Protein Alignment Mrp4 and abcc4

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_002939329.2
• Gene: abcc4 / 100491006
• XenbaseID: XB-GENE-957302
• Length: 1324
• Species: Xenopus tropicalis
• Alignment Length: 1339
• Identity: 589/1339 - (43%)
• Similarity: 850/1339 - (63%)
• Gaps: 87/1339 - (6%)

  Fly    12 NPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDE--QVAKNE- 73
            ||.:.::..|.:.|.:..|:...|.|:.||:.|:|..|.|..|..||:.|...|::  |.|:||
 Frog    11 NPSQHANFCSKIFFWWLNPLFILGHKRKLEEDDMYEVLPEDASRKLGEELQWYWEKELQKAQNEG 75

  Fly    74 -TPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRS----KAQLWAA 133
             .|||.:|:.:.......:.|:|...:|.: :|.|||.|..|::||...|.:.|    .|.:.||
 Frog    76 RKPRLTKAIIRCHWKTFSVLGLFTFFEESI-RVVQPIFLGNVISYFERYDANDSAVLANAYINAA 139

  Fly   134 GLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGR 198
            .|.|.::....:.|.|...||..|||:|:|:..:|||||||||.||:|.||.||:||||||||.:
 Frog   140 ALSACTLILAVVHHIYFYHLLRAGMKLRVAMCHMIYRKALRLSNTAMGKTTTGQIVNLLSNDVNK 204

  Fly   199 FDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRT 263
            ||.|.|.:|:||..||:.||||.|:::|||.|.:.|:|::::.:|.|..|||..:.||.:||..|
 Frog   205 FDQVTIFLHFLWAGPLQAIAVTVLLWMEIGPSCLAGMAVLIILMPLQLCLGKFFTSLRGKTAAFT 269

  Fly   264 DERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSRIFTSS 328
            |.|:|.|||:|||:::|||||||:.|.::|...|..|:..:.:.:|:|.:.::.....|:|....
 Frog   270 DTRIRTMNEVISGMRIIKMYAWEQSFTELVNNIRKKEINKVLRSSYLRALNLASFFVASKIILFV 334

  Fly   329 SLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRD 393
            :...:|||||:::|.:.|...:.|:.:|.:||:|||..:...:|..||:||::.|:...|
 Frog   335 TFTTYVLLGNVISASRVFVAVSLYSAVRLTVTLFFPSAVERASEAKVSIRRIKNFLLLDE----- 394

  Fly   394 KSKVKNANQKAESPNGDSPKGNGIPEN-LIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIG 457
                      ...|..:.|:.|  .|| |::.......|:.....|||::|:..:...:|:||||
 Frog   395 ----------IFKPALELPEEN--EENLLVQIQDVTCYWDKTLEIPTLQNISCSVRPGELLAVIG 447

  Fly   458 PVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKK 522
            |||||||||:.|:|||||.:.|.:.|.|..:|.:|:||:|:||||.|||||.::.:.:|..|::.
 Frog   448 PVGAGKSSLLSAVLGELPKDKGFVDIRGRIAYVSQQPWVFSGTVRSNILFGKEYVQEKYDKVLRV 512

  Fly   523 CALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFD 587
            |||::|...|..||.||:|:||.:||||||||::||||||:.||||||||||||||..||||||:
 Frog   513 CALKKDMLQLDDGDLTIIGDRGVTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVGRHLFE 577

  Fly   588 QCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAED 652
            :|:...||.:|.||||||||:|..|..|:|:.:||:...||:..:.:||:|||.||.:..::
 Frog   578 KCICQALRKKLCILVTHQLQYLSAAKQILILKEGRMVGKGTFQELLQSGIDFASLLKSEEEE--- 639

  Fly   653 LDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLS-------------SMAESMAQEAS 704
                             .|.|:.|....  |:||.:|:..|             ...:::|.|..
 Frog   640 -----------------QSQSQEGQLIK--SSRNRTFSQSSVWSQDSTVQSHKEGATDNLAAEPV 685

