DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr5 and Lrit1

DIOPT Version :9

Sequence 1:	NP_650080.3	Gene:	dpr5 / 41381	FlyBaseID:	FBgn0037908	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_666357.2	Gene:	Lrit1 / 239037	MGIID:	2385320	Length:	624	Species:	Mus musculus

Alignment Length:	246	Identity:	53/246 - (21%)
Similarity:	80/246 - (32%)	Gaps:	68/246 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 VIAALGTTARLHCRVRHLGDRAVSWIRQ--RDLHILTIGIMTYTNDQRFLARHIDNSDEWVLKIV 162
            :|:.||:|..|.|....:....:||.|.  |.|:        .|..|...:   |.|...:|.:.
Mouse   264 IISPLGSTVLLRCGATGIPGPEMSWRRANGRPLN--------GTVHQEVSS---DGSSWTLLDLP 317

  Fly   163 SVQQRDAGVYECQ--------------VSTEPKISLAYKLVVVTSKAQILANRELFIQSGSDINL 213
            .|...|:|.|.||              :.|||:.|..|..:.....|:.....|     .:..|.
Mouse   318 VVSLFDSGDYICQAKNFLGASETLISLIVTEPQTSTGYSGIPGVLWARTGEGAE-----AAAYNN 377

  Fly   214 TCIAPQAPGPYTHMLWHKDTELVSDSARGGIRVE---------------------SEQQMKTSNL 257
            ..:|...|    ||..|  ..|.:..:...|:.|                     .|.||..|..
Mouse   378 KLVARHVP----HMPEH--VALATKPSMPSIKEELALQNFQMDVPGEFSREPSEHQEAQMVRSLK 436

  Fly   258 VISRVQHTDSGNYTC-SADNSNSDSVFVHIIKSEQHAAMQHELGSRLLLPP 307
            |:....|:.|..:.. .|.|:.:.||.        :|...|....|:.:.|
Mouse   437 VVGDTYHSVSLVWKAPQAGNTTAFSVL--------YAVFGHRDMRRMTVEP 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr5	NP_650080.3	V-set	95..191	CDD:284989	27/106 (25%)
		IG_like	98..179	CDD:214653	22/94 (23%)
		IG_like	206..278	CDD:214653	18/93 (19%)
		Ig	211..278	CDD:143165	18/88 (20%)
Lrit1	NP_666357.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..129
		LRR_8	131..>176	CDD:290566
		LRR_4	131..172	CDD:289563
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378
		LRR 5	156..177
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..205	CDD:275378
		TPKR_C2	201..>241	CDD:301599
		Ig	258..346	CDD:299845	22/92 (24%)
		IG_like	268..346	CDD:214653	21/88 (24%)
		FN3	432..502	CDD:214495	12/56 (21%)
		LRR 6	526..549
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900