DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mrp4 and abcc3

DIOPT Version :9

Sequence 1:NP_650086.2 Gene:Mrp4 / 41387 FlyBaseID:FBgn0263316 Length:1316 Species:Drosophila melanogaster
Sequence 2:NP_001107301.1 Gene:abcc3 / 100135090 XenbaseID:XB-GENE-1003737 Length:1531 Species:Xenopus tropicalis


Alignment Length:1370 Identity:493/1370 - (35%)
Similarity:745/1370 - (54%) Gaps:126/1370 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 DELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVA- 70
            ||:...|...:..||.|.|.:...:...|.|:.||.|||:...::..|:.:...|...|:::.: 
 Frog   202 DEINPCPESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIKEWEKEKSN 266

  Fly    71 ----------------------------------KNETPRLGRALTKVFGFHLFITGVFLLAQEF 101
                                              |.:.|...:.|.:.||.:..|...|.|.|:.
 Frog   267 LAQMQVSYSKKPEAVLNHTDEKAYESDVLIVDNKKPKEPSFLKVLLRTFGPYFLIGSFFKLFQDL 331

  Fly   102 LTKVTQPICLIGVMAYFAGNDPDRSKAQLW-----AAGLIAGSVFSVCIGHPYMLGLLHLGMKMR 161
            |:.|...  |:.::..|..|    ..|..|     |..:...|:....|.|.:.......||::|
 Frog   332 LSFVNPQ--LLSILITFIKN----KDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVTGMRLR 390

  Fly   162 IALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLE 226
            .|::.:||||:|.::.:|...:|||:||||:|.|..||..:...::.||.|||::....|.::..
 Frog   391 SAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQA 455

  Fly   227 IGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGK 291
            :|.|.:.|||:|:|.:|..:::..:|...::......|.|:::||||::||:|:|:||||..|.:
 Frog   456 LGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQ 520

  Fly   292 VVEMTRFNEMLCIKQVNYIRGILISFAM----FLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYY 352
            .|...|..|:..:|:..|:.. |.:||.    ||..: |:.::...|...|||:|||||...:.:
 Frog   521 KVLEIRNKELNILKKAAYLNA-LSTFAWTSAPFLVAL-TTFAVYVTVDEKNILDAEKAFVSLSLF 583

  Fly   353 NILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGI 417
            ||||..:.| .||.||..|:..||::|::.|:...|..:...:|.|.                 :
 Frog   584 NILRFPLNM-LPQVISNLAQASVSIKRIQNFLANDELDLNAVTKDKT-----------------L 630

  Fly   418 PENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLR 482
            |.|.|........|..:. ...|::|||.:....||||:|.||.|||||:.|:|||:..|.|.:.
 Frog   631 PGNAITVHNGTFSWAKNG-GAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVS 694

  Fly   483 INGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASL 547
            :.||.:|..|:.|:...|::.|||||...::..|:.|::.|||..|.|:||.||:|.:||:|.:|
 Frog   695 VRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINL 759

  Fly   548 SGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSELVILVTHQLQFLE 610
            |||||.|:||||||:..||:|||||||||||.||.:|:||..:  .|.||.:..:||||.:.||.
 Frog   760 SGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLP 824

  Fly   611 QADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLL-------- 667
            |.|.||::..||::.||:|..:.:....|::.|.....| ::::|.|....|..::|        
 Frog   825 QVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFD-DEVEEEDITIPDEEEVLLAEETLST 888

  Fly   668 ------NVP-------------SLSRRGSKNSKPSTRNNSFTSLSSMAESMAQE---ASLQMQET 710
                  |.|             |:...|..:...|||.. ||........:|::   ..|...||
 Frog   889 HTDLADNEPVANEARKKFIRQISILSDGEPSHAMSTRRR-FTEKKPSENLVAKQPPTEKLIQTET 952

  Fly   711 RVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQD 775
            ...|::.:.::.:|:.:......: |:.||..........|:.:||.|.::.|..||..||..: 
 Frog   953 TETGRVKMTVFWQYMKAVGLAISV-FICFLYSCQNAAAIGANVWLSDWTNEPVINQTQQNTQMR- 1015

  Fly   776 MYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDL 840
            :..:|||.:...:..:..:.......:.::.:||:|:..........|::|.|.|||:||||||:
 Frog  1016 VGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDI 1080

  Fly   841 GQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEA 905
            ..:|||:|..:|..:..|.|.|..::||..:.|.:.::.:.|||.:.:::.||:.|||.:||||:
 Frog  1081 YVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQRFYVATSRQLKRLES 1145

  Fly   906 VARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLD----C- 965
            |:|||||||.|.||||...|||.|.|...|...||..|.:...||..:.:||..|..::    | 
 Frog  1146 VSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEFVGNCV 1210

  Fly   966 --FCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDE 1028
              |..|:.|:      .....|||.|||:::.|:.:|..:.|.:|.:::||..:.|||||.||.|
 Frog  1211 VLFAALFAVL------GREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAE 1269

  Fly  1029 IEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGA 1093
            .|.|..:.. |..||...||.|||:...:..:||  ......|||.||.::...|||||||||||
 Frog  1270 NETEAPWHI-EDTKPPEDWPSKGEVELSNYSVRY--RAGLDLVLKNLNLKVNGGEKVGIVGRTGA 1331

  Fly  1094 GKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYND 1157
            ||||:...||| |...|||:.||..:.:::||.||||:::||||:||||||::|.|||||.:|:|
 Frog  1332 GKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSD 1396

  Fly  1158 AKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVD 1222
            .::|.|||...||..::..|:.|:.:.||||.|.|||||||||||||:||:.|:|::|||||.:|
 Frog  1397 DEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSVGQRQLVCLARALLRKTRILILDEATAAID 1461

  Fly  1223 PQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGM 1287
            .:||.|||.|||::|.||||||||||||||||..||||:|.|.:.||.:|..|:  :...||:||
 Frog  1462 LETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLI--ALKGIFYGM 1524

  Fly  1288 VMETG 1292
            ..:.|
 Frog  1525 AKDAG 1529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mrp4NP_650086.2 CFTR_protein 12..1277 CDD:273530 486/1348 (36%)
ABC_membrane 93..359 CDD:294371 89/274 (32%)
ABCC_MRP_domain1 422..622 CDD:213217 94/201 (47%)
ABC_membrane 735..978 CDD:294371 84/249 (34%)
ABCC_MRP_domain2 1051..1272 CDD:213211 126/221 (57%)
abcc3NP_001107301.1 MRP_assoc_pro 7..1530 CDD:188098 493/1370 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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