Protein Alignment CG17230 and TCHP

DIOPT Version :10

• Sequence 1: NP_650077.1
• Gene: CG17230 / 41376
• FlyBaseID: FBgn0046225
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_115676.1
• Gene: TCHP / 84260
• HGNCID: 28135
• Length: 498
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 123/546 - (22%)
• Similarity: 240/546 - (43%)
• Gaps: 112/546 - (20%)

  Fly     4 RLNHQHAAYAHRMEQEHNRVQATQAVNSYYSHWGKV-TSRFENWTNKEYYEKADQQLQSRRDQQE 67
            |||.|.|    |..::..|::.....||.|.....: :|:...|::|..|:::....|..:.::|
Human    15 RLNQQLA----RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75

  Fly    68 KEAALNERRSRLRQLLASESEEYNNEME--------RRRRPREPGGGDLQMLDRVNQSLKEQEQL 124
            |..:|..||.:||||:..|.:....|:|        :.||.||..|           .||..::.
Human    76 KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHG-----------KLKSAKEE 129

  Fly   125 RRKLEMEAKLYGRW----------------RHGVDDEKLLYQSKSDNEVLAKLNWLDRQIESQQQ 173
            :|||..|..||..|                :|.|:..::..:.|...|..|:..  :::.|::.:
Human   130 QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQE--NKRYENEYE 192

  Fly   174 REEQQALAAERQLLLQQEISRTEQAQKERQQIREQQLRELRALQESHMSELRLRQQEADKLKEEE 238
            |..::||  ||.           :|::||:|: |.:|:....||:  |.||:|::.||.|||:|:
Human   193 RARREAL--ERM-----------KAEEERRQL-EDKLQAEALLQQ--MEELKLKEVEATKLKKEQ 241

  Fly   239 QHF---QLFLGELDKERELLEESSALVLKQVDSG----HAFN--LKKIKVFIRQRSEASRKQISL 294
            ::.   :..|..|::||:.:|    ...::.:.|    |.:|  |.:....|::..||.|:.:..
Human   242 ENLLKQRWELERLEEERKQME----AFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQA 302

  Fly   295 CI------NMLH--RMAKYVVKTEELKTLLDKYRSQLENEELACAQIESMYESEAKYNLQRSEEN 351
            .:      ..||  |..:.:.....:|..:::   ||:.|....|:::.:...|||...::.|..
Human   303 LLEKEDESQRLHLARREQVMADVAWMKQAIEE---QLQLERAREAELQMLLREEAKEMWEKREAE 364

  Fly   352 WREQHLQRYGELSKFIDQEKDCLGAMLQENVSQQQTLVELRSQHLTGIEQANKQLEQLSQVQADE 416
            |..:...|...:|:.:...:..:...:::|...|:..::.|.|.:..:|    ::.:|::.:.:|
Human   365 WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLE----EVRELARREKEE 425

  Fly   417 VPAPSQSNLKEVESQSSVSETSVEENLLPKVSDSFSNLNLDVWK-DLPPARSEVDMQRLNQ-SRS 479
            ......:..:|:|:|  |:|.                 .|..|: |......|.:.:|:.| |.:
Human   426 SEKLKSARKQELEAQ--VAER-----------------RLQAWEADQQEEEEEEEARRVEQLSDA 471

  Fly   480 LSVVTSQTAA-----PPKFARKRVAW 500
            |....::|.|     |..:...::||
Human   472 LLQQEAETMAEQGYRPKPYGHPKIAW 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17230	NP_650077.1	EnvC	53..>260	CDD:443969	61/233 (26%)
		Smc	<158..>427	CDD:440809	60/285 (21%)
TCHP	NP_115676.1	Interaction with keratin proteins. /evidence=ECO:0000269|PubMed:15731013	73..498		108/484 (22%)
		TPH	146..483	CDD:464007	79/384 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..189		3/23 (13%)
		Trichohyalin/plectin homology domain. /evidence=ECO:0000269|PubMed:15731013	259..425		30/176 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..498		12/51 (24%)