Protein Alignment Mrp4 and abcc6b.2

DIOPT Version :10

• Sequence 1: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Sequence 2: XP_003198194.2
• Gene: abcc6b.2 / 100002917
• ZFINID: ZDB-GENE-110208-2
• Length: 1502
• Species: Danio rerio
• Alignment Length: 1381
• Identity: 501/1381 - (36%)
• Similarity: 755/1381 - (54%)
• Gaps: 164/1381 - (11%)

  Fly     6 ADELPEN----------PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDR 60
            ||:.|:.          |.|.:|.||.|:|.:...::.||.:..|:.:||:...:|..|:.:...
Zfish   190 ADQRPDTLKPVYVKNPCPVEDASFLSKLLFWWYGRLVVKGYRSPLKAEDLWSLREEDTSEKIICD 254

  Fly    61 LCAAWDEQVAK--------NETPRLG-------------------------RALTKVFGFHLFIT 92
            |...|.:|.||        ||...||                         |.|.|:|..: |:|
Zfish   255 LEKEWAKQWAKLQQKKSSLNEAQTLGFKLSSCVKQLFRKLFKEQCTGFVLFRTLAKIFSPY-FLT 318

  Fly    93 G-VFLLAQEFLT-KVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVFSV-CI----GHPYM 150
            | :||:.|:.|. .:.|.:.|:  :.|....|     |.||...|.|.|:|.: |:    .|.||
Zfish   319 GTLFLVIQDALMFSIPQVLSLL--LGYVRDED-----APLWKGYLFAFSLFLLSCLQSLFNHQYM 376

  Fly   151 LGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLE 215
            ...|.:||:::.|:..|:|||:|.::..|....|||::|||:|.|..:....::..:.||:||:|
Zfish   377 YTCLTVGMRVKTAVMGLVYRKSLVINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIE 441

  Fly   216 LIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVI 280
            :....:.::..:|.|::.|:..::|..|...::.|..|.|:.......|||:::||||:|||:::
Zfish   442 IALCLFFLWQHLGPSTLAGITTVILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKIL 506

  Fly   281 KMYAWEKPFGKVVEMTRFNEMLCIK--QVNYIRGILISFAMFLSRIFTSSSLIAFVLLG------ 337
            |.|||||.|.:.|...|..|:..:|  |:.|    .:|.|.|.|    |:.||||.:.|
Zfish   507 KFYAWEKAFRERVLGYREKELNALKKSQILY----SVSIASFNS----STLLIAFAMFGVYVLID 563

  Fly   338 --NILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNA 400
              ::|:|:|.|...|..|||:..::. .|..:|...:::||::||..|:.:.|.|:....:|
Zfish   564 DKHVLDAQKIFVSMALINILKAPLSQ-LPIAMSTTMQVVVSLKRLGTFLDQDELKLDSVQRV--- 624

  Fly   401 NQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSS 465
                       |....|...:|....|.  |...| .|.|..||:::.|..||||:|.||:||||
Zfish   625 -----------PYNPNIESVVINNGTFS--WSKDS-TPCLRRINVKVQRGSLVAVVGHVGSGKSS 675

  Fly   466 LIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFE 530
            |:.|:|||:..:||.:.|.||..|..|:.|:...|::.|||||.:.....|:.|::.|||..|.|
Zfish   676 LLSAMLGEMEKKSGHITITGSVGYVPQQAWIQNATLKDNILFGCEKKDSLYQKVLEACALLPDLE 740

  Fly   531 LLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGY 593
            :||..|.|.:||:|.:||||||.|:||||||||.:|||||||||||||.|||:|:|::.:  .|.
Zfish   741 ILPARDATEIGEKGLNLSGGQKQRVSLARAVYRNSDIYLLDDPLSAVDAHVGQHIFEKVIGPNGS 805

  Fly   594 LRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPNKDAEDLDEIDG 658
            |:::..:||||.|.||.|||||::|..|.|..||:|          |:||:..|..||
Zfish   806 LKNKTRVLVTHGLSFLPQADLILVMADGEIKEMGSY----------AELLSRKNAFAE------- 853

