Protein Alignment Mrp4 and abcc3

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: NP_001107301.1
• Gene: abcc3 / 100135090
• XenbaseID: XB-GENE-1003737
• Length: 1531
• Species: Xenopus tropicalis
• Alignment Length: 1370
• Identity: 493/1370 - (35%)
• Similarity: 745/1370 - (54%)
• Gaps: 126/1370 - (9%)

  Fly     7 DELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQVA- 70
            ||:...|...:..||.|.|.:...:...|.|:.||.|||:...::..|:.:...|...|:::.:
 Frog   202 DEINPCPESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIKEWEKEKSN 266

  Fly    71 ----------------------------------KNETPRLGRALTKVFGFHLFITGVFLLAQEF 101
                                              |.:.|...:.|.:.||.:..|...|.|.|:.
 Frog   267 LAQMQVSYSKKPEAVLNHTDEKAYESDVLIVDNKKPKEPSFLKVLLRTFGPYFLIGSFFKLFQDL 331

  Fly   102 LTKVTQPICLIGVMAYFAGNDPDRSKAQLW-----AAGLIAGSVFSVCIGHPYMLGLLHLGMKMR 161
            |:.|...  |:.::..|..|    ..|..|     |..:...|:....|.|.:.......||::|
 Frog   332 LSFVNPQ--LLSILITFIKN----KDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVTGMRLR 390

  Fly   162 IALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLE 226
            .|::.:||||:|.::.:|...:|||:||||:|.|..||..:...::.||.|||::....|.::..
 Frog   391 SAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLTTFLNMLWSAPLQICLALYFLWQA 455

  Fly   227 IGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGK 291
            :|.|.:.|||:|:|.:|..:::..:|...::......|.|:::||||::||:|:|:||||..|.:
 Frog   456 LGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAWEPSFAQ 520

  Fly   292 VVEMTRFNEMLCIKQVNYIRGILISFAM----FLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYY 352
            .|...|..|:..:|:..|:.. |.:||.    ||..: |:.::...|...|||:|||||...:.:
 Frog   521 KVLEIRNKELNILKKAAYLNA-LSTFAWTSAPFLVAL-TTFAVYVTVDEKNILDAEKAFVSLSLF 583

  Fly   353 NILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGI 417
            ||||..:.| .||.||..|:..||::|::.|:...|..:...:|.|.                 :
 Frog   584 NILRFPLNM-LPQVISNLAQASVSIKRIQNFLANDELDLNAVTKDKT-----------------L 630

  Fly   418 PENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLR 482
            |.|.|........|..:. ...|::|||.:....||||:|.||.|||||:.|:|||:..|.|.:.
 Frog   631 PGNAITVHNGTFSWAKNG-GAILQNINLLVPSGSLVAVVGQVGCGKSSLVSALLGEMEKEEGEVS 694

  Fly   483 INGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASL 547
            :.||.:|..|:.|:...|::.|||||...::..|:.|::.|||..|.|:||.||:|.:||:|.:|
 Frog   695 VRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVTDLEVLPGGDQTEIGEKGINL 759

  Fly   548 SGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSELVILVTHQLQFLE 610
            |||||.|:||||||:..||:|||||||||||.||.:|:||..:  .|.||.:..:||||.:.||.
 Frog   760 SGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGPDGLLRGKTRVLVTHGISFLP 824

  Fly   611 QADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLL-------- 667
            |.|.||::..||::.||:|..:.:....|::.|.....| ::::|.|....|..::|
 Frog   825 QVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFD-DEVEEEDITIPDEEEVLLAEETLST 888

  Fly   668 ------NVP-------------SLSRRGSKNSKPSTRNNSFTSLSSMAESMAQE---ASLQMQET 710
                  |.|             |:...|..:...|||.. ||........:|::   ..|...||
 Frog   889 HTDLADNEPVANEARKKFIRQISILSDGEPSHAMSTRRR-FTEKKPSENLVAKQPPTEKLIQTET 952

  Fly   711 RVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQD 775
            ...|::.:.::.:|:.:......: |:.||..........|:.:||.|.::.|..||..||..:
 Frog   953 TETGRVKMTVFWQYMKAVGLAISV-FICFLYSCQNAAAIGANVWLSDWTNEPVINQTQQNTQMR- 1015

  Fly   776 MYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDL 840
            :..:|||.:...:..:..:.......:.::.:||:|:..........|::|.|.|||:||||||:
 Frog  1016 VGVYAALGILQGLLVMTSSFSLAIAGIGAARKLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDI 1080

  Fly   841 GQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEA 905
            ..:|||:|..:|..:..|.|.|..::||..:.|.:.::.:.|||.:.:::.||:.|||.:||||:
 Frog  1081 YVIDEVIPGTILMFLATFFTSLSTMIVIVASTPLFAVVIIPLAIAYIFVQRFYVATSRQLKRLES 1145

  Fly   906 VARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLD----C- 965
            |:|||||||.|.||||...|||.|.|...|...||..|.:...||..:.:||..|..::    |
 Frog  1146 VSRSPIYSHFSETITGASIIRAYGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEFVGNCV 1210

  Fly   966 --FCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDE 1028
              |..|:.|:      .....|||.|||:::.|:.:|..:.|.:|.:::||..:.|||||.||.|
 Frog  1211 VLFAALFAVL------GREHLSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAE 1269

  Fly  1029 IEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGA 1093
            .|.|..:.. |..||...||.|||:...:..:||  ......|||.||.::...|||||||||||
 Frog  1270 NETEAPWHI-EDTKPPEDWPSKGEVELSNYSVRY--RAGLDLVLKNLNLKVNGGEKVGIVGRTGA 1331

  Fly  1094 GKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYND 1157
            ||||:...||| |...|||:.||..:.:::||.||||:::||||:||||||::|.|||||.:|:|
 Frog  1332 GKSSMTLCLFRILEPAEGIVKIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSD 1396

  Fly  1158 AKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVD 1222
            .::|.|||...||..::..|:.|:.:.||||.|.|||||||||||||:||:.|:|::|||||.:|
 Frog  1397 DEIWKALELSNLKKFVAGQPSQLEYECSEGGENLSVGQRQLVCLARALLRKTRILILDEATAAID 1461

  Fly  1223 PQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGM 1287
            .:||.|||.|||::|.||||||||||||||||..||||:|.|.:.||.:|..|:  :...||:||
 Frog  1462 LETDDLIQMTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLI--ALKGIFYGM 1524

  Fly  1288 VMETG 1292
            ..:.|
 Frog  1525 AKDAG 1529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	490/1362 (36%)
abcc3	NP_001107301.1	MRP_assoc_pro	7..1530	CDD:188098	493/1370 (36%)