Protein Alignment Mrp4 and abcc12

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_002937916.3
• Gene: abcc12 / 100493828
• XenbaseID: XB-GENE-6465370
• Length: 1430
• Species: Xenopus tropicalis
• Alignment Length: 1449
• Identity: 434/1449 - (29%)
• Similarity: 727/1449 - (50%)
• Gaps: 203/1449 - (14%)

  Fly     1 MQSMKADELPENPRERSSPLSSLMFCFALPVLFKGRK-KTLEQKDLYRALKEHKSDSLGDRLCAA 64
            ::..:|....::|.:.:...|.:...:..|:..|..| ..|:..||:.......|::...||.:.
 Frog    19 LKPFRATHRNQHPIDNAGLFSFMTLNWITPLARKAYKLSELQMNDLWSLPFHESSETNCQRLQSL 83

  Fly    65 WDEQVAKNETPRLGRALT-----KVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPD 124
            |:|::..:...:...:|.     :......|::.:..:...|:    .|...|..:..:|    :
 Frog    84 WEEELQNHGKRKASLSLVLWRFCRTRSLLAFLSLIITMTASFI----GPAIFIRALLEYA----N 140

  Fly   125 RSKAQLWAAGLIAGSVFSVCIGHPYMLGL-----LHLGMKMRIALSSLIYRKALRLSRTALGDTT 184
            ..|..|....::|..:|:..:...:...|     ...|::::.|:.:|.::|.|:|.::  .|..
 Frog   141 TLKHDLRYGLILASGIFAAELVRSWSFALHWAMNYRTGVRLKGAVLALAFKKMLKLKQS--NDIR 203

  Fly   185 VGQVVNLLSNDVGR-FDLVLINVHYLWIAPLELIAVTYLMY--LEIGISSMFGVAIMLLFLPFQS 246
            .|:::|:.|:|..| |:...|.   ..:|...:|.:..|:|  |.:|.|::.|.::.::|.||..
 Frog   204 TGELLNMCSSDGQRLFEAASIG---CMLAAGPVIGIMGLVYTALFLGPSALLGSSVFIIFYPFMM 265

  Fly   247 YLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIR 311
            ...|.|:..|.:..:.||.|||:||||::.|:.|||||||..|...::..|..|...:::..|::
 Frog   266 LASKLTAYFRKKCIVVTDRRVRLMNEILNSIKFIKMYAWENTFRNKIQDIRSEEKTFLEKAGYVQ 330

  Fly   312 GILISFAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVS 376
            .|....|..:..:.:..:....:.||..|||.:||.|...:|.:..::.| .|..:...:|..:|
 Frog   331 SITSGVAPVVVVVASVCTFTLHMALGYNLNAAEAFTVVTVFNSMTSALKM-IPLAVKAASEASIS 394

  Fly   377 VRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLE 441
            :.|.:......|:.:|:..::                   :..:||:||.....|.|.....|||
 Frog   395 ISRFQKLFLMEESDMRNNQRL-------------------LSNDLIDFSGAYFSWSSDVRSSTLE 440

  Fly   442 ----------------------------------------------------DINLQLGRRKLVA 454
                                                                :||..:.:.||:.
 Frog   441 KQKEAEQKQEEFKETQNLINGHYLFSSSESKQIVNGTNASEYIVCEHKAALININFTVQKSKLIG 505

  Fly   455 VIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTV 519
            :.|.||:||:|||.:|||::....||:.::|..:||||:.|:|..::|:|||||.::.:.:|:.|
 Frog   506 ICGSVGSGKTSLILSILGQMTLLEGTVTVSGRIAYAAQQAWIFNESLRENILFGEEYKEKKYQRV 570

  Fly   520 VKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRH 584
            :|.|.|..|.|.||.||.|.:||||.:|||||:.|||||||:|....:.||||||||||..||..
 Frog   571 LKTCCLYPDIESLPHGDLTEIGERGTNLSGGQRQRISLARALYSERSVVLLDDPLSAVDVQVGAQ 635

  Fly   585 LFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQL------- 642
            ||.:.::..:.:.:|:.||||||:|.:.|.:::|..|.|:..||:..:.:...|:|.|
 Frog   636 LFKKAIKHGMMNRIVLFVTHQLQYLVECDEVLMMKNGSIAEQGTHEELMKYQGDYAVLFQSMQQV 700

