Protein Alignment Mrp4 and LOC100493583

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_031752469.1
• Gene: LOC100493583 / 100493583
• -ID: -
• Length: 1289
• Species: Xenopus tropicalis
• Alignment Length: 1339
• Identity: 465/1339 - (34%)
• Similarity: 737/1339 - (55%)
• Gaps: 110/1339 - (8%)

  Fly    11 ENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAK---- 71
            :||.:.:|.||.|.:.:...::..|.||.||::||:.......|.::.......|..:||:
 Frog    22 DNPEKNASLLSRLTYSWYSRIITLGYKKPLEREDLFELNDNDSSYTVIPIFEKNWRNEVARQAQK 86

  Fly    72 ---NETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAA 133
               ::...|.|||...|.:.| |...|:.....:...:.|..|..::| |....||..    |..
 Frog    87 GTVSKNVSLLRALWNTFKYSL-IQVAFMKVIADILAFSSPQILKRMIA-FTEERPDEG----WTG 145

  Fly   134 GLIAGSVFSVCIGHPYMLGL-----LHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLS 193
            ..:|..:..|.:....:|.|     :...:||:.::..|||||||:|:.::....|.|::|||:|
 Frog   146 YALALLLLVVTVSQTLILQLYQRFNMLAAVKMKTSVIGLIYRKALQLAYSSRKKFTTGELVNLMS 210

  Fly   194 NDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLR 258
            :|..:...:.:|::.||.||.:::.....::.|:|.|.:.||.:::|.:|..:::..|...|:..
 Frog   211 SDAQQLMDLTVNLNLLWSAPFQILMAVVFLWQELGASVLAGVGVLILVIPINAFIASRVKQLKKS 275

  Fly   259 TALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMF--- 320
            .....|:|::::|||:.||:::|:||||..:.:.|...|.:||..:|...|    |.:|:|.
 Frog   276 HLKSKDQRIKLLNEILHGIKILKLYAWEPSYQRKVADIRESEMDVLKSSGY----LTTFSMLTLT 336

  Fly   321 -LSRIFTSSSLIAFVLL--GNILNAEKAFFVTAYYNILRRSVTMF-FPQGISEFAELLVSVRRLE 381
             :..:.:.::...:.||  .|:|.|.|.|...:.:||||  :.:| .|..||...:..||:.|||
 Frog   337 CIPFLVSMATFGVYFLLDDANVLTASKVFTTISLFNILR--LPLFDLPTVISSVVQTRVSLGRLE 399

  Fly   382 AFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPT-LEDINL 445
            .|.               ..::..:.|.:: |.:|  .:.:.||....:|:...  |: |:|::.
 Frog   400 NFF---------------CGEEINTENIET-KYSG--SHAVGFSGASFQWDKTG--PSILKDLDF 444

  Fly   446 QLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLD 510
            ::....||||:|.||:|||||:.|||||:....|.::..|:.:|.:|:.|:.....::||||||.
 Frog   445 KIPEGSLVAVVGQVGSGKSSLLSAILGEMNTLEGKVQRKGAVAYVSQQAWIQNALFQENILFGLA 509

  Fly   511 WDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLS 575
            ::|..|..|::.|||..|.||||.||:|.:||||.:||||||.|:|||||||..|||||||||||
 Frog   510 FNKQHYERVLEACALLPDLELLPNGDQTEIGERGVNLSGGQKQRVSLARAVYSNADIYLLDDPLS 574

  Fly   576 AVDTHVGRHLFDQCM--RGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLD 638
            |||.|||:||||:.:  :|.::::..:||||.|..|.|.|||::|::||.:.:|||..:.....:
 Frog   575 AVDVHVGKHLFDKLIGPKGLIKNKTRVLVTHSLTVLPQTDLIIVMEEGRAAHIGTYQELMSKRQN 639

  Fly   639 FAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPS--TRNNSFTSLSSMAESMAQ 701
            ||.::...||..|:....|.||     :...|...:|.....:..  .::.:.|.:|.| .||.:
 Frog   640 FADMIQTFNKGTENEQLSDTAG-----VFRDPKALQRTKSQHEDGFIKKDRTLTEMSKM-PSMKK 698

