Protein Alignment Mrp4 and abcc6

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_002932264.3
• Gene: abcc6 / 100493037
• XenbaseID: XB-GENE-6465366
• Length: 1500
• Species: Xenopus tropicalis
• Alignment Length: 1370
• Identity: 476/1370 - (34%)
• Similarity: 738/1370 - (53%)
• Gaps: 172/1370 - (12%)

  Fly    13 PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSL-------GDRLCA------- 63
            |...||.||.:.|.:...::|:|.|:.|:.:|::...|...::.:       .::.|.
 Frog   207 PVSESSFLSKVTFSWFTEIMFRGYKQPLKAEDVWSLRKSDTAEEILTLFSKGVEKECKKANLLKE 271

  Fly    64 ------------AWDEQVAKNETPRL---------GRALTKV----FGFHLFITGV-------FL 96
                        .|..|..|:|...|         .:.|.||    ||.:..::.:       ||
 Frog   272 PTRFSPSTLDNDMWISQTEKSEIELLLKNQHIQLSQKTLLKVIMRSFGLYFLLSALLMTFYTAFL 336

  Fly    97 LAQEFLTKVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLGL-LH----- 155
            .....|.::     |:.::     .||   .|..|...|:|..:| :|   |....| ||
 Frog   337 FISPLLVRL-----LLQLL-----KDP---SAPSWQGFLVAVFLF-IC---PCCQSLFLHQHDYI 384

  Fly   156 ---LGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELI 217
               :||::|.|:...:|:|||.:|.....:::.|::|||:|.||.:...:...|:|:|.||:.:|
 Frog   385 CYVIGMRLRAAIVGTVYKKALMISSAGRKESSAGEIVNLISTDVQKLMDLATCVNYMWSAPVTII 449

  Fly   218 AVTYLMYLEIGISSMFGVAIMLLFLPFQSYLG---KRTSVLRLRTALRTDERVRMMNEIISGIQV 279
            ...|.::..:||:.:.|||:.:|.|||.:...   ||....:::   :.|.|:::::||:.||:|
 Frog   450 VAMYFLWQTLGIAVLAGVAVFILNLPFMTVFAVIIKRVQEQQMK---QKDGRIKIISEILQGIKV 511

  Fly   280 IKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILI---SFAMFLSRIFTSSSLIAFVLLG---- 337
            :|:||||..|.|.|...|..|:..:|     .|.|:   :.|:|::..|..|..:..|.|.
 Frog   512 LKLYAWENAFMKKVTEFRLMELKAVK-----TGALLLSGALAVFVASPFWVSLTMFGVFLALDEK 571

  Fly   338 NILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQ 402
            |||:|||||......||||..:.| ||..|:.||:..||::|:..|....|.:
 Frog   572 NILDAEKAFVTIILLNILRIPLRM-FPMAITLFAQSSVSLKRMVKFFSAEELE------------ 623

  Fly   403 KAESPNGDSPKGNGIPENL------IEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGA 461
                     |:...|.::|      |....|  .|.| |..|.|:.||:.:.:..||||:|.||.
 Frog   624 ---------PESVDINDSLSKHAITIRHGTF--TWSS-SEPPCLQSINIGIPQGTLVAVVGQVGC 676

  Fly   462 GKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALE 526
            ||:||:.|:|||:....|.:.:..|.:|..|:.|:...|.::|:|||...:|..|..||:.|||.
 Frog   677 GKTSLLSALLGEMEKVEGQVSLMSSVAYVPQQTWIPNATFKENVLFGRKMEKCWYDQVVQACALL 741

  Fly   527 RDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM- 590
            .|.::|..|:.|.:||:|.:||||||.|||:||||||..|:|||||||||||.|||:|||:|.:
 Frog   742 PDLKILSGGENTEIGEKGVNLSGGQKQRISIARAVYRNCDVYLLDDPLSAVDAHVGQHLFEQVIG 806

