASVAVDRFKSLFLM 473

  Fly   384 --MHRPETKVRD---KSKVKNANQKAESPNGD----------------SPKGNGIPENLIEFSQF 427
              :|..:.|...   |.::|||....:|.:..                :|||.......::.::.
  Rat   474 EEVHMIKNKPASPHIKIEMKNATLAWDSSHSSTQSSPKLTPKVKKDKRAPKGKKEKSRQLQHTEH 538

  Fly   428 Q---ARWESH------------------------SLEPTLEDINLQLGRRKLVAVIGPVGAGKSS 465
            |   |..:.|                        .|:.||.:|:|::...|||.:.|.||:||:|
  Rat   539 QAVLAEQKGHLLLDSDERPSPEEEEGKQIHAGSMRLQRTLYNIDLEIEEGKLVGICGSVGSGKTS 603

  Fly   466 LIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFE 530
            ||.||||::....|::.::|:::|.||:.|:...|:|.|||||.::|:.||.:|:..|.|..|..
  Rat   604 LISAILGQMTLLEGSIAVSGTFAYVAQQAWILNATLRDNILFGKEFDEERYNSVLNSCCLRPDLA 668

  Fly   531 LLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLR 595
            :||..|.|.:|||||:|||||:.|||||||:|....||:|||||||:|.|||.|:|:..:|..|:
  Rat   669 ILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKRLK 733

  Fly   596 SELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLT------APNKDAEDLD 654
            |:.|:.||||||:|...|.::.|.:|.|:..||:..:.....|:|.:..      .|..:.....
  Rat   734 SKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKK 798

  Fly   655 EIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKIGLG 719
            |..|:             .:...|..||.       |:.......::|..|...|.:.:|.:...
  Rat   799 EASGS-------------QKSQDKGPKPG-------SVKKEKAVKSEEGQLVQVEEKGQGSVPWS 843

  Fly   720 LYKEYL--TSGSSWFMIFFMVFLCLATQILCSAADYFLSYWV----------DKNVDGQTDINTD 772
            :|..|:  ..|...|::..::|:........|.  ::||||:          :.|....:|...|
  Rat   844 VYWVYIQAAGGPLAFLVIMVLFMLNVGSTAFST--WWLSYWIKQGSGNSTVFEGNRSSVSDSMRD 906

  Fly   773 PQDMYYFA---ALNVAV-VVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRIL 833
            ...:.|:|   ||::|| ::...:|.::|.|..:|:|::||:.:::.|.|:.|.||:|.|:||||
  Rat   907 NPFLQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 971

  Fly   834 NRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICI-----TNPYYLILTLALAIIFYYIREFY 893
            ||||||:.::|..||.    ..::|:..: |:|..|:     ..|::|:....|.|:|..:....
  Rat   972 NRFSKDMDEVDVRLPF----QAEMFIQNV-ILVFFCVGMIAGVFPWFLVAVGPLLILFSVLHIVS 1031

  Fly   894 LKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRA 958
            ....|::|||:.:.:||..||::::|.||.||.|...::|.:..:..|.|.:.:.::.|....|.
  Rat  1032 RVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMRW 1096

  Fly   959 FGYYLDCFCTLYIVIIILNYFINPPQSPGE-VGLAITQAMGMTGMVQWAMRQSAELENTMTAVER 1022
            ....||......|....|...:...|.|.. .||||:.|:.:||:.|:.:|.::|.|...|:|||
  Rat  1097 LAVRLDLISIALITTTGLMIVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVER 1161

  Fly  1023 VVEYDE---IEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEK 1084
            :..|.:   :|.....   :.|.|...||::|||..|:..:||  ......|||.::|.|:|.||
  Rat  1162 INHYIKTLSLEAPARI---KNKAPPHDWPQEGEITFENAEMRY--RENLPLVLKKVSFTIKPKEK 1221

  Fly  1085 VGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYN 1148
            :|||||||:|||||..||||| ..:.|.|.||....:|:||.|||||::|||||||||||::|.|
  Rat  1222 IGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLTIIPQEPVLFSGTVRSN 1286

  Fly  1149 LDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLV 1213
            ||||.:|.:.::|||||...:|..|::||..|:|::.|.|.|||||:|||:|:|||:||..::|:
  Rat  1287 LDPFNQYTEEQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILI 1351

  Fly  1214 MDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTS 1278
            :|||||.:|.:||.|||.|||..|.|||:|||||||:|::.|||::|:..|.:|||.:|..||::
  Rat  1352 LDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSN 1416

  Fly  1279 SESKIF 1284
            ..|:.:
  Rat  1417 DSSRFY 1422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	437/1361 (32%)
		ABC_membrane	93..359	CDD:294371	66/274 (24%)
		ABCC_MRP_domain1	422..622	CDD:213217	93/226 (41%)
		ABC_membrane	735..978	CDD:294371	74/261 (28%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	123/221 (56%)
Abcc5	NP_446376.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..38
		PLN03130	100..1424	CDD:215595	439/1369 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..569		7/69 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..822		6/46 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660