  Fly   702 EASLQMQETRVEGKIGLGLYKEYLTS-GSSWFMIFFMVFLCLATQILCSAADYFLSYWVD----- 760
            |..       ..|.:.:.:..:||.: |.||  ::|.|...:....|....:.:||.|..
 Frog   699 EKV-------ATGNMRMSIVMKYLYAFGWSW--VWFTVIAYIGQNALAVGQNVWLSRWATEAKGI 754

  Fly   761 KNVDGQTDINTDPQDMY----YFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAM 821
            :.....|::..:...:|    :...:.|....:.:.|..:.      :|..|||.|...:....:
 Frog   755 RETSEWTELRNNRLGIYGLLGFVQGILVCYGAYVVTRGTIC------ASRLLHNQMLDNVLHLPL 813

  Fly   822 YFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIF 886
            .||.|.|.|::||||:||:..:||.....:...:...|.:||.|:||....|.:::..:.|..::
 Frog   814 QFFETTPMGQLLNRFTKDVYVIDERFHYYLRTWLNCMLDVLGTIIVIVYATPIFILAVVPLGFLY 878

  Fly   887 YYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYT 951
            ..|:.:|:.:||.::||:..:|||:.||...|:.|.|||||.|.|:..|.:..::.:.:...||.
 Frog   879 LLIQRYYISSSRQIRRLDGASRSPVISHFGETLMGAPTIRAYGHQERFINQNKDVVNENLVCYYN 943

  Fly   952 FLATNRAFGYYLDCFCTLYIVIIILNYF---INPPQSPGEVGLAITQAMGMTGMVQWAMRQSAEL 1013
            .:.:||.....|:...:|.|....|  |   .....:.|.|||:||.|:.:|..:.:.:|::.|:
 Frog   944 NVISNRWLAVRLEFLGSLMIFFAAL--FAVQAGDKMNSGIVGLSITYALNITQTLNFWVRKACEI 1006

  Fly  1014 ENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFR 1078
            |....|:||:.||:|::.|..:..  ||:|...||::|.|...:...||..|..  ..|:.:.||
 Frog  1007 ETNGVAIERICEYEEMQKEAPWIM--GKRPPVRWPDQGIIEFVNYKARYREDHD--LALQDITFR 1067

  Fly  1079 IRPCEKVGIVGRTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFS 1142
            :...||:|||||||||||:|.|.||| :....|.|.||..|.|.:||.|||||::||||:|||||
 Frog  1068 LHATEKLGIVGRTGAGKSTLTNCLFRTVEGTGGKIIIDGIDIATIGLHDLRSKLNIIPQDPVLFS 1132

  Fly  1143 GSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILR 1207
            |:::.||||.|:::||:||:|||...|||.:..||..|...|||||.|.|||||||:|||||:||
 Frog  1133 GTLQMNLDPLEQHSDAELWEALELCHLKPFVMSLPKRLYHDISEGGENLSVGQRQLICLARALLR 1197

  Fly  1208 ENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSP 1272
            :.::||:|||||::|.:||.|:|||||..|.|||||||||||::::||:||||:|||.:||||.|
 Frog  1198 KAKILVLDEATASIDMETDNLVQATIRKAFSDCTVLTIAHRLHSVLDSERVLVLDAGRVVEFGEP 1262

  Fly  1273 YELLTSSESK-IFHGMVMETGQNTFDSLLKVAEKAHLES 1310
            ..|:   |.| .|..|:.|.         |:.:..|.|:
 Frog  1263 QRLI---EKKGYFSRMISEA---------KILQSGHAEN 1289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	457/1302 (35%)
		ABC_membrane	93..359	CDD:294371	75/276 (27%)
		ABCC_MRP_domain1	422..622	CDD:213217	99/202 (49%)
		ABC_membrane	735..978	CDD:294371	65/251 (26%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	128/221 (58%)
LOC100493583	XP_031752469.1	MRP_assoc_pro	24..1279	CDD:188098	460/1316 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920