Protein Alignment Mrp4 and abcc8

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_031756190.1
• Gene: abcc8 / 101730668
• -ID: -
• Length: 1580
• Species: Xenopus tropicalis
• Alignment Length: 1431
• Identity: 429/1431 - (29%)
• Similarity: 709/1431 - (49%)
• Gaps: 223/1431 - (15%)

  Fly    13 PRERSSP--LSSLMFCFALP---VLFKG------------RKKTLEQKDL------YRALKEHKS 54
            |:|...|  |..|...|..|   :|.||            .||.::.|.:      .||:..:.
 Frog   201 PKEVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNTFIKTAHKKPIDLKAIGKLPIAMRAVTNYL- 264

  Fly    55 DSLGDRLCAAWDEQVAKNETPRLGR-----ALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGV 114
                 .|..|:..|.:|:.....|.     ||.:.||..|.::.:|.:..:.| ....|:|:.|:
 Frog   265 -----LLNKAFHSQKSKSSPCPAGPKSIWFALCQAFGRPLILSSIFRIMADML-GFAGPLCISGI 323

  Fly   115 M------------------AYFAGNDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLG----LLHLG 157
            :                  .:|..:....:.|.:.|..|.    |::.:...::..    .:..|
 Frog   324 VHHLSQENKTFHPQPIFLGVFFISSQEFLANAYVLAVLLF----FALLLQRSFLQASYYVAIETG 384

  Fly   158 MKMRIALSSLIYRKALRLSRT--ALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVT 220
            :.:|.|:.:.||.|.:.||.:  ::|:.:.||:.||::.|..:..........||..|:::|...
 Frog   385 INLRGAIQTKIYNKIMHLSTSNMSMGEMSSGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGV 449

  Fly   221 YLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAW 285
            .|:|..:|||::.|..::::..|.|.::..:.|..:..|...::||::..||::.||:::|:|:|
 Frog   450 ILLYYILGISALIGAVVIIVLAPIQYFVATKLSQAQRSTLEYSNERLKKTNEMLRGIKLLKLYSW 514

  Fly   286 EKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLS-RIFTSSS------LIAFVLLGNILNAE 343
            |..|...||.||..||..:|          :||::.| .||.:::      ||.||:..::|:.|
 Frog   515 EHIFHSSVEETRQKEMNSLK----------AFALYTSISIFMNAAIPIAAVLITFVVHVHLLHRE 569

  Fly   344 K-----AFFVTAYYNILRRSVTMFF--PQGISEFAELLVSVRRLEAFMHR--------------- 386
            :     ||...:.::||   ||..|  ...:....:.||||::|..|...
 Frog   570 QFSPAVAFASLSLFHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFFSSEEIGEEVEKCPPSNK 631

  Fly   387 --PETK--------------VRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHS 435
              |:.|              :||.....|:.|:. :||  ..:||   |..|:.:.....|....
 Frog   632 SVPQNKYQAVPLKVVNRKRPIRDDWNHFNSRQRG-APN--PTEGN---EFCIKVTSGFFTWTPDG 690

  Fly   436 LEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTL------------------- 481
             .|.|..|::::.:.:|..::|.||.|||||:.|.|||:...||.:
 Frog   691 -PPALSSIDIRIPQGQLTMIVGQVGCGKSSLLLATLGEMHKISGDVSWNSTVPDSETGEDVNPDK 754

  Fly   482 --------RINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKT 538
                    |..|:.:||:|:|||...||.:||.|...::|.:|:.::..|:|:.|.::||.||:|
 Frog   755 ETAIDVETRRRGAVAYASQKPWLLNATVEENITFESPFNKQKYKAIIDACSLQPDIDILPHGDQT 819

  Fly   539 IVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLR--SELVIL 601
            .:||||.:|||||:.|||:||.:|::..:..||||.||:|.|:..||..:.:...||  ....:|
 Frog   820 QIGERGINLSGGQRQRISVARVLYQQTSVVFLDDPFSALDIHLSDHLMHEGILKMLRDNKRTTVL 884

  Fly   602 VTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLD-FAQLLTAPNKDAEDLDE---ID-GAGG 661
            |||:||:|..||.|:.|..|.|...||...:::|..: :....|..|:..::|::   :| .|||
 Frog   885 VTHKLQYLPHADWIIAMKDGTIQREGTLKDIQKSDPELYEHWKTLMNRQDQELEKEIILDRKAGG 949

