DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr5 and Lrit1

DIOPT Version :9

Sequence 1:	NP_650080.3	Gene:	dpr5 / 41381	FlyBaseID:	FBgn0037908	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_647547.2	Gene:	Lrit1 / 246214	RGDID:	628607	Length:	623	Species:	Rattus norvegicus

Alignment Length:	259	Identity:	59/259 - (22%)
Similarity:	87/259 - (33%)	Gaps:	79/259 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 AEELSNLIP------DNYDAIDPVFDNTTDREVIAALGTTARLHC-------RVR-HLGDRAVSW 124
            |..||.|.|      :|...:| :.:|...|.....|.|.|.|..       |.| .||.:...|
  Rat   140 ANRLSTLPPEAVHFLENLTFLD-LSNNQLMRLPEELLDTWAHLKTGPYLSSRRTRLVLGLQDNPW 203

  Fly   125 I---RQRDL-HILTIGIMTYTNDQRFLARHIDNSDEWVLKIVSVQQR--------DAGV------ 171
            :   |..|| |:|                     |.|...::.::.|        .|||
  Rat   204 VCDCRLYDLVHLL---------------------DGWASNLIFIEARLRCGSPRSLAGVAFSQLE 247

  Fly   172 -YECQVSTEPKISLAYKLVVVTSKAQILANRELFIQSGSDINLTCIAPQAPGPYTHMLWHKDTEL 235
             .:||   .|::...     |||         :....||.:.|.|.|...|||  .|.|.:..
  Rat   248 LRKCQ---SPELRPG-----VTS---------IISPLGSTVLLRCGATGIPGP--EMSWRRAN-- 291

  Fly   236 VSDSARGGIRVE-SEQQMKTSNLVISRVQHTDSGNYTCSADN-SNSDSVFVHIIKSEQHAAMQH 297
             .....|.:..| |......:.|.:..|...|||:|.|.|.| ..:....:.:|.:|...:.::
  Rat   292 -GRPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGASETLISLIVTEPQTSTEY 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr5	NP_650080.3	V-set	95..191	CDD:284989	24/122 (20%)
		IG_like	98..179	CDD:214653	23/107 (21%)
		IG_like	206..278	CDD:214653	22/73 (30%)
		Ig	211..278	CDD:143165	20/68 (29%)
Lrit1	NP_647547.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566	1/2 (50%)
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..128
		LRR_8	131..>176	CDD:290566	9/36 (25%)
		LRR_4	131..172	CDD:289563	9/32 (28%)
		LRR 4	132..153		5/12 (42%)
		leucine-rich repeat	133..156	CDD:275378	5/15 (33%)
		LRR 5	156..177		5/21 (24%)
		leucine-rich repeat	157..180	CDD:275378	5/23 (22%)
		leucine-rich repeat	181..205	CDD:275378	6/23 (26%)
		TPKR_C2	201..>240	CDD:301599	9/59 (15%)
		Ig	257..345	CDD:299845	25/106 (24%)
		IG_like	267..345	CDD:214653	22/82 (27%)
		FN3	431..501	CDD:214495
		LRR 6	525..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900