  Fly   659 AGGDGLDLLNVPSLSRRGSKNSKPSTRNN-SFTSLSSMAESMAQ----EASLQMQE--------- 709
                    |...|:|.|....:...||.: ||.|:...:..:.:    .||:|..|
Zfish   854 --------LKAFSVSERKESATLKGTRKSVSFLSIKDFSTDLIRGDLGSASIQTMEAISDPKLNQ 910

  Fly   710 --------TRVE----GKIGLGLYKEYL-TSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDK 761
                    |:.:    |::.|.:|.||. |.|.::  |..::||....|:...|.:|:||.|.|.
Zfish   911 DRDEVGRLTQADKAHTGRVKLEMYVEYFRTIGLAF--IIPIIFLYAFQQVASLAYNYWLSLWADD 973

  Fly   762 NVDGQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNT 826
            .|...|.:|||.: :..:.||..|..:.....|:......:.:|.|||..:...:..:.|.||.:
Zfish   974 PVINGTQVNTDLK-LGVYGALGFAQGIAIFGTTVAISLGGIIASRQLHLDLLNNVLHSPMSFFES 1037

  Fly   827 NPSGRILNRFSKDLGQLDEVLP---SVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYY 888
            .|||.:||||||::..:|.::|   .:||..|   ..||.:.:::.:..|:..::.|.|.:::.:
Zfish  1038 TPSGNLLNRFSKEIDAIDCMIPHGLKIMLGYV---FKLLEVCIIVLMATPFAGVIILPLTLLYAF 1099

  Fly   889 IREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFL 953
            |:.||:.||..::|||:|:|||||:|.:.|:.|...|||.|.|...|.:.:...||:.:.|:...
Zfish  1100 IQSFYVATSCQLRRLESVSRSPIYTHFNETVQGASVIRAFGEQPRFILQANCRVDLNQTSYFPRF 1164

  Fly   954 ATNRAFGYYLDCFCTLYIV-IIILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTM 1017
            ..:|.....|:....|.:: ..||:.......|||.||||::.::.:||::.|.:|...::||.:
Zfish  1165 VASRWLAVNLEFLGNLLVLAAAILSVMGRATLSPGTVGLAVSHSLQVTGILSWIVRSWTDVENNI 1229

  Fly  1018 TAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPC 1082
            .:||||.||.|...|..:...:...|| .||..|.|..:...|:|  .....:.||.::..:...
Zfish  1230 VSVERVKEYAETAKEAPWTFEDSPLPS-DWPRSGSIGFQAYGLQY--RKGLDWALKEISLSVNER 1291

  Fly  1083 EKVGIVGRTGAGKSSLINALFR-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMR 1146
            ||||||||||||||||...:|| |...:|.|.||..:.|::||.:|||:|:||||:|||||||:|
Zfish  1292 EKVGIVGRTGAGKSSLALGIFRILEAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLR 1356

  Fly  1147 YNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRV 1211
            .|||||:.|.|.::|.:||...||..:|:||:.|..:.||||.|.|:|||||:|||||:||:.::
Zfish  1357 INLDPFDRYTDEEVWRSLELAHLKTFVSDLPDKLNHECSEGGENLSLGQRQLICLARALLRKTKI 1421

  Fly  1212 LVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELL 1276
            ||:|||||.||.:||.|||:|||::|.||||||||||||||||..||:|||.|::.|..||..|:
Zfish  1422 LVLDEATAAVDLKTDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVMDRGNITEIDSPSNLI 1486

  Fly  1277 TSSESKIFHGMVMETG 1292
              |:...|:.|..|.|
Zfish  1487 --SQHGQFYRMCREAG 1500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	MRP_assoc_pro	13..1292	CDD:188098	497/1362 (36%)
abcc6b.2	XP_003198194.2	MRP_assoc_pro	5..1501	CDD:188098	501/1381 (36%)