DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and ABCC4

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_005836.2	Gene:	ABCC4 / 10257	HGNCID:	55	Length:	1325	Species:	Homo sapiens

Alignment Length:	1344	Identity:	582/1344 - (43%)
Similarity:	847/1344 - (63%)	Gaps:	90/1344 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKN 72
            |:..||.:.::..|.:.|.:..|:...|.|:.||:.|:|..|.|.:|..||:.|...||::|.:.
Human     7 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRA 71

  Fly    73 ET----PRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRS----KAQ 129
            |.    |.|.||:.|.:.....:.|:|.|.:| ..||.|||.|..::.||...||..|    .|.
Human    72 ENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEE-SAKVIQPIFLGKIINYFENYDPMDSVALNTAY 135

  Fly   130 LWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSN 194
            .:|..|...::....:.|.|...:...||::|:|:..:|||||||||..|:|.||.||:||||||
Human   136 AYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSN 200

  Fly   195 DVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRT 259
            ||.:||.|.:.:|:||..||:.||||.|:::|||||.:.|:|::::.||.||..||..|.||.:|
Human   201 DVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKT 265

  Fly   260 ALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRI 324
            |..||.|:|.|||:|:||::||||||||.|..::...|..|:..|.:.:.:||      |.|:..
Human   266 ATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRG------MNLASF 324

  Fly   325 FTSSSLIAF------VLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAF 383
            |::|.:|.|      ||||:::.|.:.|.....|..:|.:||:|||..|...:|.:||:||::.|
Human   325 FSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTF 389

  Fly   384 MHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLG 448
            :...|...|::          :.|: |..|       ::....|.|.|:..|..|||:.::..:.
Human   390 LLLDEISQRNR----------QLPS-DGKK-------MVHVQDFTAFWDKASETPTLQGLSFTVR 436

  Fly   449 RRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDK 513
            ..:|:||:||||||||||:.|:||||....|.:.::|..:|.:|:||:|:||:|.|||||..::|
Human   437 PGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEK 501

  Fly   514 HRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVD 578
            .||..|:|.|||::|.:||..||.|::|:||.:||||||||::||||||:.||||||||||||||
Human   502 ERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVD 566

  Fly   579 THVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLL 643
            ..|.||||:.|:...|..::.||||||||:|:.|..|:|:..|::...|||:...:||:||..||
Human   567 AEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL 631

  Fly   644 TAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRR--------GSKNSKPSTRNNSFTSLSSMAESMA 700
            ...|:::|. ..:.|          .|:|..|        ..::|:||.::.:..|..:  |::.
Human   632 KKDNEESEQ-PPVPG----------TPTLRNRTFSESSVWSQQSSRPSLKDGALESQDT--ENVP 683

  Fly   701 QEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDK---- 761
            ...|   :|.|.|||:|...||.|..:|:.|.:..|::.|..|.|:.....|::||||.:|
Human   684 VTLS---EENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSML 745

  Fly   762 --------NVDGQTDINTDPQDMYY---FAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQG 815
                    ||..:.|:|      :|   ::.|.||.|:|.|.|::|.:.:.:.||..|||.|::.
Human   746 NVTVNGGGNVTEKLDLN------WYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFES 804

  Fly   816 ITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTL 880
            |.:|.:.||:.||.||||||||||:|.||::||...||.:|..|.::|::.|.....|:..|..:
Human   805 ILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLV 869

  Fly   881 ALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLH 945
            .|.|||.::|.::|:|||||||||:..|||::||||:::.||.||||..|::.....||..||||
Human   870 PLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLH 934

  Fly   946 SSGYYTFLATNRAFGYYLDCFCTLYIVIIIL-NYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQ 1009
            |..::.||.|:|.|...||..|.::::|:.. :..:......|:||||::.|:.:.||.||.:||
Human   935 SEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQ 999

  Fly  1010 SAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKA 1074
            |||:||.|.:||||:||.::|.|..::.:  |:|.|:||.:|.||.:::...|  .|....|||.
Human  1000 SAEVENMMISVERVIEYTDLEKEAPWEYQ--KRPPPAWPHEGVIIFDNVNFMY--SPGGPLVLKH 1060

  Fly  1075 LNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGLFDLRSKISIIPQEPV 1139
            |...|:..|||||||||||||||||:||||||..||.|.||:..|.::||.|||.|:||||||||
Human  1061 LTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPV 1125

  Fly  1140 LFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARA 1204
            ||:|:||.|||||.|:.|.:||:||:||:||..|.:||..:.::::|.|||||||||||||||||
Human  1126 LFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARA 1190

  Fly  1205 ILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEF 1269
            |||:|::|::|||||||||:||.|||..||.||..|||||||||||||:|||:::|:|:|.|.|:
Human  1191 ILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEY 1255

  Fly  1270 GSPYELLTSSESKIFHGMVMETGQNTFDSLLKVAEKAHLESMKP 1313
            ..||.||.:.|| :|:.||.:.|:....:|.:.|::.:.:...|
Human  1256 DEPYVLLQNKES-LFYKMVQQLGKAEAAALTETAKQVYFKRNYP 1298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	571/1302 (44%)
		ABC_membrane	93..359	CDD:294371	116/275 (42%)
		ABCC_MRP_domain1	422..622	CDD:213217	104/199 (52%)
		ABC_membrane	735..978	CDD:294371	103/258 (40%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	138/220 (63%)
ABCC4	NP_005836.2	CFTR_protein	11..1269	CDD:273530	574/1309 (44%)
		ABC_membrane	96..365	CDD:294371	116/275 (42%)
		ABCC_MRP_domain1	410..610	CDD:213217	104/199 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..688		6/35 (17%)
		ABC_membrane	718..991	CDD:279056	108/278 (39%)
		ABCC_MRP_domain2	1039..1258	CDD:213211	138/220 (63%)
		PDZ-binding	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151552
Domainoid	1	1.000	226	1.000	Domainoid score	I2519
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1102	1.000	Inparanoid score	I233
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm40263
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910