DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mrp4 and ABCC9

DIOPT Version :9

Sequence 1:NP_650086.2 Gene:Mrp4 / 41387 FlyBaseID:FBgn0263316 Length:1316 Species:Drosophila melanogaster
Sequence 2:NP_001364202.1 Gene:ABCC9 / 10060 HGNCID:60 Length:1549 Species:Homo sapiens


Alignment Length:1396 Identity:434/1396 - (31%)
Similarity:699/1396 - (50%) Gaps:200/1396 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LSSLMFCFALPVLFKGRKKTLEQKDL------------YRALKEHKSDSLGDRLCAAWDEQVAK- 71
            ||...:.:...::....||.::.|.:            |..||:            |::||..| 
Human   223 LSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKD------------AYEEQKKKV 275

  Fly    72 ----NETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDR------- 125
                |.||.:..|:.:.||..:.::..|....:.| ....|:|:.|::...  |:...       
Human   276 ADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLL-GFAGPLCISGIVQRV--NETQNGTNNTTG 337

  Fly   126 ------SKAQLWAAGLIAGSVFSVCIGHPYMLG-----LLHLGMKMRIALSSLIYRKALRLSRT- 178
                  ||..|..|.::|..:|...|.....|.     .:..|:.:|.||.::||.|.||||.: 
Human   338 ISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSN 402

  Fly   179 -ALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFL 242
             ::|:.|:||:.||::.:..:....|.....||..|:::|....|:|..:|.|::.|.|:::|..
Human   403 LSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLA 467

  Fly   243 PFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQV 307
            |.|.::..:.:..:..|...:.||::..|||:.||:::|:||||..|.|.||.||..|:..:|  
Human   468 PIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLK-- 530

  Fly   308 NYIRGILISFAMFLS-RIFTSSSL-IAFVLL---------GNILNAEKAFFVTAYYNILRRSVT- 360
                    :||::.| .||.:::: ||.||.         ||.|...:||...:.::||   || 
Human   531 --------TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHIL---VTP 584

  Fly   361 MFFPQGISEFA-ELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAES--PNGDSPKGNGIPENLI 422
            :|....:..|| :.::||::|..|:...|  :.|.|.     :..||  |.....|..|:....|
Human   585 LFLLSTVVRFAVKAIISVQKLNEFLLSDE--IGDDSW-----RTGESSLPFESCKKHTGVQPKTI 642

  Fly   423 EFSQFQARWESHSLE-----------------------------PTLEDINLQLGRRKLVAVIGP 458
            ...| ..|:...|.|                             .||.:|::::...:|..::|.
Human   643 NRKQ-PGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQ 706

  Fly   459 VGAGKSSLIQAILGELPGESGTL---------------RINGSYS--YAAQEPWLFTGTVRQNIL 506
            ||.|||||:.|||||:....|.:               |....||  ||||:|||...||.:||.
Human   707 VGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENIT 771

  Fly   507 FGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLD 571
            ||..::|.||:.|...|:|:.|.:||||||:|.:||||.:|||||:.||.:|||:|:..:|..||
Human   772 FGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLD 836

  Fly   572 DPLSAVDTHVGRHLFDQCMRGYLRSE--LVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKR 634
            ||.||:|.|:..||..:.:..:|:.:  .::||||:||:|..||.|:.|..|.:...||...::.
Human   837 DPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQT 901

  Fly   635 SGLD-FAQLLTAPNKDAEDLDEIDGAGGDGLDL-LNVPSLSRRGSKNSKPSTRNNSFTSLSSMAE 697
            ..:: :....|..|:..::|::         |: .:..:|.|:..:.:..|              
Human   902 KDVELYEHWKTLMNRQDQELEK---------DMEADQTTLERKTLRRAMYS-------------- 943

  Fly   698 SMAQEASLQMQE------------------TRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLAT 744
               :||..||::                  .|:..|:.......||||| .:|::..|:|..|..
Human   944 ---REAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSG-GFFLLILMIFSKLLK 1004

  Fly   745 QILCSAADYFLSYWVDK---NVDGQTDINTDPQDMYYFAALNV---AVVVFTIVRTMLFYKMAMR 803
            ..:..|.||:|:.|..:   |..|:.|      ..||.|..::   |.:...:|.::....|.:.
Human  1005 HSVIVAIDYWLATWTSEYSINNTGKAD------QTYYVAGFSILCGAGIFLCLVTSLTVEWMGLT 1063

  Fly   804 SSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVI 868
            ::..||:.:...|....:.||:|.|.|.||||||.|...:|:.:|..:..:.:..|..|..|.:|
Human  1064 AAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMI 1128

  Fly   869 CITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKE 933
            ....|.:|:..|.|.:.||:|::::...|:|::.|:...:.|:..|.|.|..||.||||...:..
Human  1129 SYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETR 1193

  Fly   934 LIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMG 998
            .......|.|.::..|....|.||......| :....||:......|:...:.|.|||.:..|:.
Human  1194 FKQRMLELTDTNNIAYLFLSAANRWLEVRTD-YLGACIVLTASIASISGSSNSGLVGLGLLYALT 1257

  Fly   999 MTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYF 1063
            :|..:.|.:|..|:||..|.||::|..:..:|.|....:.:..:....||::|||...|||:|| 
Human  1258 ITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRY- 1321

  Fly  1064 PDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDL 1127
             :...|.|||.:...|:|.:||||.||||:|||||..|.||: ...:|.|.||..|.:.:.|..|
Human  1322 -ENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTL 1385

  Fly  1128 RSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFS 1192
            ||::|||.|:|:|||||:|:||||..:..|.:||:|||..:||.::..||.||.:.::|||.|||
Human  1386 RSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFS 1450

  Fly  1193 VGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDR 1257
            ||||||.|||||.:|::.:|:||||||::|..|:.::|..:.:.|.|.||:|||||::||:.:|.
Human  1451 VGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADL 1515

  Fly  1258 VLVMDAGHLVEFGSPYELLTSSESKIFHGMV 1288
            |:||..|:::|:.:| |.|.:.|:.:|...|
Human  1516 VIVMKRGNILEYDTP-ESLLAQENGVFASFV 1545

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mrp4NP_650086.2 CFTR_protein 12..1277 CDD:273530 430/1383 (31%)
ABC_membrane 93..359 CDD:294371 82/296 (28%)
ABCC_MRP_domain1 422..622 CDD:213217 91/247 (37%)
ABC_membrane 735..978 CDD:294371 67/248 (27%)
ABCC_MRP_domain2 1051..1272 CDD:213211 111/221 (50%)
ABCC9NP_001364202.1 MRP_assoc_pro 222..1546 CDD:188098 434/1396 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..967 4/22 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151542
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.650

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