  Fly   643 ----------------------------LTAPNKDAEDLDEI-----------DGAGGDGL---- 664
                                        :...:|:...|.|:           :....|.|
 Frog   701 NSIKSDVQCSPMKYEQLDRQVTSSHHATVVQQSKEQGTLSELTNQEETGHFTSEDVSADHLTHKS 765

  Fly   665 DLLNVPSLSRRG------------------SKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETR 711
            :::|...:...|                  .::.|.|...|:..    :..:..|...|...|.:
 Frog   766 EMVNRDFMVTDGQITGCKQADQYGDQEDDADEDEKGSVLGNTII----VNNNERQNRDLMEPEEK 826

  Fly   712 VEGKIGLGLYKEYL-TSGSSWFMIFFMVFLCLATQILCSAADYFLSYW----------VDKNVDG 765
            ..|.:...:|..|: .:|.:.|.:...|.....|..: :.::::||||          |..||..
 Frog   827 GCGSVPCPIYWVYIKAAGGALFCVLNAVLFIFTTGSM-AFSNWWLSYWIKQGSGNTSVVTSNVTL 890

  Fly   766 QTDINTDPQDM----YYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNT 826
            .:|..:|..|:    |.:.:...||:.|..:|..:|.|..:::||:||:.::|.:..:.:..|:|
 Frog   891 SSDNMSDNPDLEFYIYVYISTLAAVLGFRFIRGYVFVKSTLKASTKLHDQLFQKVLHSPLKLFDT 955

  Fly   827 NPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIRE 891
            .|.|||||||:||:.::|..||..:..::|..:.:|..:.:|....|::|:..|.|:|:|:.|.:
 Frog   956 TPLGRILNRFTKDMDEVDARLPCQLEQLIQNMILVLFCLGMISFVFPWFLVSVLPLSILFFLINK 1020

  Fly   892 FYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATN 956
            ......|::|||:.:::||..||::|::.|:.||:|.....:.|..|..|.|::....:.|...:
 Frog  1021 VSRVLIRELKRLDNISQSPFLSHVTASLHGITTIQAYNKNTDFILRFQKLLDINQVPCFLFSCAS 1085

  Fly   957 RAFGYYLDCF----CTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTM 1017
            |.....||..    .||..|.|:|.:...|   |...||||:.|:.:||:.|:.:|...|.|...
 Frog  1086 RWLAVRLDLISMIVITLTSVCIVLMHGHIP---PAYAGLAISYAVQLTGLFQYTVRLVTETEARF 1147

  Fly  1018 TAVERVVEY-DEIEPEGEFDSREGKKPSP-SWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIR 1080
            |:|||:..| ..:|.|   :..:.|:.:| :||::|.|..|::.:||  ..:...|||.::|.||
 Frog  1148 TSVERINHYIKNLESE---EPLKAKEITPKTWPQEGAITFENVEMRY--RDKLPLVLKNISFSIR 1207

  Fly  1081 PCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGS 1144
            |.||:|||||||:|||||...|||| ....|.:|||......:||.:||.|:|::||:||||.||
 Frog  1208 PKEKIGIVGRTGSGKSSLGMVLFRLVDLAGGSVTIDNFCINTIGLKNLRGKLSVLPQDPVLFVGS 1272

  Fly  1145 MRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILREN 1209
            :|.||||...:.|.::|:|||...:|..:|:|...|..::||.|||||||:|||:|:|||:||.:
 Frog  1273 IRSNLDPLNLHTDEEVWNALERTHMKQHVSKLVGKLNYEVSENGSNFSVGERQLLCMARALLRSS 1337

  Fly  1210 RVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYE 1274
            :||::|||||.:|.:||||||.|::..|.|||||.||||||||:..||::|||.|.:|||..|..
 Frog  1338 KVLLLDEATAAIDNETDALIQETVKEAFHDCTVLIIAHRLNTILHCDRIMVMDKGKIVEFEKPSV 1402

  Fly  1275 LLTSSESKIFHGMVMETGQ 1293
            ||::.:|: ||.|..:..|
 Frog  1403 LLSNKKSR-FHAMATQWQQ 1420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	432/1434 (30%)
abcc12	XP_002937916.3	MRP_assoc_pro	27..1415	CDD:188098	431/1434 (30%)