DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mrp4 and abcc1

DIOPT Version :9

Sequence 1:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster
Sequence 2:	XP_001341895.3	Gene:	abcc1 / 100002010	ZFINID:	ZDB-GENE-050517-15	Length:	1518	Species:	Danio rerio

Alignment Length:	1360	Identity:	490/1360 - (36%)
Similarity:	746/1360 - (54%)	Gaps:	132/1360 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQ--------- 68
            |...:|.||.:.|.:...::.||.|:.||:|||:....|.||:.:..:|...||::
Zfish   209 PESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQECVKVKRPVD 273

  Fly    69 ------------------------------VAKNETPRLGRALTKVFGFHLFITGVFLLAQEFLT 103
                                          :.|...|.|..||.:.||.:..::.::.:..:.|.
Zfish   274 KTLYSPKRSTRGEKKDGQPVEESEILLAKALQKTGEPSLFFALCRTFGPYFLVSSLYKIIHDVLM 338

  Fly   104 KVTQPICLIGVMAYFAGNDPDRSKAQLWAAGLIAGSVF-SVCIGHPYMLGLLHL----GMKMRIA 163
            .|...|  :.::..|. ||   |.|..|........:| ..|:....:....|:    ||::|.|
Zfish   339 FVGPEI--LRLLILFV-ND---SSAPTWHGYFYTALLFVCTCLQTLILQKYFHVCFVTGMRLRTA 397

  Fly   164 LSSLIYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIG 228
            :...:|||||.::..|...:|||::|||:|.|..||..::..::.:|.|||::|...|.::..:|
Zfish   398 IVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLG 462

  Fly   229 ISSMFGVAIMLLFLPFQSYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVV 293
            .|.:.|||:|:|.:|..:.:..:|...::......|.|:::|||:::||:|:|:||||..|...|
Zfish   463 ASVLAGVAVMVLMVPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKGKV 527

  Fly   294 EMTRFNEMLCIKQVNYIRGILISF----AMFLSRIFTSSSLIAFVLL--GNILNAEKAFFVTAYY 352
            ...|.:|:..:|::.|: |.:.:|    |.||..:   |:...:||:  .|||:|:|||...|.:
Zfish   528 SAIRESELRVLKKMAYL-GAISTFTWVCAPFLVAL---STFAVYVLVDENNILDAQKAFVSLALF 588

  Fly   353 NILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGI 417
            ||||..:.| .|..||...:..||::||..|:               ::::.:..|.:.|..:|.
Zfish   589 NILRFPLNM-LPMVISSMVQASVSMQRLRVFL---------------SHEELDDDNVERPAISGT 637

  Fly   418 PENLIEFSQFQARWESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLR 482
            |:: |..:.....| |....|||:.||:.:....||||:|.||:|||||:.|:|||:..:.|::.
Zfish   638 PDS-IRIADGAFSW-SKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGSVS 700

  Fly   483 INGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASL 547
            |.||.:|..|:.|:...|::.|||||.:.....|:.||:.|||..|.|:||.||.|.:||:|.:|
Zfish   701 IKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTEIGEKGVNL 765

  Fly   548 SGGQKARISLARAVYRRADIYLLDDPLSAVDTHVGRHLFDQCM--RGYLRSELVILVTHQLQFLE 610
            |||||.|:|:|||||....:|||||||||||.|||:|:|::.:  :|.|:....:||||.|.||.
Zfish   766 SGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTRVLVTHGLSFLP 830

  Fly   611 QADLIVIMDKGRISAMGTYSS-MKRSGLDFAQLL-TAPNKDAEDLDEI--DGAGGDGLD------ 665
            |||||::|..|.|:.||:|:. :.|.|. ||:.| |..|.:.|:.:|.  |.....||:
Zfish   831 QADLILVMVDGEITEMGSYTELLGRQGA-FAEFLRTYTNTEQEEGEESLGDAVPRKGLENGGPAA 894

  Fly   666 LLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETRVEGKIGLGLYKEYLTSGSS 730
            ||....:|...:...|.:.:..:....::.....|:.:.|...:....|::.|.::.||:.:...
Zfish   895 LLRQSQISLNATGAGKTTQKTEANDDAAATKTKSAEASRLTEADKANTGRVKLSVFWEYMKAIGL 959

  Fly   731 WFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQ-----DMYYFAALNVAVVVFT 790
            ...| |.:||.....:....::|:||.|.|..|..    ||.|:     .:|....::..:.||.
Zfish   960 PLSI-FSIFLFFCHHLSSLGSNYWLSLWTDDPVVN----NTQPKREMRLGVYGALGISQGIAVFC 1019

  Fly   791 IVRTMLFYKMAMR-----SSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSV 850
                   |.:::.     :|..||..|...:.|:.|.||...|||.::|||:|:...:|.|:||:
Zfish  1020 -------YSVSVSVGGILASRYLHQTMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSI 1077

  Fly   851 MLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHL 915
            :...:.....:||...||.|..|...|:...|.:::::::.||:.:||.:||||:|:|||:|:|.
Zfish  1078 IKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQMKRLESVSRSPVYTHF 1142

  Fly   916 SATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLD----C---FCTLYIVI 973
            :.|:.|...|||.|.|:..|.|.|...|.:...|:..:..||.....|:    |   |..|:.|:
Zfish  1143 NETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVM 1207

  Fly   974 IILNYFINPPQSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSR 1038
            ...|.      |||.:||:|:.|:.:|..:.|.:|.|:|||..:.|||||.||.:.|.|.|:...
Zfish  1208 ARNNL------SPGIMGLSISYALQVTASLNWLVRMSSELETNIVAVERVKEYGDTEKEAEWKLE 1266

  Fly  1039 EGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLINALF 1103
            ....| |.||..|.|......|||..|  .:..:..::..|...||||||||||||||||...||
Zfish  1267 NSNLP-PGWPTAGHIEIHKFGLRYRED--LELAICDISVNIAGGEKVGIVGRTGAGKSSLTLGLF 1328

  Fly  1104 R-LSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALEEV 1167
            | :...||.|.||..:.||:||.:|||:|:||||:|||||||:|.|||||:.|.|.::|.:||..
Zfish  1329 RIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGSLRMNLDPFDGYTDEEVWRSLELA 1393

  Fly  1168 KLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQAT 1232
            .||..:|.||:.|..:.||||.|.|:|||||||||||:||:.::||:|||||.||.:||.|||:|
Zfish  1394 HLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQST 1458

  Fly  1233 IRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETG 1292
            ||::|.||||||||||||||||..||||:|.|.:.||.||..|:  ::..||:.|..::|
Zfish  1459 IRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLI--AKKGIFYKMAKDSG 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	486/1343 (36%)
		ABC_membrane	93..359	CDD:294371	86/276 (31%)
		ABCC_MRP_domain1	422..622	CDD:213217	97/201 (48%)
		ABC_membrane	735..978	CDD:294371	76/259 (29%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	128/221 (58%)
abcc1	XP_001341895.3	MRP_assoc_pro	7..1517	CDD:188098	490/1360 (36%)
		ABC_membrane	331..595	CDD:279056	86/273 (32%)
		ABCC_MRP_domain1	641..842	CDD:213217	97/201 (48%)
		ABC_membrane	966..1231	CDD:279056	84/281 (30%)
		ABCC_MRP_domain2	1278..1498	CDD:213211	128/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585973
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760