DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17230 and Tchp

DIOPT Version :9

Sequence 1:	NP_001287289.1	Gene:	CG17230 / 41376	FlyBaseID:	FBgn0046225	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001178595.1	Gene:	Tchp / 304547	RGDID:	1310813	Length:	497	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	126/542 - (23%)
Similarity:	240/542 - (44%)	Gaps:	104/542 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NHQHAAYAHRMEQEHNRVQATQAVNS-YYSHWGKVTSRFENWTNKEYYEKADQQLQSRRDQQEKE 69
            |.:.|...:|.:|:.:..:.....|| |:..|....|:...||:|..|:::...|...:.::|:.
  Rat    12 NRRPANIRYRQQQQEDEFRQQWEQNSRYFKTWDLHNSKQTEWTSKTSYQRSMHALYCGKMEEERR 76

  Fly    70 AALNERRSRLRQLLASESEEYNNEME--------RRRRPREPGGGDLQMLDRVNQSLKEQEQLRR 126
            ..|..||.|||:|:..|.:....|:|        |.||.||.           ::.||...:.:|
  Rat    77 KNLEVRRERLRKLMLEEQDLLAEELEELRLSMSLRERRLREQ-----------HRDLKSAREEQR 130

  Fly   127 KLEMEAKLYGRWRHGVDDEKL------LYQSKSDNEVLAKLNWLDRQIESQQQR--EEQQALAAE 183
            ||..|..||..||.  ::.||      |::....|      :|..::.|.:||.  |:|:....|
  Rat   131 KLMAEQLLYEHWRK--NNPKLREIELDLHKKHVIN------SWATQKEEKKQQEATEKQENKQFE 187

  Fly   184 RQ-LLLQQEISRTEQAQKERQQIREQQLRELRALQESHMSELRLRQQEADKLKEEE-----QHFQ 242
            .: ...:||.....:|::||:|:..|...|  ||:: .|.||:.::.||.|||:|:     ||::
  Rat   188 NEYAAARQEAEARLKAEEERKQLEGQLQGE--ALRQ-QMEELKQKEMEATKLKKEQENLLKQHWE 249

  Fly   243 LFLGELDKERELLEESSALVLKQVDSG----HAFN--LKKIKVFIRQRSEASRKQISLCINM--- 298
              |..||.||:.:    |:|.::.:.|    |.:|  |.:....|::..||..:.:...:..
  Rat   250 --LERLDDERKQM----AIVRRKTELGRILRHQYNAQLNRRTQQIQEELEADGRILQALLEKDNE 308

  Fly   299 -----LHRMAKYVVKTEELKTLLDKYRSQLENEELACAQIESMYESEAKYNLQRSEENWREQHLQ 358
                 |.|..:.:....::|.::::   ||:.|:...|:::.:...|||...::.|..|..:...
  Rat   309 LQQVELARREQAMADAAQMKQVIEE---QLQLEKAREAELQQLLREEAKEMWEKREAEWAREQSA 370

  Fly   359 RYGELSKFIDQEKDCLGAMLQENVSQQQTLVELRSQHLTGIEQANKQLEQLSQVQADEVPAPSQS 423
            |...:|:.:...:..:...:::|...|:..::.|.:.:..:|: .|||...::.:::|:   ..:
  Rat   371 RDKLMSEVLTGRQQQIQEKIEQNRRAQEETLKYREELIKSLEE-GKQLALRAKEESEEL---KSA 431

  Fly   424 NLKEVESQSSVSETSVEENLLPKVSDSFSNLNLDVWKDLPPARSEVDMQR-LNQSRSLSVVTSQT 487
            ..:|:|:|  |:|...:|                 |:   .||.|.:.:: ..::..||....|.
  Rat   432 RKQELEAQ--VAERQFQE-----------------WE---AARQEEEEEKEAKKAEQLSNARLQQ 474

  Fly   488 AA---------PPKFARKRVAW 500
            .|         |......|:||
  Rat   475 EARTMVKRGYRPKIHGHLRIAW 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17230	NP_001287289.1	Smc	<49..350	CDD:224117	85/336 (25%)
Tchp	NP_001178595.1	TPH	142..481	CDD:404709	84/384 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28P5M
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52265
OrthoDB	1	1.010	-	-		D299663at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR31183
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020