DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr5 and NEGR1

DIOPT Version :9

Sequence 1:	NP_650080.3	Gene:	dpr5 / 41381	FlyBaseID:	FBgn0037908	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens

Alignment Length:	191	Identity:	53/191 - (27%)
Similarity:	85/191 - (44%)	Gaps:	30/191 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 DNTTDREVIAALGTTARLHCRVRHLGDRAV--SWIRQRDLHILTIGIMTYTNDQRFLARHIDNSD 155
            ||...|:     |.||.|.|   :|.|.|.  :|:.:..  |:..|...::.|.|.....: |..
Human    46 DNMMVRK-----GDTAVLRC---YLEDGASKGAWLNRSS--IIFAGGDKWSVDPRVSISTL-NKR 99

  Fly   156 EWVLKIVSVQQRDAGVYECQVSTE--PKISLAYKLVVVTSKAQILANRELFIQSGSDINLTCIAP 218
            ::.|:|.:|...|.|.|.|.|.|:  |:....:..|.|..|...::| ::.:..|:::.|||:|.
Human   100 DYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISN-DMTVNEGTNVTLTCLAT 163

  Fly   219 QAPGPYTHMLWHKDTELVSDSARGGIRVESEQQMKTSNLVISRVQHTDSGNYTCSADNSNS 279
            ..|.|  .:.|..    :|.||:   ..|:.|.     |.|..:....:|.|.|||:|..|
Human   164 GKPEP--SISWRH----ISPSAK---PFENGQY-----LDIYGITRDQAGEYECSAENDVS 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr5	NP_650080.3	V-set	95..191	CDD:284989	26/99 (26%)
		IG_like	98..179	CDD:214653	23/82 (28%)
		IG_like	206..278	CDD:214653	21/71 (30%)
		Ig	211..278	CDD:143165	20/66 (30%)
NEGR1	NP_776169.2	IG	47..135	CDD:214652	26/98 (27%)
		IGc2	152..210	CDD:197706	21/71 (30%)
		Ig_3	225..301	CDD:372822
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810