DRSC/TRiP Functional Genomics Resources

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Protein Alignment Exd2 and WRN

DIOPT Version :10

Sequence 1:NP_650075.1 Gene:Exd2 / 41374 FlyBaseID:FBgn0037901 Length:583 Species:Drosophila melanogaster
Sequence 2:NP_000544.2 Gene:WRN / 7486 HGNCID:12791 Length:1432 Species:Homo sapiens


Alignment Length:439 Identity:107/439 - (24%)
Similarity:153/439 - (34%) Gaps:121/439 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 VLGFDCEW--ITVGGSRRPVALLQLSSHRGLCALFRLCHMKQIPQDLRELLEDDSVIKVGVAPQE 141
            |:|||.||  :...|....|||:||......|.||.:..|...||.|:.|||:.:|.|.||..:.
Human    78 VVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEG 142

  Fly   142 DAMKLSHDYGVGVASTLDL------RFLCVMAGHKPEGLGKLSKTHLNYTLDKHWRLACSNWEAK 200
            |..||..|:.:.:.:.::|      :..|.    :...|..|.|..|...|.|...:.||||...
Human   143 DQWKLLRDFDIKLKNFVELTDVANKKLKCT----ETWSLNSLVKHLLGKQLLKDKSIRCSNWSKF 203

  Fly   201 TLEPKQLDYAANDALMAVAIYQKLCRDLQPKHFWQRRQLDDNSMH---NKFEPFLDVDFTKGFTL 262
            .|...|..|||.||.....||:.|            ..|||....   ||.|..|..|..|..| 
Human   204 PLTEDQKLYAATDAYAGFIIYRNL------------EILDDTVQRFAINKEEEILLSDMNKQLT- 255

  Fly   263 NPSGSGVTRSKGSTQSKSNKWVP----KKQPYRQIATRTKDFYDNCLLQAPDGELLCTIDRRKAS 323
                     |.........|.:|    |.:..|:::...||..:|          |.::.|....
Human   256 ---------SISEEVMDLAKHLPHAFSKLENPRRVSILLKDISEN----------LYSLRRMIIG 301

  Fly   324 WYLNQNLGTHISEEPFTVRLNFEPAGRAVGDVGRFYQTIKKNQCVVCGDRDAYIRKNVVPREYRK 388
               :.|:.|.:........|:||.:  ..|.|.:                          ::.|:
Human   302 ---STNIETELRPSNNLNLLSFEDS--TTGGVQQ--------------------------KQIRE 335

  Fly   389 HFPLVMKSHTSDDVLLLCPTCHQLSNISDLRVRSKLAVQCEAPFKQEDGSVKYHDDPQLKRVQSA 453
            |..|:   |..|:.  ..||...|:......|   |..:.|   ::|||.....:|.:||.    
Human   336 HEVLI---HVEDET--WDPTLDHLAKHDGEDV---LGNKVE---RKEDGFEDGVEDNKLKE---- 385

  Fly   454 GKALLHHGAKIPAAKKAEMEKTLLDYYSDQTDITE---DLLRQAASVEY 499
                             .||:..|    ...||||   .:|.|.:..||
Human   386 -----------------NMERACL----MSLDITEHELQILEQQSQEEY 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Exd2NP_650075.1 WRN_exo 62..226 CDD:176653 52/154 (34%)
WRNNP_000544.2 Interaction with WRNIP1. /evidence=ECO:0000250|UniProtKB:O09053 2..277 66/224 (29%)
KBM 1. /evidence=ECO:0000305|PubMed:27063109 11..23
RNaseD_like 61..229 CDD:176650 52/166 (31%)
PTZ00341 <156..480 CDD:173534 77/361 (21%)
2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K 424..477
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 498..529
recQ_fam 538..1010 CDD:129701
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 668..671
Interaction with DNA. /evidence=ECO:0000269|PubMed:20159463 987..993
HRDC 1156..1229 CDD:128635
HTH_40 1258..1352 CDD:464189
KBM 2. /evidence=ECO:0000305|PubMed:27063109 1403..1412
XLM. /evidence=ECO:0000305|PubMed:27063109 1419..1432
Blue background indicates that the domain is not in the aligned region.

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