Protein Alignment Mrp4 and abcc5

DIOPT Version :9

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_012818083.1
• Gene: abcc5 / 100125060
• XenbaseID: XB-GENE-986260
• Length: 1437
• Species: Xenopus tropicalis
• Alignment Length: 1380
• Identity: 441/1380 - (31%)
• Similarity: 731/1380 - (52%)
• Gaps: 161/1380 - (11%)

  Fly    11 ENPRERSSPLSSLMFCFALPVLFKGRKK-TLEQKDLYRALKEHKSDSLGDRLCAAWDEQVAKNET 74
            ::|.:.:...|.:.|.:..|:.....|| .|..:|::...|...||....||...|.|:|.:...
 Frog    99 QHPVDNAGLFSFMTFSWLTPMARIAYKKGELFFEDIWPLSKHESSDINSKRLEKLWLEEVTEKGA 163

  Fly    75 PR-------------------LGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAG 120
            ..                   :...||::.|   ||...|::  :.|.:.||.          :.
 Frog   164 DESSLRSVVWHFCRTRLIISIMCLMLTQLAG---FIGPAFVV--KSLLEYTQQ----------SS 213

  Fly   121 NDPDRSKAQLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTV 185
            .||..|...::|. |:...|.|..:...:.|. ...|.::|.|:.::.::|.|:|..  :.:.::
 Frog   214 KDPGYSLLLVFAL-LMTEIVRSWSLALTWALN-YRTGSRLRGAVLTMAFKKILKLKN--IKEKSM 274

  Fly   186 GQVVNLLSNDVGR-FDLVLINVHYLWIAPLELIAVTYLMY--LEIGISSMFGVAIMLLFLPFQSY 247
            |:::|:.|:|..| |:...:.   ..:|...::|:..::|  :.:|.:...|.|:.:||.|...:
 Frog   275 GELINVCSSDGQRMFEAAAVG---SLLAGGPIVAILGMIYNVIILGPTGFLGSAVFILFYPAMMF 336

  Fly   248 LGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRG 312
            :.:.|:..|.:....|||||:.|||:::.|:.||||||.|.|.:.|:..|.||...:::..|.:.
 Frog   337 VSRLTAYFRRKCVSVTDERVQKMNEVLNYIKFIKMYAWVKAFSQNVQKIRENERSILERAGYFQS 401

  Fly   313 ILISFAMFLSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSV 377
            |.:..|..:..|.:..:....::||..|.|.:||.|...:|.:..::.: .|..:...:|..||:
 Frog   402 ITVGIAPIVVVIASVLTFSVHMILGYDLTAAQAFTVVTVFNSMTFALKV-TPFSVKSLSEASVSM 465

  Fly   378 RRLEAFMHRPETKVRDKS--------KVKNANQKAESPNGD---SPKG--------NGIP----- 418
            .|.::.....|..:..|.        ::|||....::....   ||||        .|:.
 Frog   466 DRFKSLFLMEEVHMVKKKPSSPNLIIELKNATLAWDTTYASTQCSPKGTPKLKKGKKGVKGKKEK 530

  Fly   419 -ENLIEFSQ-FQARWESH-----------------------SLEPTLEDINLQLGRRKLVAVIGP 458
             .:.||.|| ..|..:.|                       .|:..|..|:|.:.:.||:.:.|.
 Frog   531 CSHEIEGSQAVLAEQKGHLLIDSDEHPSPDEETKELPVINVKLQRALYSIDLDIEKGKLIGICGS 595

  Fly   459 VGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKC 523
            ||:||:|||.||||::....|::.::||::|.||:.|:...|:|.|||||.::|:..|..|:..|
 Frog   596 VGSGKTSLISAILGQMTLLEGSIAVSGSFAYVAQQAWILNATLRDNILFGKEFDEEEYNAVLNVC 660

  Fly   524 ALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQ 588
            .|..|..:||.||.|.:|||||:|||||:.|||||||:|....||:|||||||:|.|||.|:|:.
 Frog   661 CLRPDLAILPNGDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNS 725

  Fly   589 CMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFA------QLLTAPN 647
            .:|.:|:|:.::.:|||||:|...|.::.|.:|.|:..||:..:.:...::|      ||..||:
 Frog   726 AIRKHLKSKTILFITHQLQYLVDCDDVIYMKEGCITERGTHEDLIKLNGEYAAIFNNFQLGDAPH 790

