DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr5 and CADM4

DIOPT Version :9

Sequence 1:	NP_650080.3	Gene:	dpr5 / 41381	FlyBaseID:	FBgn0037908	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_660339.1	Gene:	CADM4 / 199731	HGNCID:	30825	Length:	388	Species:	Homo sapiens

Alignment Length:	187	Identity:	49/187 - (26%)
Similarity:	80/187 - (42%)	Gaps:	25/187 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 VIAALGTTARLHCRVRHLGDRAVSWIRQRDLHILTIGIMTYTNDQRFLARHIDNSDEWVLKIVSV 164
            |..|.|..|.:.||: |..|.::..|:......|.........|:||      ..:|:..:.|.:
Human    32 VTVAEGGVAEITCRL-HQYDGSIVVIQNPARQTLFFNGTRALKDERF------QLEEFSPRRVRI 89

  Fly   165 QQRDA-----GVYECQVSTE-PKISLAYKLVVVTSKAQILANRELFIQSGSDINLTCIAPQAPGP 223
            :..||     |.|.||:.|| ....:|...|:|..:..::..||..:: |.::.|:|:.|:: .|
Human    90 RLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVE-GGEVELSCLVPRS-RP 152

  Fly   224 YTHMLWHKD-TEL--VSDSARGGIRVESEQQMKTSNLVISRVQHTDSGN-YTCSADN 276
            ...:.|::| .||  ||.|...|      :....::.|..||...|.|. ..|.|.|
Human   153 AATLRWYRDRKELKGVSSSQENG------KVWSVASTVRFRVDRKDDGGIIICEAQN 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr5	NP_650080.3	V-set	95..191	CDD:284989	25/96 (26%)
		IG_like	98..179	CDD:214653	21/83 (25%)
		IG_like	206..278	CDD:214653	21/75 (28%)
		Ig	211..278	CDD:143165	20/70 (29%)
CADM4	NP_660339.1	Ig	29..120	CDD:416386	24/94 (26%)
		FR1	29..45	CDD:409353	4/12 (33%)
		Ig strand A'	30..36	CDD:409353	1/3 (33%)
		Ig strand B	38..46	CDD:409353	2/7 (29%)
		CDR1	46..51	CDD:409353	1/5 (20%)
		FR2	52..59	CDD:409353	1/6 (17%)
		Ig strand C	52..58	CDD:409353	1/5 (20%)
		CDR2	60..71	CDD:409353	1/10 (10%)
		Ig strand C'	62..66	CDD:409353	1/3 (33%)
		Ig strand C'	68..71	CDD:409353	0/2 (0%)
		FR3	72..107	CDD:409353	11/40 (28%)
		Ig strand D	76..83	CDD:409353	3/12 (25%)
		Ig strand E	86..92	CDD:409353	1/5 (20%)
		Ig strand F	99..107	CDD:409353	4/7 (57%)
		CDR3	108..111	CDD:409353	2/2 (100%)
		Ig strand G	111..120	CDD:409353	1/8 (13%)
		FR4	113..120	CDD:409353	1/6 (17%)
		IgI_2_Necl-4	121..220	CDD:409468	24/91 (26%)
		Ig strand B	141..145	CDD:409468	1/3 (33%)
		Ig strand C	155..159	CDD:409468	0/3 (0%)
		Ig strand E	182..186	CDD:409468	1/3 (33%)
		Ig strand F	196..201	CDD:409468	1/4 (25%)
		Ig strand G	213..216	CDD:409468
		Ig_3	224..295	CDD:404760
		Ig strand A'	231..235	CDD:409353
		Ig strand B	241..248	CDD:409353
		Ig strand C	255..260	CDD:409353
		Ig strand C'	262..264	CDD:409353
		Ig strand E	274..280	CDD:409353
		Ig strand F	287..294	CDD:409353
		Ig strand G	300..308	CDD:409353
		4.1m	344..362	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5236
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960