  Fly   591 -RGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLL-TAPNKDA--- 650
             .|.|:.:..:||||.:.||.|.|:|::|..||:|.:|||:.:.:....|::.| |...|..
 Frog   807 PSGLLKDKTRVLVTHGVSFLPQMDMIIVMSDGRVSEVGTYNELLQKNGAFSEFLNTYARKSVVFE 871

  Fly   651 EDLDE-----IDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEA-SLQMQE 709
            |..:|     |.||            :..:|    |.|.||::......:|..:..:| .|...:
 Frog   872 ESYEEQTPNSIQGA------------MKMKG----KHSARNDTDNETDDVANEIEADAGKLTEAD 920

  Fly   710 TRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWV-----DKNVDGQTDI 769
            ..:.|::.|.:|.||......|:::...:|.     |:..||....:||:     |..|:|....
 Frog   921 VALTGRVKLSVYLEYCKIMGKWYLLISALFF-----IVQQAASLSYNYWIGLWADDPPVNGTQQH 980

  Fly   770 NTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILN 834
            .:....:|.|..:..|:.:|....|::...:::  |.|||:.:...|.|..:.||...|||.:.|
 Frog   981 TSLRLGVYSFLGVMQALSIFAASSTIIVGGVSV--SRQLHSRLLYSILRCPLSFFERTPSGNLTN 1043

  Fly   835 RFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRD 899
            ||:|::..:|..:|.|::..:.:.||:..|::||.|..|...:..:.|.:::::::.||:.:||.
 Frog  1044 RFAKEMDIIDNTVPQVLMLFIIMMLTIAEILLVISIATPLAAVAFIPLGLLYFFLQRFYVASSRQ 1108

  Fly   900 VKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLD 964
            :|||:||::||:|:|.:.::.|:..|||...|:..|.:.:...:::...|:.....||......|
 Frog  1109 LKRLDAVSKSPLYTHFNESLQGVYVIRAFREQERFIQDNNMRLNMNQRFYFCSFVANRWLSVRCD 1173

  Fly   965 CFCTLYIV--IIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYD 1027
             |.:.:||  :.|:........:||.||||:..::.:||:::.|:..:.::|....:||||.||.
 Frog  1174 -FLSNFIVFTVAIVGVLFRDNITPGLVGLAVVNSLRLTGVLKEAVHVATDMETNSVSVERVKEYC 1237

  Fly  1028 EIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTG 1092
            :.|||..:.|......| :||.||:|..::..|||.||  ....||.:...|:..||||||||||
 Frog  1238 DAEPEAPWTSDNASDLS-NWPSKGKIEFQNYGLRYRPD--LDLALKNVTASIQQGEKVGIVGRTG 1299

  Fly  1093 AGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYN 1156
            ||||||...||| |....|.|.|||:|.:::||.:|||||:||||:||||||::|.|||||:.|:
 Frog  1300 AGKSSLTLGLFRILEPATGRICIDEKDISELGLHELRSKITIIPQDPVLFSGTLRMNLDPFDNYS 1364

  Fly  1157 DAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANV 1221
            |..:|.||:...||...|.||.||....:|||.|.|||||||||||||:||:.::||:|||||.|
 Frog  1365 DNDIWVALQLAHLKVFASGLPEGLSYICTEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAV 1429

  Fly  1222 DPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESK-IFH 1285
            |.:||.|||.|||.:|.|||::|||||||||||..||:|.|.|.:|||.:|..||   |:| :|:
 Frog  1430 DLETDDLIQNTIRKEFEDCTIITIAHRLNTIMDYTRVVVFDKGEIVEFDTPATLL---ENKGLFY 1491

  Fly  1286 GMVME 1290
            .|..:
 Frog  1492 SMARD 1496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	471/1354 (35%)
		ABC_membrane	93..359	CDD:294371	88/291 (30%)
		ABCC_MRP_domain1	422..622	CDD:213217	94/201 (47%)
		ABC_membrane	735..978	CDD:294371	67/249 (27%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	130/221 (59%)
abcc6	XP_002932264.3	MRP_assoc_pro	5..1499	CDD:188098	476/1370 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010