DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and abcb4

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	NP_001303643.1	Gene:	abcb4 / 100136865	ZFINID:	ZDB-GENE-080204-52	Length:	1275	Species:	Danio rerio

Alignment Length:	1206	Identity:	284/1206 - (23%)
Similarity:	515/1206 - (42%)	Gaps:	213/1206 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 GQVVNLLSNDV--------GRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFL 242
            ||:...|::||        .:..:::.|:            .|:::.:.||.:.  |..:.|:.|
Zfish   174 GQLNTRLTDDVYKINEGIGDKLGMLIQNL------------TTFIVGIIIGFAK--GWKLTLVIL 224

  Fly   243 PFQSYLGKRTSVL-RLRTALRTDERV------RMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNE 300
            .....||...:|: ::.|...:.|:.      .:..|::|.|:.:..:..:|.     |:.|:::
Zfish   225 AVSPLLGISAAVIGKVMTTFTSKEQTAYAKAGAVAEEVLSSIRTVFAFGGQKK-----EIKRYHK 284

  Fly   301 ML-CIKQVNYIRGILISFAM-FLSRIFTSSSLIAF-----VLLGNILNAEKAFFVTAYYNILRRS 358
            .| ..|.|...:.|.::.|| |...:...|..:||     ::||.....  ...:|.::.:|
Zfish   285 NLEDAKNVGVRKAITVNIAMGFTFFMIYMSYALAFWYGSTLILGGEYTI--GMLLTIFFAVL--- 344

  Fly   359 VTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIE 423
            :..|   |:.:.:..:.:........|:....:..:.|:.:.::  |....|..|||      ||
Zfish   345 IGAF---GLGQTSPNIQTFSSARGAAHKVFQIIDHEPKINSFSE--EGYKLDVVKGN------IE 398

  Fly   424 FSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGS-- 486
            |.....|:.|......|..:||::...:.:|::|..|.|||:.||.:......:.|::.|:|.
Zfish   399 FKNIHFRYPSRDDVKVLNGMNLKVMSGQTIALVGSSGCGKSTTIQLLQRFYDPQEGSVSIDGHDI 463

  Fly   487 -----------YSYAAQEPWLFTGTVRQNILFGLD-----------WDKHRYRTVVKKCALERDF 529
                       ....:|||.||..|:.:||.:|..           .:.:.|..::|
Zfish   464 RSLNVRGLRELIGVVSQEPVLFATTIAENIRYGRQDVTQDEIEQAAREANAYNFIMK-------- 520

  Fly   530 ELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTH---VGRHLFDQCMR 591
              ||...:|:||:||..:|||||.||::|||:.|...|.|||:..||:|..   :.:...|:...
Zfish   521 --LPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRL 583

  Fly   592 GYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSS-MKRSGLDFA----QLLTAPNKDAE 651
            |    ...|:|.|:|..:..||:|.....|.|..:||:.. |:|.|:..:    |:..:.....|
Zfish   584 G----RTTIVVAHRLSTIRNADVIAGFQNGEIVELGTHDELMERKGIYHSLVNMQMFKSTEVAEE 644

  Fly   652 DLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKI 716
            |.:|:.      :|..: ||:|   |.|.:...|..|    .|.:|...:|.....:|.:|....
Zfish   645 DSEEMT------MDEKS-PSVS---SMNERTLFRQKS----RSGSEKELKEEEKPTEEEKVPNVS 695

  Fly   717 GLGLYKEYLTSGSSW-FMIFFMV-----------FLCLATQILCSAADYFLSYWVDKNVDGQTDI 769
            .|.:.|   .:...| :|:..::           |..:.::|:...|:      .|:|:..|.
Zfish   696 FLTVLK---LNYPEWPYMVVGILCATINGGMQPAFAVIFSKIIAVFAE------PDQNLVRQR-- 749