  Fly   705 LQM--QETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQT 767
            |..  :|:|.||.:|..:||:|.|||||:.|:|.::.|.:.:|:.....|::||||.  |..|:.
 Frog   686 LTAIPEESRSEGTVGFKVYKKYFTSGSSYLMLFVVLLLNILSQVTYVLQDWWLSYWA--NEQGKL 748

  Fly   768 DI---------NTDPQDMY----YFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRA 819
            :|         .|:..|:.    .:|.|.||.::|.::|.:|.:.:.:.::..|||.|:|.:.:|
 Frog   749 NITSGTNSTGSKTEQLDLTLYLGVYAGLTVATIIFGVLRCLLVFHVLVCAAQALHNQMFQSLLKA 813

  Fly   820 AMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAI 884
            .:.||:.||.||||||||||:|.||:::|...||.:|:.|.:||:|.|.....|:.||..|.|.|
 Frog   814 PVLFFDRNPIGRILNRFSKDIGHLDDLMPFTFLDFMQVLLQILGVIAVAVAVIPWILIPLLPLVI 878

  Fly   885 IFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGY 949
            :||::|.::|.||||:||||:..|||::||||:::.||.||||..|:|.....||..|||||..:
 Frog   879 VFYFLRRYFLDTSRDIKRLESTTRSPVFSHLSSSLQGLWTIRAFKAEKRFQDLFDAQQDLHSEAW 943

  Fly   950 YTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQ-SPGEVGLAITQAMGMTGMVQWAMRQSAEL 1013
            :.||.|:|.....||..|.::::.|.....|.... ..|:||||::..|.:.|..||.:|||||:
 Frog   944 FLFLTTSRWLAVRLDAICAVFVIAIAFGSIILAENLDAGQVGLALSYGMTIMGSFQWGVRQSAEV 1008

  Fly  1014 ENTMTAVERVVEYDEIEPEGEFDSREGKKPSPS-WPEKGEIIAEDLCLRYFPDPQAKYVLKALNF 1077
            ||.|.:.|||:||.::|.|.|::|   |.|.|: ||.||.|..|::...|..|  ...||:.||.
 Frog  1009 ENLMISAERVMEYTQLEKEAEWES---KNPPPADWPNKGMITFENVNFSYSLD--GPVVLRHLNA 1068

  Fly  1078 RIRPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFS 1142
            .|||.|||||||||||||||||.|||||:..||.|.||:..|:.:||.|||.|:||||||||||:
 Frog  1069 LIRPKEKVGIVGRTGAGKSSLIAALFRLAEPEGKIWIDKYLTSKLGLHDLRKKMSIIPQEPVLFT 1133

  Fly  1143 GSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILR 1207
            |:||.|||||:|:.|.:|||.||||:||..:.|||..:::::||.||||||||||||||||||||
 Frog  1134 GTMRKNLDPFDEHADEELWDVLEEVQLKEAVEELPGKIETQLSESGSNFSVGQRQLVCLARAILR 1198

  Fly  1208 ENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSP 1272
            .||:|::|||||||||:||.|||.|||.||.:|||||||||||||:|||:::|:|||.:.|:..|
 Frog  1199 RNRILIIDEATANVDPRTDELIQKTIREKFAECTVLTIAHRLNTIIDSDKIMVLDAGRVKEYDEP 1263

  Fly  1273 YELLTSSESKIFHGMVMETGQNTFDSLLKVAEKAHLESM 1311
            |.||.:.|| :|:.||.:.|:....:|.:.|::.:|:.:
 Frog  1264 YLLLQNKES-LFYKMVQQVGKAEATALNEAAKQVYLKKI 1301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	579/1303 (44%)
		ABC_membrane	93..359	CDD:294371	114/269 (42%)
		ABCC_MRP_domain1	422..622	CDD:213217	106/199 (53%)
		ABC_membrane	735..978	CDD:294371	100/255 (39%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	143/220 (65%)
abcc4	XP_002939329.2	PLN03130	2..1289	CDD:215595	586/1325 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I2471
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1027	1.000	Inparanoid score	I277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm47437
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160