  Fly   662 DGLDLLNV--PSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKIGLGLYKEY 724
            :.::|...  |..:..|.........:.|.....:::..:.|.|.:..   |..||        |
 Frog   950 ERMNLTRTIYPRDALLGDDEEDEEEISESEEDDDNLSSVLHQRAKMPW---RACGK--------Y 1003

  Fly   725 LTSGSSWFMIFFMVFLCLATQIL----CSAADYFLSYWVD--------KNVDGQTDINTD--PQD 775
            |:|..     ..::.|.:.:|:|    ..|.|::|:.|..        .|..|:.....|  |..
 Frog  1004 LSSAG-----ILLLPLLVLSQLLKHSVMVAIDFWLAKWTSAAITNLSVANCSGRPTCRFDHSPYS 1063

  Fly   776 MYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDL 840
            | .|:.|:...::..:..::......:|.:.:||:::...|..|.|.||.|.|.|.||||||.|.
 Frog  1064 M-AFSILSCVGIIMCLATSIAVEWTGLRVAKKLHSSLLNAIILAPMRFFETTPLGSILNRFSADF 1127

  Fly   841 GQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEA 905
            ..:|:.:|:.:..:.:..|..:..:.||....|.:||..:.||||.|:|::::...|||:::||.
 Frog  1128 NTIDQHIPATLECLSRSTLLCVSALAVISYVTPVFLISLVPLAIICYFIQKYFRVASRDLQQLED 1192

  Fly   906 VARSPIYSHLSATITGLPTIRALGAQ----KELIAEFD--NLQDLHSSGYYTFL-ATNRAFGYYL 963
            ..:.|:.||.:.|:.||.||||...:    ::|:...|  |:..|       || |.||.....:
 Frog  1193 STQLPLLSHFAETVEGLTTIRAFRYEPRFRQKLLEHTDSNNIASL-------FLTAANRWLEVRM 1250

  Fly   964 DCF--CTLYIVIII-----LNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVE 1021
            :..  |.:.|..:.     |:|.:    |.|.|||.:|.|:.::..:.|.:|..:::|..:.||:
 Frog  1251 EYIGACVVLIAAVASITNSLHYNL----SSGLVGLGLTYALMVSNYLNWMVRNLSDMEIQLGAVK 1311

  Fly  1022 RVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVG 1086
            |:....:.|||.........:..|:|||.|||..::|.:||  |...|.|||.:|..|.|.:|:|
 Frog  1312 RINGLLKTEPENYKGLLSPTQIPPNWPENGEIQIQNLSVRY--DSSLKPVLKHVNAHITPGQKIG 1374

  Fly  1087 IVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLD 1150
            |.||||:||||...|.||: ...:|.|.||..|.|.:.|..|||::|||.|:|:||||::|:|||
 Frog  1375 ICGRTGSGKSSFSLAFFRMVDTFQGRIIIDGIDIAKLPLQTLRSRLSIILQDPILFSGTIRFNLD 1439

  Fly  1151 PFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMD 1215
            |..:..||.||:|||..:||.::..||.||.:.::|||.|||||||||.|||||.:|::.:|:||
 Frog  1440 PENKCTDAMLWEALEIAQLKHVVKVLPGGLDALVTEGGENFSVGQRQLFCLARAFVRKSSILIMD 1504

  Fly  1216 EATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSE 1280
            ||||::|..|:.::|..:.:.|.|.||:|||||::||:::|.|:||..|.::|:..|..||....
 Frog  1505 EATASIDMATENILQKVVMTAFDDRTVVTIAHRVHTILNADLVIVMKRGAIMEYDKPEALLEGGG 1569

  Fly  1281 S 1281
            |
 Frog  1570 S 1570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	427/1425 (30%)
		ABC_membrane	93..359	CDD:294371	71/301 (24%)
		ABCC_MRP_domain1	422..622	CDD:213217	81/228 (36%)
		ABC_membrane	735..978	CDD:294371	73/270 (27%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	110/221 (50%)
abcc8	XP_031756190.1	MRP_assoc_pro	224..1573	CDD:188098	422/1408 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9436
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010