Protein Alignment CG17230 and tchp

DIOPT Version :10

• Sequence 1: NP_650077.1
• Gene: CG17230 / 41376
• FlyBaseID: FBgn0046225
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001035433.1
• Gene: tchp / 678595
• ZFINID: ZDB-GENE-060421-3368
• Length: 499
• Species: Danio rerio
• Alignment Length: 544
• Identity: 123/544 - (22%)
• Similarity: 226/544 - (41%)
• Gaps: 113/544 - (20%)

  Fly     4 RLNHQHAAYAHRMEQEHNRVQATQAVNSYYSHWGKVTSRFENWTNKEYYEKADQQLQSRRDQQEK 68
            |...|.|....:.|| |::....|.|.|         |:...|::::.:.::....|..|.::||
Zfish    23 RQREQEARLRRQWEQ-HSQYFREQDVRS---------SKQAQWSSRQSFHRSMSAFQRDRMREEK 77

  Fly    69 EAALNERRSRLRQLLASESEEYNNEMERRRRPREPGGGDL--QMLDRVNQSLKEQEQLRRKLEME 131
            :..|.|||.|||.:|    :|..:::|...|...|....|  |::::.:.....:|:.|:.|..|
Zfish    78 QRKLEERRERLRTML----QEERDQLEAELRNIHPDRDTLARQLVEKTDALRSAREERRKNLAQE 138

  Fly   132 AKLYGRWRHGVDDEKLLYQSKSDNEVLAKL-----------NWLDRQIESQQQREEQQALAAERQ 185
            . |...|             |.:|..|.|:           .|   |::.|::::..:....|:|
Zfish   139 L-LREHW-------------KQNNSQLRKVESELHKDHIVSQW---QVQQQEKKQADERTQEEKQ 186

  Fly   186 LLLQQEISRTEQAQKERQQIREQQLR--ELRALQE--SHMSELRLRQQEADKLKEEEQHFQLFLG 246
             ..:.|..||.|...||.:..|:..:  |.:..:|  ..|.||:||:|||::||:|::.......
Zfish   187 -RFENEYERTRQEALERMRKEEENRKWEEKKRAEELLKQMEELKLREQEAERLKQEQETLMSKRW 250

  Fly   247 ELDK---ERELLEESSALVLKQVDSG------HAFNLKKIKVFIRQRSEASRKQISLCI------ 296
            ||:|   ||:::|||.    ::.:.|      :...||:....:::..||.||.::..:
Zfish   251 ELEKLEDERKMMEESR----RKTEFGRFLTRQYRAQLKRRAQQVQEELEADRKILAALLEGELDE 311

  Fly   297 NMLH--RMAKYVVKTEELKTLLDKYRSQLENEELACAQIESMYESEAKYNLQRSEENWREQHLQR 359
            ...|  |..:.|.....:|.:::: :.|||.|..  |:.:.:|..||:...::.|..|.::...|
Zfish   312 QRFHKARRERAVADAAWMKRVIEE-QLQLERERE--AEFDILYREEAQRVWEKREAEWEKERRAR 373

  Fly   360 YGELSKFIDQEKDCLGAMLQENVSQQQTLVELRSQHLTGIEQ-------ANKQLEQLSQVQADEV 417
            ...:.:.:...:..|...:|||...::..::.|.:.|..:||       ..:|.|.|...:..|:
Zfish   374 ERLMREVLAGRQQQLQERMQENRLAREESLQRREELLQQLEQDRLTLRLEKEQQEGLRTARIQEI 438

  Fly   418 PAPSQSNLKEV-ESQSSVSETSVEENLLPKVSDSFSNLNLDVWKDLPPARSEVDMQ----RLNQS 477
            ....:...||. |.|.::.:...:|                        |.|:.:|    ||...
Zfish   439 DNQVEQRRKEQWEQQQTLEQEEAQE------------------------REELRLQEEELRLETD 479

  Fly   478 RSLSVVTSQTAAPPKFARKRVAWT 501
            |.:    .|.......:|.|.|||
Zfish   480 RMI----RQGFQERIHSRPRSAWT 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17230	NP_650077.1	EnvC	53..>260	CDD:443969	61/226 (27%)
		Smc	<158..>427	CDD:440809	69/307 (22%)
tchp	NP_001035433.1	DUF5401	<12..236	CDD:375164	60/244 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..78		7/40 (18%)
		Interaction with keratin proteins. /evidence=ECO:0000250|UniProtKB:Q9BT92	74..499		108/481 (22%)
		TPH	144..484	CDD:464007	83/391 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..209		10/40 (25%)
		Trichohyalin/plectin homology domain. /evidence=ECO:0000250|UniProtKB:Q9BT92	260..426		33/172 (19%)