DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr5 and CADM3

DIOPT Version :9

Sequence 1:	NP_650080.3	Gene:	dpr5 / 41381	FlyBaseID:	FBgn0037908	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	XP_024304528.1	Gene:	CADM3 / 57863	HGNCID:	17601	Length:	481	Species:	Homo sapiens

Alignment Length:	285	Identity:	69/285 - (24%)
Similarity:	106/285 - (37%)	Gaps:	78/285 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 TTDREVIAALGTTARLHCRVRHLGDRAVSWIR--QRDLHILTIGIMTYTNDQRFLARHIDNSDEW 157
            |:|..|:|  |.|..|.|:|:...|.::.|..  |:.|         |..::|.|.   ||..:.
Human   118 TSDETVVA--GGTVVLKCQVKDHEDSSLQWSNPAQQTL---------YFGEKRALR---DNRIQL 168

  Fly   158 V--------LKIVSVQQRDAGVYECQVSTEPKISLAYKLVVVTSKAQ--ILANRELFIQSGSDIN 212
            |        :.|.:|...|.|.|.|.:.|.| :..|..||.|....|  |:...:..::......
Human   169 VTSTPHELSISISNVALADEGEYTCSIFTMP-VRTAKSLVTVLGIPQKPIITGYKSSLREKDTAT 232

  Fly   213 LTCIAPQAPG--PYTHMLWHK-DTELVSDSARGGIRVESEQQMKT---SNLVISRVQHTDSG-NY 270
            |.|   |:.|  |...:.|.| |.||..:..    |::.:...||   |:.|..:|...|.| :.
Human   233 LNC---QSSGSKPAARLTWRKGDQELHGEPT----RIQEDPNGKTFTVSSSVTFQVTREDDGASI 290

  Fly   271 TCS--------ADNSNSDSVFV-----HIIKSEQHAAMQHELGSRLLL----------------- 305
            .||        ||.|.|..:.|     .:|:.:.....:   |.:|||
Human   291 VCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPHPRE---GQKLLLHCEGRGNPVPQQYLWEK 352

  Fly   306 ----PPLPLLLLAVLLVVLLGPTSS 326
                |||.:...:.|:...|..:.|
Human   353 EGSVPPLKMTQESALIFPFLNKSDS 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr5	NP_650080.3	V-set	95..191	CDD:284989	30/105 (29%)
		IG_like	98..179	CDD:214653	23/90 (26%)
		IG_like	206..278	CDD:214653	22/86 (26%)
		Ig	211..278	CDD:143165	22/81 (27%)
CADM3	XP_024304528.1	Ig1_Necl-1	115..209	CDD:143290	30/105 (29%)
		Ig2_Necl-1	230..312	CDD:143329	24/88 (27%)
		IG_like	328..399	CDD:214653	10/53 (19%)
		4.1m	437..452	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5236
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960