DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mrp4 and ABCC5

DIOPT Version :9

Sequence 1:NP_650086.2 Gene:Mrp4 / 41387 FlyBaseID:FBgn0263316 Length:1316 Species:Drosophila melanogaster
Sequence 2:NP_005679.2 Gene:ABCC5 / 10057 HGNCID:56 Length:1437 Species:Homo sapiens


Alignment Length:1400 Identity:455/1400 - (32%)
Similarity:742/1400 - (53%) Gaps:166/1400 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ENPRERSSPLSSLMFCFALPVLFKGRKK-TLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKNET 74
            ::|.:.:...|.:.|.:...:.....|| .|..:|::...|...||....||...|.|::  ||.
Human    98 QHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEEL--NEV 160

  Fly    75 PRLGRALTKVFGF----HLFITGVFLLAQEFLTKVTQPICLI-GVMAYFAGNDPDRSKAQLWAAG 134
            .....:|.:|...    .|.::.|.|:..: |...:.|..:: .::.|....:.:...:.|...|
Human   161 GPDAASLRRVVWIFCRTRLILSIVCLMITQ-LAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLG 224

  Fly   135 LIAGSVFSVCIGHPYMLGL-----LHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSN 194
            |:...:.     ..:.|.|     ...|:::|.|:.::.::|.|:|..  :.:.::|:::|:.||
Human   225 LLLTEIV-----RSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN--IKEKSLGELINICSN 282

  Fly   195 DVGR-FDLVLINVHYLWIAPLELIAVTYLMY--LEIGISSMFGVAIMLLFLPFQSYLGKRTSVLR 256
            |..| |:...:.   ..:|...::|:..::|  :.:|.:...|.|:.:||.|...:..:.|:..|
Human   283 DGQRMFEAAAVG---SLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFR 344

  Fly   257 LRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFL 321
            .:....|||||:.|||:::.|:.||||||.|.|.:.|:..|..|...:::..|.:.|.:..|..:
Human   345 RKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIV 409

  Fly   322 SRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAF--- 383
            ..|.:..:....:.||..|.|.:||.|...:|.:..::.: .|..:...:|..|:|.|.::.   
Human   410 VVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKV-TPFSVKSLSEASVAVDRFKSLFLM 473

  Fly   384 --MHRPETKVRD---KSKVKNANQKAESPNG---DSPK-----------GNGIPENLIEFSQFQ- 428
              :|..:.|...   |.::|||....:|.:.   :|||           ..|..|.:.:..:.: 
Human   474 EEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEH 538

  Fly   429 ----ARWESH------------------------SLEPTLEDINLQLGRRKLVAVIGPVGAGKSS 465
                |..:.|                        .|:.||..|:|::...|||.:.|.||:||:|
Human   539 QAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTS 603

  Fly   466 LIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFE 530
            ||.||||::....|::.|:|:::|.||:.|:...|:|.|||||.::|:.||.:|:..|.|..|..
Human   604 LISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLA 668

  Fly   531 LLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCMRGYLR 595
            :||..|.|.:|||||:|||||:.|||||||:|....||:|||||||:|.|||.|:|:..:|.:|:
Human   669 ILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLK 733

  Fly   596 SELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLT------APNKDAEDLD 654
            |:.|:.||||||:|...|.::.|.:|.|:..||:..:.....|:|.:..      .|..:.....
Human   734 SKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKK 798

  Fly   655 EIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMA---QEASLQMQETRVEGKI 716
            |..|              |::.|::..|.|        .|:.:..|   :|..|...|.:.:|.:
Human   799 ETSG--------------SQKKSQDKGPKT--------GSVKKEKAVKPEEGQLVQLEEKGQGSV 841

  Fly   717 GLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAA--DYFLSYWVDKNVDGQT-----------D 768
            ...:|..|:.:...  .:.|:|.:.|....:.|.|  .::||||: |...|.|           |
Human   842 PWSVYGVYIQAAGG--PLAFLVIMALFMLNVGSTAFSTWWLSYWI-KQGSGNTTVTRGNETSVSD 903

  Fly   769 INTDPQDMYYFA---ALNVAV-VVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPS 829
            ...|...|.|:|   ||::|| ::...:|.::|.|..:|:|::||:.:::.|.|:.|.||:|.|:
Human   904 SMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPT 968

  Fly   830 GRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICI-----TNPYYLILTLALAIIFYYI 889
            ||||||||||:.::|..||.    ..::|:..: |:|..|:     ..|::|:....|.|:|..:
Human   969 GRILNRFSKDMDEVDVRLPF----QAEMFIQNV-ILVFFCVGMIAGVFPWFLVAVGPLVILFSVL 1028

  Fly   890 REFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLA 954
            ........|::|||:.:.:||..||::::|.||.||.|....:|.:..:..|.|.:.:.::.|..
Human  1029 HIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTC 1093

  Fly   955 TNRAFGYYLD-----CFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELE 1014
            ..|.....||     ...|..::|::::..|    .|...||||:.|:.:||:.|:.:|.::|.|
Human  1094 AMRWLAVRLDLISIALITTTGLMIVLMHGQI----PPAYAGLAISYAVQLTGLFQFTVRLASETE 1154

  Fly  1015 NTMTAVERVVEYDE---IEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALN 1076
            ...|:|||:..|.:   :|.....   :.|.|||.||::||:..|:..:||  ......|||.::
Human  1155 ARFTSVERINHYIKTLSLEAPARI---KNKAPSPDWPQEGEVTFENAEMRY--RENLPLVLKKVS 1214

  Fly  1077 FRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVL 1140
            |.|:|.||:|||||||:|||||..||||| ..:.|.|.||....:|:||.|||||:|||||||||
Human  1215 FTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVL 1279

  Fly  1141 FSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAI 1205
            |||::|.|||||.:|.:.::|||||...:|..|::||..|:|::.|.|.|||||:|||:|:|||:
Human  1280 FSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARAL 1344

  Fly  1206 LRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFG 1270
            ||..::|::|||||.:|.:||.|||.|||..|.|||:|||||||:|::.|||::|:..|.:|||.
Human  1345 LRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFD 1409

  Fly  1271 SPYELLTSSESKIFHGMVMETGQNTFDSLLKVAEK 1305
            :| .:|.|::|..|:.| ....:|      |||.|
Human  1410 TP-SVLLSNDSSRFYAM-FAAAEN------KVAVK 1436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mrp4NP_650086.2 CFTR_protein 12..1277 CDD:273530 445/1369 (33%)
ABC_membrane 93..359 CDD:294371 66/274 (24%)
ABCC_MRP_domain1 422..622 CDD:213217 93/228 (41%)
ABC_membrane 735..978 CDD:294371 80/269 (30%)
ABCC_MRP_domain2 1051..1272 CDD:213211 123/221 (56%)
ABCC5NP_005679.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..41
CFTR_protein 100..1430 CDD:273530 450/1384 (33%)
ABC_membrane <271..447 CDD:294371 50/178 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..538 6/36 (17%)
ABCC_MRP_domain1 577..759 CDD:213217 90/181 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 794..827 8/54 (15%)
ABC_membrane 863..1143 CDD:294371 87/289 (30%)
ABCC_MRP_domain2 1191..1411 CDD:213211 123/221 (56%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151532
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.660

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