DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr5 and Dscam2

DIOPT Version :9

Sequence 1:	NP_650080.3	Gene:	dpr5 / 41381	FlyBaseID:	FBgn0037908	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	335	Identity:	71/335 - (21%)
Similarity:	103/335 - (30%)	Gaps:	130/335 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 DREVI-AALGTTARLHC----RVRHLGDRAVSWIRQRDL------------HILTIGIMTYTN-- 142
            |.||: ||.|.||.|.|    .|:.| .|.|||:.:..:            |:|..|.:...|
  Fly   136 DVEVLSAARGCTAILRCVVPTFVKEL-VRVVSWVHEPAIYIYPSLQGDGKFHLLPTGELLIHNLQ 199

  Fly   143 ----DQRFLAR-----------------------------------HIDNSDE------------ 156
                .|.|..|                                   |:..|.:
  Fly   200 ESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQVSQDEGAVLLCVAQGC 264

  Fly   157 ------W----------------------VLKIVSVQQRDAGVYEC---QVSTEPKISLAYKLVV 190
                  |                      :|.|.:|...|:|||:|   .|..|....|  :|.|
  Fly   265 PSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEASAEL--RLTV 327

  Fly   191 VTSKAQILANRELFIQSGSDINLTCIAPQ--APGPYTHMLWHKDTELVSDSARGGIRVESEQQMK 253
            .|.....::...|.:..|......|:...  :|....::||:||...:..|.    |||
  Fly   328 ATPIQVEISPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKDGRQLPSSG----RVE------ 382

  Fly   254 TSNLVISRVQHTDSGNYTCSADNSNSDSVFVHIIKSEQHAAMQHELGSRLLLPPLPLLLLAVLLV 318
             ..||:.||...:.|.|.|.......|:.         .|..:.:||.   .||: ||...:...
  Fly   383 -DTLVVPRVSRENRGMYQCVVRRPEGDTF---------QATAELQLGD---APPV-LLYSFIEQT 433

  Fly   319 VLLGPTSSLQ 328
            :..||..||:
  Fly   434 LQPGPAVSLK 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr5	NP_650080.3	V-set	95..191	CDD:284989	38/194 (20%)
		IG_like	98..179	CDD:214653	34/181 (19%)
		IG_like	206..278	CDD:214653	18/73 (25%)
		Ig	211..278	CDD:143165	17/68 (25%)
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845	19/65 (29%)
		I-set	238..327	CDD:254352	15/90 (17%)
		Ig	247..327	CDD:299845	14/81 (17%)
		I-set	332..418	CDD:254352	21/105 (20%)
		IGc2	344..407	CDD:197706	18/73 (25%)
		IG_like	432..517	CDD:214653	4/12 (33%)
		IGc2	436..507	CDD:197706	4/8 (50%)
		I-set	521..610	CDD:254352
		IGc2	533..597	CDD:197706
		Ig	630..699	CDD:143165
		IG_like	714..802	CDD:214653
		Ig	725..802	CDD:299845
		Ig	823..894	CDD:143165
		FN3	906..1006	CDD:238020
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810