DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr5 and Negr1

DIOPT Version :9

Sequence 1:	NP_650080.3	Gene:	dpr5 / 41381	FlyBaseID:	FBgn0037908	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	XP_036019026.1	Gene:	Negr1 / 320840	MGIID:	2444846	Length:	362	Species:	Mus musculus

Alignment Length:	191	Identity:	54/191 - (28%)
Similarity:	85/191 - (44%)	Gaps:	30/191 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 DNTTDREVIAALGTTARLHCRVRHLGDRAV--SWIRQRDLHILTIGIMTYTNDQRFLARHIDNSD 155
            ||...|:     |.||.|.|   :|.|.|.  :|:.:..  |:..|...::.|.|.....: |..
Mouse    40 DNMLVRK-----GDTAVLRC---YLEDGASKGAWLNRSS--IIFAGGDKWSVDPRVSISTL-NKR 93

  Fly   156 EWVLKIVSVQQRDAGVYECQVSTE--PKISLAYKLVVVTSKAQILANRELFIQSGSDINLTCIAP 218
            ::.|:|.:|...|.|.|.|.|.|:  |:....:..|.|..|...::| ::.|..|:::.|||:|.
Mouse    94 DYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISN-DMTINEGTNVTLTCLAT 157

  Fly   219 QAPGPYTHMLWHKDTELVSDSARGGIRVESEQQMKTSNLVISRVQHTDSGNYTCSADNSNS 279
            ..|.|.  :.|..    :|.||:   ..|:.|.     |.|..:....:|.|.|||:|..|
Mouse   158 GKPEPV--ISWRH----ISPSAK---PFENGQY-----LDIYGITRDQAGEYECSAENDVS 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr5	NP_650080.3	V-set	95..191	CDD:284989	26/99 (26%)
		IG_like	98..179	CDD:214653	23/82 (28%)
		IG_like	206..278	CDD:214653	21/71 (30%)
		Ig	211..278	CDD:143165	20/66 (30%)
Negr1	XP_036019026.1	FR1	38..55	CDD:409353	8/22 (36%)
		Ig strand A'	40..46	CDD:409353	2/5 (40%)
		IG_like	41..129	CDD:214653	26/98 (27%)
		Ig strand B	48..56	CDD:409353	4/10 (40%)
		CDR1	56..60	CDD:409353	2/3 (67%)
		FR2	61..68	CDD:409353	1/6 (17%)
		Ig strand C	61..67	CDD:409353	1/5 (20%)
		CDR2	69..79	CDD:409353	2/11 (18%)
		Ig strand C'	71..74	CDD:409353	1/2 (50%)
		Ig strand C'	76..79	CDD:409353	0/2 (0%)
		FR3	80..115	CDD:409353	10/35 (29%)
		Ig strand D	84..91	CDD:409353	1/7 (14%)
		Ig strand E	94..100	CDD:409353	1/5 (20%)
		Ig strand F	107..115	CDD:409353	3/7 (43%)
		CDR3	116..120	CDD:409353	1/3 (33%)
		Ig strand G	120..129	CDD:409353	1/8 (13%)
		FR4	122..129	CDD:409353	0/6 (0%)
		Ig strand A'	139..144	CDD:409353	1/5 (20%)
		IGc2	146..204	CDD:197706	21/71 (30%)
		Ig strand B	150..157	CDD:409353	3/6 (50%)
		Ig strand C	163..168	CDD:409353	1/6 (17%)
		Ig strand C'	170..172	CDD:409353	1/1 (100%)
		Ig strand E	180..186	CDD:409353	3/10 (30%)
		Ig strand F	193..200	CDD:409353	4/6 (67%)
		Ig_3	219..295	CDD:404760
		putative Ig strand A	219..225	CDD:409353
		Ig strand B	235..239	CDD:409353
		Ig strand C	248..252	CDD:409353
		Ig strand E	274..278	CDD:409353
		Ig strand F	288..293	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810