Protein Alignment Exd2 and EXD2

DIOPT Version :10

• Sequence 1: NP_650075.1
• Gene: Exd2 / 41374
• FlyBaseID: FBgn0037901
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001180289.1
• Gene: EXD2 / 55218
• HGNCID: 20217
• Length: 621
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 239/627 - (38%)
• Similarity: 354/627 - (56%)
• Gaps: 89/627 - (14%)

  Fly     1 MTRESAVATKRNWAILAAGVG--LVYVLVRHRHRLLC------PLRRVWSFGSLVPQRRIEVINS 57
            |:|::.||.... .:|...||  :::..::.|.|...      |.::|.....|.|....::.:|
Human     1 MSRQNLVALTVT-TLLGVAVGGFVLWKGIQRRRRSKTSPVTQQPQQKVLGSRELPPPEDDQLHSS 64

  Fly    58 VQDPTTQW-----------VLNE---------LKNHCQTFKVLGFDCEWITVGGSRRPVALLQLS 102
            .  |.:.|           |..|         |::..:.|.|||.||||:.:.|...|::|||::
Human    65 A--PRSSWKERILKAKVVTVSQEAEWDQIEPLLRSELEDFPVLGIDCEWVNLEGKASPLSLLQMA 127

  Fly   103 SHRGLCALFRL----CHMKQIPQDLRELLEDDSVIKVGVAPQEDAMKLSHDYGVGVASTLDLRFL 163
            |..|||.|.||    |..|.:|:.|.::|.|.:::||||...|||.||..|||:.|...||||:|
Human   128 SPSGLCVLVRLPKLICGGKTLPRTLLDILADGTILKVGVGCSEDASKLLQDYGLVVRGCLDLRYL 192

  Fly   164 CVMAGHK--PEGLG--KLSKTHLNYTLDKHWRLACSNWEAKTLEPKQLDYAANDALMAVAIYQKL 224
            .:...:.  ..||.  .|::|.||:.|||...|.||||:|:||...|:.|||.||.::||::..|
Human   193 AMRQRNNLLCNGLSLKSLAETVLNFPLDKSLLLRCSNWDAETLTEDQVIYAARDAQISVALFLHL 257

  Fly   225 C---------RDLQPKHFWQRRQLDDNSMHNKFEPFLDVDF-TKGFT-LNPSGSG-VTRSKGSTQ 277
            .         .:....|...|:.|:      |.:..:|:.| :||.: |....:| .|.|:...:
Human   258 LGYPFSRNSPGEKNDDHSSWRKVLE------KCQGVVDIPFRSKGMSRLGEEVNGEATESQQKPR 316

  Fly   278 SKSNK---WVP-----------KKQP----YRQIATRTKDFYDNCLLQAPDGELLCTIDRRKASW 324
            :|.:|   .||           |::|    |   :.|....||||.|.||||:.|||.|||||.|
Human   317 NKKSKMDGMVPGNHQGRDPRKHKRKPLGVGY---SARKSPLYDNCFLHAPDGQPLCTCDRRKAQW 378

  Fly   325 YLNQNLGTHISEEPFTVRLNFEPAGRAVGDVGRFYQTIKKNQCVVCGDRDAYIRKNVVPREYRKH 389
            ||::.:|..:|||||.|:|.||||||.... |.:|..:|:|.|||||.||:||||||:|.|||||
Human   379 YLDKGIGELVSEEPFVVKLRFEPAGRPESP-GDYYLMVKENLCVVCGKRDSYIRKNVIPHEYRKH 442

  Fly   390 FPLVMKSHTSDDVLLLCPTCHQLSNISDLRVRSKLAVQCEAPFKQEDGSVKYHDDPQLKRVQSAG 454
            ||:.||.|.|.||||||.:||.:||..|..::.:||.:.:||...|:| ::..:||:.::|:|..
Human   443 FPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEG-LRLLEDPERRQVRSGA 506

  Fly   455 KALLHHGAKIPAAKKAEMEKTLLDYYSDQTD-ITEDLLRQAASVEYRVENSDYCQHGERVVQQYR 518
            :||| :...:|..:|.|:.:.|.::|:  || :||::|::|||:|.|:.|.:|..||.:|||.:.
Human   507 RALL-NAESLPTQRKEELLQALREFYN--TDVVTEEMLQEAASLETRISNENYVPHGLKVVQCHS 568

  Fly   519 DHFGG---LVELERLWRQHFLHTMQPRFLPELWNVNHNADRL 557
            .  ||   |::||..||||||.:|||:.||:.|:|:||..:|
Human   569 Q--GGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exd2	NP_650075.1	WRN_exo	62..226	CDD:176653	74/200 (37%)
EXD2	NP_001180289.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..68		6/35 (17%)
		WRN_exo	82..258	CDD:176653	72/175 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	299..343		9/43 (21%)