  Fly   770 NTDPQDMY--YFAALNVAVVVFTIVRTMLFYK----MAMRSSTQLHNAMYQGITRAAMYFFNTNP 828
                .|:|  .||.:.|.......::...|.|    :.||...:..|||.:  ...|.|....|.
Zfish   750 ----CDLYSLLFAGIGVLSFFTLFLQGFCFGKAGELLTMRLRFKAFNAMMR--QDLAWYDDTKNS 808

  Fly   829 SGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYL---------ILTLALAI 884
            .|.:..|.:.|..|: :....|.|..:...:..||..:||.....:.|         |:.:|.||
Zfish   809 VGALTTRLAADTAQV-QGATGVRLATLAQNVANLGTAIVISFVYGWQLTLLILSIVPIMAVAGAI 872

  Fly   885 IFYYIREFYLKTSRDVKRLEAVARSPIYS-HLSATITGLPTIRALGAQKELIAEFDNL-QDLHSS 947
            ....:....||..:::::...:|...|.: ....::|......:| .::.||..:.|. :..|..
Zfish   873 QMKLLAGHALKDKKELEQAGKIATEAIENVRTVVSLTRESKFESL-YEENLIVPYKNAKKKAHVF 936

  Fly   948 GYYTFLATNRAFGY--YLDCF-----------CTLYIVIIILNYFINPPQSPGEVGLAITQAMGM 999
            | .|| :.::|..|  |..||           .|...|.::::..:....:.||.. :.|.....
Zfish   937 G-LTF-SFSQAMIYFAYAGCFKFGSWLIEQKLMTFEGVFLVISAVVYGAMAVGEAN-SFTPNYAK 998

  Fly  1000 TGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFP 1064
            ..|         ...:.:..:.|....|.       .|.:|.||...   :|.:..|.:..:|..
Zfish   999 AKM---------SASHVLMLINRAPAIDN-------SSEDGDKPDKF---EGNVGFEHVYFKYPS 1044

  Fly  1065 DPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYN--EGIITIDERDTADMGLFDL 1127
            .|... ||:.|..|::..:.:.:||.:|.|||:.|..|.|. |:  :|.:.:|:.|...:.:..|
Zfish  1045 RPDVP-VLQGLKLRVKKGQTLALVGSSGCGKSTTIQLLERF-YDPQQGRVMLDDNDAKQLNIHWL 1107

  Fly  1128 RSKISIIPQEPVLFSGSMRYNL---DPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGS 1189
            ||:|.|:.||||||..|:..|:   |...|.:..::.:|.:...:...|..||...|::..:.|:
Zfish  1108 RSQIGIVSQEPVLFDCSLAENIAYGDNSREVDQEEIVEAAKAANIHSFIENLPQRYQTQAGDKGT 1172

  Fly  1190 NFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQATI--RSKFRDCTVLTIAHRLNTI 1252
            ..|.||:|.:.:||||||..:||::||||:.:|.:::.::|..:  .||.|.|.:  :||||:||
Zfish  1173 QLSGGQKQRIAIARAILRNPKVLLLDEATSALDTESEKIVQDALDKASKGRTCII--VAHRLSTI 1235

  Fly  1253 MDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMV 1288
            .::|.:.|:..|.:||.|:..:||  |:...::.:|
Zfish  1236 QNADCIAVVQNGVVVEQGTHQQLL--SQQGAYYTLV 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	281/1193 (24%)
		ABC_membrane	93..359	CDD:294371	37/194 (19%)
		ABCC_MRP_domain1	422..622	CDD:213217	64/226 (28%)
		ABC_membrane	735..978	CDD:294371	56/283 (20%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	76/227 (33%)
abcb4	NP_001303643.1	PTZ00265	55..1266	CDD:240339	283/1201 (24%)
		ABC_membrane	60..348	CDD:279056	37/197 (19%)
		ABC_MTABC3_MDL1_MDL2	397..634	CDD:213216	71/250 (28%)
		ABC_membrane	714..984	CDD:279056	56/287 (20%)
		ABC_MTABC3_MDL1_MDL2	1035..1272	CDD:213216	79/241 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000