DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr5 and Sdk2

DIOPT Version :9

Sequence 1:	NP_650080.3	Gene:	dpr5 / 41381	FlyBaseID:	FBgn0037908	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	294	Identity:	65/294 - (22%)
Similarity:	111/294 - (37%)	Gaps:	75/294 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TSTTATESSPLI---------GKVISN-----SRAPQIAHEMLVE---YFMALLVIMGLTAPVDK 59
            |......:.|||         |.::||     :|...|.:.|:.:   |....::.....|||.:
  Rat   237 TMECVANARPLIKLHIVWKKDGALLSNGISDYNRRLTITNPMVSDAGYYECEAMLRSSSVAPVTR 301

  Fly    60 QSRRSSQYFGHLAAAEELSNLIPDNYDAIDPVFDNTTDREVIAALGTTARLHCRVRHLGDRAVSW 124
                          ...||.|.|       |.|....:|.:.|.:.....:.||.:.:...:::|
  Rat   302 --------------GAYLSVLEP-------PQFVREPERHITAEMEKVVDIPCRAKGVPPPSITW 345

  Fly   125 IRQRDLHILTIGIMTYTNDQRFLARHIDNSDEWVLKIVSVQQRDAGVYEC---------QVSTEP 180
              .:|..::.:|.:|     ||..|     .:..|:|..:...|.|:.:|         |.||
  Rat   346 --YKDAALVEVGKLT-----RFKQR-----SDGGLQISGLLPDDTGMVQCFAHNAAGEAQTST-- 396

  Fly   181 KISLAYKLVVVTSKAQILANREL--FIQSGSDINLTCIAPQAPGPYTHMLWHKDTELVSDSARGG 243
                   .:.|||.|..:....|  .:..|..:.|.|....||.|  .:.|.|...::   |.|.
  Rat   397 -------YLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRP--AITWQKGERIL---ASGS 449

  Fly   244 IRVESEQQMKTSNLVISRVQHTDSGNYTCSADNS 277
            :::.....:::.:|:||....:|:|.|||.|.||
  Rat   450 VQLPRFTLLESGSLLISPTHISDAGTYTCLATNS 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr5	NP_650080.3	V-set	95..191	CDD:284989	19/104 (18%)
		IG_like	98..179	CDD:214653	18/89 (20%)
		IG_like	206..278	CDD:214653	21/72 (29%)
		Ig	211..278	CDD:143165	20/67 (30%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653
		IGc2	43..101	CDD:197706
		IG_like	123..206	CDD:214653
		Ig	135..191	CDD:299845
		IG_like	225..307	CDD:214653	15/83 (18%)
		IGc2	236..289	CDD:197706	11/51 (22%)
		I-set	311..400	CDD:254352	21/109 (19%)
		Ig	329..397	CDD:143165	17/88 (19%)
		I-set	405..495	CDD:254352	22/84 (26%)
		Ig	419..495	CDD:299845	21/70 (30%)
		Ig	505..589	CDD:299845
		IG_like	505..589	CDD:214653
		FN3	593..684	CDD:238020
		FN3	696..789	CDD:238020
		FN3	797..893	CDD:238020
		FN3	898..986	CDD:238020
		FN3	996..1090	CDD:238020
		FN3	1102..1197	CDD:238020
		FN3	1204..1293	CDD:238020
		FN3	1304..1397	CDD:238020
		FN3	1403..1487	CDD:238020
		FN3	1506..1619	CDD:238020
		FN3	1629..1722	CDD:238020
		FN3	1727..1808	CDD:238020
		FN3	1840..1919	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810