DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17230 and IVL

DIOPT Version :9

Sequence 1:	NP_001287289.1	Gene:	CG17230 / 41376	FlyBaseID:	FBgn0046225	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_005538.2	Gene:	IVL / 3713	HGNCID:	6187	Length:	585	Species:	Homo sapiens

Alignment Length:	450	Identity:	112/450 - (24%)
Similarity:	198/450 - (44%)	Gaps:	85/450 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ENWTNKEYYEKA---DQQL---QSRRDQQEKEAALNERR---SRLRQLLASESEEYNNEMERRRR 99
            ::|...|.|:||   :|||   :::||||..:....|::   .:|.|.|....|:...:.|:...
Human    90 QHWEQHEEYQKAENPEQQLKQEKTQRDQQLNKQLEEEKKLLDQQLDQELVKRDEQLGMKKEQLLE 154

  Fly   100 PREPGGGDLQMLDRVNQSLKEQEQLRRKLEMEAKLYGRWRHGVDDE---KLLYQSKSDNEVLAKL 161
            ..|...|.|:.|::....||..||...:||:..:..|:.......|   :|..|.:...|
Human   155 LPEQQEGHLKHLEQQEGQLKHPEQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLE----- 214

  Fly   162 NWLDRQIESQQQREEQQALAAERQLLLQQ------EISRTEQAQKERQQIREQQLRELR------ 214
              |..|.|.|.:..|||    |.||.|.|      |:|..::.|.|..:.:|.||:.|.
Human   215 --LPEQQEGQLELPEQQ----EGQLELPQQQEGQLELSEQQEGQLELSEQQEGQLKHLEHQEGQL 273

  Fly   215 ALQESHMSELRLRQQEADKLKEEEQHFQLFLGELDKERELLEESSALVLKQVD--SGHAFNLKKI 277
            .:.|..|.:|:..:|:..:||..:|.        :|:.||.|:... .||.::  .|...:|::.
Human   274 EVPEEQMGQLKYLEQQEGQLKHLDQQ--------EKQPELPEQQMG-QLKHLEQQEGQPKHLEQQ 329

  Fly   278 KVFIRQRSEAS------RKQISLCINMLHRMAKYVVKTEELKTL--LDKYRSQ---LENEELACA 331
            :..:.|..|..      .:|.....::.|:..:..:..:::..|  |:|.:.|   ||.||   .
Human   330 EGQLEQLEEQEGQLKHLEQQEGQLEHLEHQEGQLGLPEQQVLQLKQLEKQQGQPKHLEEEE---G 391

  Fly   332 QIESMYESEA--KYNLQRS---EENWRE-QHL-QRYGELSKFIDQEKDCLGAMLQENVSQQQTLV 389
            |::.:.:.|.  |:.:|:.   |:..|: :|| |:.|:|....:||    |.:  :::.|||..:
Human   392 QLKHLVQQEGQLKHLVQQEGQLEQQERQVEHLEQQVGQLKHLEEQE----GQL--KHLEQQQGQL 450

  Fly   390 ELRSQHL---TGIEQANKQLEQLSQVQADEVPAPSQSNLKEVESQSSVSETSVEENLLPK 446
            |:..|.:   ..:||..|||         |:|...:..:|.:|.|.:..|...::...||
Human   451 EVPEQQVGQPKNLEQEEKQL---------ELPEQQEGQVKHLEKQEAQLELPEQQVGQPK 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17230	NP_001287289.1	Smc	<49..350	CDD:224117	83/342 (24%)
IVL	NP_005538.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..132		13/41 (32%)
		Involucrin_N	1..69	CDD:287543
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..540		94/390 (24%)
		39 X 10 AA approximate tandem repeats of [LP]-[EKG]-[LHVYQEK]-[PLSQE]-[EQDV]-[QHEKRGA]-Q-[EMVQLP]- [GKLE]-[QHVNLD]	153..542		93/386 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000