  Fly   648 KDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNS--KPSTRNNSFTSLSSMAESMAQEASLQMQET 710
                            ::.:|:    ::..|||  ||..:.|...|:........:|..|...|.
 Frog   791 ----------------IEQMNL----KKNLKNSLKKPLEKGNKAGSVKKEKTVKKEEGQLMQLEE 835

  Fly   711 RVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAA--DYFLSYWVDKNVDGQTDI---- 769
            :.:|.:...:|..|:.|....|.  |::.:.|....:.|.|  :::||||: |...|.|.:
 Frog   836 KGKGSVPWSVYGAYIQSAGGPFA--FLIIMTLFVLNVGSTAFSNWWLSYWI-KQGSGNTTVVVHN 897

  Fly   770 --------NTDPQDMYYFAALNVAVVVFTI---VRTMLFYKMAMRSSTQLHNAMYQGITRAAMYF 823
                    ..:|..::|.|...:::||..:   ||.::|.|..:|:|::||:.:::.|.|:.|.|
 Frog   898 ETVVSNSMKDNPHVLFYTAIYALSMVVMLLLKAVRGIVFVKGTLRASSRLHDELFRRILRSPMKF 962

  Fly   824 FNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYY 888
            |:|.|:||:|||||||:.::|..||......||..:.:...:.||....|::|:....|.::|..
 Frog   963 FDTTPTGRVLNRFSKDMDEVDVRLPFQAEMFVQNVILVFFCLGVISFVFPWFLVAVGPLVVLFTI 1027

  Fly   889 IREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFL 953
            :........|::||||.:.:||..||::::|.||.||.|.....|.:..:..|.|.:.:.:|.|.
 Frog  1028 LHVVSRVFIRELKRLENITQSPFLSHITSSIQGLTTIHAYSKGNEFLLRYQELLDNNQAPFYLFN 1092

  Fly   954 ATNRAFGYYLD-----CFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAEL 1013
            ...|.....||     ...|..::|::::..|    ||...|||::.|:.:||:.|:.:|.::|.
 Frog  1093 CAMRWLAIRLDVISVSLITTTGLMIVLMHGNI----SPAYAGLAMSYAVQLTGLFQFTVRLASET 1153

  Fly  1014 ENTMTAVERVVEYDE---IEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKAL 1075
            |...|:|||:..|.:   :|.....   :.|.|...||::|||..|:..:||  ......|||.:
 Frog  1154 EARFTSVERINHYIKTLALEAPARI---KNKAPPADWPQEGEIKFENAEMRY--RENLPLVLKKV 1213

  Fly  1076 NFRIRPCEKVGIVGRTGAGKSSLINALFRL-SYNEGIITIDERDTADMGLFDLRSKISIIPQEPV 1139
            :|.|:|.||:|||||||:||:||..||||| ..:.|.|.||....:|:||.|||||:||||||||
 Frog  1214 SFTIKPKEKIGIVGRTGSGKTSLGMALFRLVELSGGCIKIDGVKISDIGLADLRSKLSIIPQEPV 1278

  Fly  1140 LFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARA 1204
            ||||::|.|||||.:|::.::|||||...:|..:::||..|::::.|.|.|||||:|||:|:||.
 Frog  1279 LFSGTVRSNLDPFSQYSEEQIWDALERTHMKECVAQLPLKLETEVLENGENFSVGERQLMCIARV 1343

  Fly  1205 ILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEF 1269
            :||..::|::|||||.:|.:||.|||.|||..|.:||:|||||||:|::..||::|:..|.::|:
 Frog  1344 LLRRCKILILDEATAAMDTETDLLIQETIREAFAECTMLTIAHRLHTVLSCDRIMVLAQGQVMEY 1408

  Fly  1270 GSPYELLTSSESKIF 1284
            .:|..||::..::.|
 Frog  1409 DTPSALLSNENTRFF 1423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	439/1370 (32%)
		ABC_membrane	93..359	CDD:294371	68/268 (25%)
		ABCC_MRP_domain1	422..622	CDD:213217	93/223 (42%)
		ABC_membrane	735..978	CDD:294371	76/264 (29%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	116/221 (52%)
abcc5	XP_012818083.1	PLN03130	101..1425	CDD:215595	441/1378 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930